JKE-1674 |
| Catalog No.GC47477 |
A GPX4 inhibitor and active metabolite of ML-210
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2421119-60-8
Sample solution is provided at 25 µL, 10mM.
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JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4) and an active metabolite of the GPX4 inhibitor ML-210 .1 JKE-1674 reduces viability of LOX-IMVI cancer cells (EC50 = 0.03 µM) and in a panel of additional cancer cell lines, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 .
1.Eaton, J.K., Furst, L., Ruberto, R.A., et al.Selective covalent targeting of GPX4 using masked nitrile-oxide electrophilesNat. Chem. Biol.16(5)497-506(2020)
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)
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