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Home >> Signaling Pathways >> Immunology/Inflammation >> NO Synthase

NO Synthase

Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO synthases catalyze the oxidation of L-arginine to NO and L-citrulline. Mammals contain three NOS isoforms: neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS). NO produced from these different NOS isoforms is involved in a wide range of physiologic functions in the nervous, immune, and cardiovascular systems. Unregulated NO production can lead to pathologic conditions such as stroke, inflammation, and hypertension. Therefore, the control of NOS activity by isoform selective NOS inhibitors has great potential for therapeutic treatments of NO-related diseases.

Targets for  NO Synthase

Products for  NO Synthase

  1. Cat.No. Product Name Information
  2. GC40262 α-Humulene

    αCaryophyllene, (±)-αHumulene

     α-Humulene is a sesquiterpene that has been found in C. α-Humulene Chemical Structure
  3. GC70953 α7 nAchR-JAK2-STAT3 agonist 1 α7 nAchR-JAK2-STAT3 agonist 1 is a potent α7 nAchR-JAK2-STAT3 agonist, with an IC50 value of 0.32 μM for nitric oxide (NO). α7 nAchR-JAK2-STAT3 agonist 1 Chemical Structure
  4. GC80412 (E)-Sinapoyl glucose

    Raphanusol B

     (E)-Sinapoyl glucose is an inflammatory pathway inhibitor. (E)-Sinapoyl glucose Chemical Structure
  5. GC71831 (Rac)-Anemonin (Rac)-Anemonin ((Rac)-Pulsatilla camphor) is the diastereoisomer of Anemonin . (Rac)-Anemonin Chemical Structure
  6. GC69799 (Rac)-ZLc-002

    (Rac)-ZLc-002 is an inhibitor that interacts with the binding protein between nNOS and nitric oxide synthase 1 (NOS1AP). It inhibits inflammatory pain and chemotherapy-induced neuropathic pain, and synergistically reduces tumor cell viability with Paclitaxel.

     (Rac)-ZLc-002 Chemical Structure
  7. GC13563 1400W dihydrochloride 1400W dihydrochloride is a potent inhibitor of inducible nitric oxide synthase (iNOS) with a Kd value≤7nM. 1400W dihydrochloride Chemical Structure
  8. GC64739 2-Aminoquinoline 2-Aminoquinoline (2-Quinolinamine) is a promising compound as bioavailable nNOS inhibitor but suffers from low human nNOS inhibition, low selectivity versus human eNOS, and significant binding to other CNS targets. 2-Aminoquinoline Chemical Structure
  9. GC16664 2-Iminobiotin

    Guanidinobiotin

     iNOS and nNOS inhibitor 2-Iminobiotin Chemical Structure
  10. GC39326 2-Iminobiotin hydrobromide 2-Iminobiotin hydrobromide (Guanidinobiotin hydrobromide) is a biotin (vitamin H or B7) analog. 2-Iminobiotin hydrobromide Chemical Structure
  11. GC34451 3',4'-Dihydroxyflavonol 3',4'-Dihydroxyflavonol (DiOHF) is an effective antioxidant, which reduces superoxide and improves nitric oxide (NO) function in diabetic rat mesenteric arteries. 3',4'-Dihydroxyflavonol Chemical Structure
  12. GC68081 3-Amino-1,2,4-triazine 3-Amino-1,2,4-triazine Chemical Structure
  13. GC38208 3-Bromo-7-nitroindazole A potent inhibitor of nNOS 3-Bromo-7-nitroindazole Chemical Structure
  14. GC45673 7,8-Dihydroneopterin

    D-erythro-7,8-Dihydroneopterin

     An antioxidant 7,8-Dihydroneopterin Chemical Structure
  15. GC78899 7-Oxomogroside V 7-Oxomogroside V is a cucurbitane-type glycoside isolated from the fruits of Siraitia grosvenorii. 7-Oxomogroside V Chemical Structure
  16. GC16831 Agmatine sulfate

    NIH 11035

     α2-adrenergic receptor ligand Agmatine sulfate Chemical Structure
  17. GC68649 Amaroswerin

    Amaroswerin is a biologically active thiosesquiterpene glycoside extracted from the plant Huperzia serrata. Amaroswerin has anti-inflammatory, antidiabetic, antiviral, anticholinergic and immunomodulatory activities. In RAW264.7 cells, Amaroswerin inhibits NO release with an IC50 value of 5.42 μg/mL.

     Amaroswerin Chemical Structure
  18. GC65226 Aminopicoline Aminopicoline (Ascensil) is a potent and nonselective inhibitor of NO synthase (NOS) isoenzymes (iNOS, nNOS, eNOS). Aminopicoline Chemical Structure
  19. GN10685 Anemarsaponin B Anemarsaponin B Chemical Structure
  20. GC38735 AR-C102222 hydrochloride AR-C102222 hydrochloride is a potent, competitive, orally active and highly selective inducible nitric oxide synthase (iNOS) inhibitor, with an IC50 of 37 nM. AR-C102222 hydrochloride Chemical Structure
  21. GC35411 Asperuloside An iridoid glycoside with diverse biological activities Asperuloside Chemical Structure
  22. GC32457 Asymmetric dimethylarginine

    ADMA, Asymmetric dimethylarginine

     An endogenous NOS inhibitor Asymmetric dimethylarginine Chemical Structure
  23. GC32486 AVE-3085 AVE-3085 is a potent endothelial nitric oxide synthase enhancer, used for cardiovascular disease treatment. AVE-3085 Chemical Structure
  24. GC79486 Bacoside A (mixture) Bacoside A (mixture) is a mixture composed of Bacoside A3, Bacopaside II, Bacopaside X and Bacopasaponin C. Bacoside A (mixture) Chemical Structure
  25. GC62860 Bakkenolide B Bakkenolide B is a sesquiterpene lactone compound isolated from the leaves of Petaites japonicas, possessing anti-allergic and anti-inflammatory effects. Bakkenolide B Chemical Structure
  26. GC34046 Bendazol Bendazol is a hypotensive drug which can also enhance NO synthase activity in renal glomeruli and collecting tubules. Bendazol Chemical Structure
  27. GC62878 Bryonolic acid Bryonolic acid is an active triterpenoid compound with immunomodulatory, anti-inflammatory, antioxidant and anticancer activities. Bryonolic acid Chemical Structure
  28. GC70485 Celiprolol-d9 hydrochloride Celiprolol-d9 (hydrochloride) is the deuterium labeled Celiprolol hydrochloride. Celiprolol-d9 hydrochloride Chemical Structure
  29. GN10342 Chondroitin sulfate (from bovine)

    Chondroitin polysulfate sulfate (from bovine)

     Chondroitin sulfate (from bovine) is a natural polysaccharide extracted from bovine cartilage. Chondroitin sulfate (from bovine) Chemical Structure
  30. GC38900 Ciwujianoside C3 Ciwujianoside?C3, an orally active and brain penetrated compound, is isolated the leaves of Acanthopanax?henryi Harms. Ciwujianoside C3 Chemical Structure
  31. GC50347 CORM 2 CORM 2 is a carbon monoxide-releasing molecule that can liberate a controlled amount of CO in biological systems and has been developed as a carbon monoxide donor. CORM 2 Chemical Structure
  32. GC38224 Crocin II Crocin II Chemical Structure
  33. GC18864 Curvularin

    (-)-Curvularin, (S)-Curvularin, NSC 166071

     Curvularin is a natural fungal macrolactone that has cytotoxic activity against select cancer cell lines. Curvularin Chemical Structure
  34. GC38431 Dehydroevodiamine Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, has an antiarrhythmic effect in guinea-pig ventricular myocytes. Dehydroevodiamine Chemical Structure
  35. GC80409 Deltoin Deltoin is a Coumarine derivative. Deltoin Chemical Structure
  36. GC18259 DETA NONOate

    Diethylenetriamine NONOate, NOC18

    A NO donor

     DETA NONOate Chemical Structure
  37. GC60152 Epibetulinic acid Epibetulinic acid exhibits potent inhibitory effects on NO and prostaglandin E2 (PGE2) production in mouse macrophages (RAW 264.7) stimulated with bacterial endotoxin with IC50s of 0.7 and 0.6 μM, respectively. Epibetulinic acid Chemical Structure
  38. GC61669 Ethyl 3,4-dihydroxybenzoate Ethyl 3,4-dihydroxybenzoate (Ethyl protocatechuate), an antioxidant, is a prolyl-hydroxylase inhibitor found in the testa of peanut seeds. Ethyl 3,4-dihydroxybenzoate Chemical Structure
  39. GC38678 Ethyl Caffeate Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl Caffeate Chemical Structure
  40. GC31364 Fucoxanthin (all-trans-Fucoxanthin) Fucoxanthin (all-trans-Fucoxanthin) is a naturally occurring carotenoid widely distributed in edible brown seaweed and diatoms. Fucoxanthin (all-trans-Fucoxanthin) Chemical Structure
  41. GN10220 Ginsenoside Rb3

    Ginsenoside IV

     Ginsenoside Rb3 Chemical Structure
  42. GC31673 GW274150 GW274150 is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50=2.19 μM; Kd=40 nM) and rat iNOS (ED50=1.15 μM). GW274150 Chemical Structure
  43. GC39388 GW274150 phosphate GW274150 phosphate is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50=2.19 μM; Kd=40 nM) and rat iNOS (ED50=1.15 μM). GW274150 phosphate Chemical Structure
  44. GA10738 H-Arg-OH H-Arg-OH Chemical Structure
  45. GA11127 H-Arg-OH.HCl

    L-(+)-Arginine, NSC 7914, NSC 203450

     H-Arg-OH.HCl Chemical Structure
  46. GC69280 iNOs-IN-1

    iNOs-IN-1 (YPW) is an effective inhibitor of inducible nitric oxide synthase (iNOS). It significantly inhibits the expression of IL-6 and iNOS in mouse macrophages, as well as NO production induced by LPS, with a dose-dependent effect. It has anti-inflammatory properties.

     iNOs-IN-1 Chemical Structure
  47. GN10205 Irisflorentin Irisflorentin Chemical Structure
  48. GC72008 Isomaculosidine Isomaculosidine is an alkaloid that can be isolated from D. dasycarpus. Isomaculosidine Chemical Structure
  49. GC41273 Isoquercetin

    NSC 115918, Quercetin 3-β-D-glucoside, Quercetin 3-O-glucoside

     Isoquercetin is a flavonoid with diverse biological activities, including antioxidant, antiproliferative, and anti-inflammatory properties. Isoquercetin Chemical Structure
  50. GC45488 Isosorbide Dinitrate

    NSC 80038

       Isosorbide Dinitrate Chemical Structure
  51. GC71948 Kadsulignan H Kadsulignan H (compound 13) is a lignan with inhibitory activity on NO production. Kadsulignan H Chemical Structure
  52. GC31391 Kuwanon A Kuwanon A is a flavone derivative isolated from the root barks of the mulberry tree (Morus alba L. Kuwanon A Chemical Structure
  53. GC68379 L-Arginine-13C6,15N4 hydrochloride

    (S)-(+)-Arginine-13C6,15N4 hydrochloride

     L-Arginine-13C6,15N4 hydrochloride Chemical Structure
  54. GC65194 L-Arginine-15N2 hydrochloride

    (S)-(+)-Arginine-15N2 hydrochloride

     L-Arginine-15N2 hydrochloride Chemical Structure
  55. GC63918 L-Arginine-15N4 hydrochloride

    (S)-(+)-Arginine-15N4 hydrochloride

     L-Arginine-15N4 hydrochloride Chemical Structure
  56. GC16200 L-Biopterin

    L-erythro-Biopterin,NSC 339699

     L-Biopterin (L-Biopterin), a pterin derivative, is a NO synthase cofactor. L-Biopterin Chemical Structure
  57. GC16656 L-Canavanine sulfate iNOS inhibitor L-Canavanine sulfate Chemical Structure
  58. GA11233 L-NAME hydrochloride

    LNGNitroarginine methyl ester, N(G)-NitroL-arginine methyl ester

     L-NAME hydrochloride is a non-selective, competitive nitric oxide synthase (NOS) inhibitor (IC50=70μM). L-NAME hydrochloride inhibits nNOS (Ki=15nM), eNOS (Ki=39nM) and iNOS (Ki=4.4μM) activities. L-NAME hydrochloride Chemical Structure
  59. GC36471 L-NIL L-NIL is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for miNOS. L-NIL Chemical Structure
  60. GC12867 L-NIO dihydrochloride inhibitor of nitric oxide (NO) synthase L-NIO dihydrochloride Chemical Structure
  61. GC16926 L-NMMA acetate

    LNGmonomethyl Arginine acetate

     L-NMMA acetate is a potent inhibitor of Nitric-Oxide Synthase (NOS), with an IC50 of 2μM. L-NMMA acetate Chemical Structure
  62. GC80411 Leonuriside A Leonuriside A is a phenolic compound that can be isolated from Leonurus japonicus. Leonuriside A Chemical Structure
  63. GC13051 Lipoamide

    α-Lipoamide, DL-α-Lipoic Acid amide, NSC 90787, (±)-Thioctic Acid amide

     Lipoamide is a neutral amide derivative with coenzyme activity. Lipoamide Chemical Structure
  64. GC61015 Luteolin 5-O-glucoside Luteolin 5-O-glucoside, a major flavonoidfrom Cirsium maackii, possesses anti-inflammatory activity. Luteolin 5-O-glucoside Chemical Structure
  65. GC30051 Methylene Blue (Basic Blue 9) Methylene blue (Basic Blue 9) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene Blue (Basic Blue 9) Chemical Structure
  66. GC39603 Methylene blue trihydrate Methylene blue trihydrate (C. Methylene blue trihydrate Chemical Structure
  67. GC78900 Momilactone A Momilactone A is a naturally derived diterpene lactone with multiple biological activities including anticancer, antibacterial and antioxidant properties. Momilactone A Chemical Structure
  68. GC73494 MSU-42011 MSU-42011 is an orally active retinoid X receptor (RXR) agonist. MSU-42011 Chemical Structure
  69. GC26295 N-cis-Feruloyl tyramine Cis-N-Feruloyltyramine is a phenolic compound extracted from the fruits of Lycium barbarum with antioxidant activity. N-cis-Feruloyl tyramine Chemical Structure
  70. GC38972 Naringenin chalcone

    2',4,4',6'-Tetrahydroxychalcone

     Naringenin chalcone functions as an anti-allergic compound that can be taken orally and has shown effectiveness in reducing human placental CYP19A1 activity with an IC50 value of 2.6μmol/L. Naringenin chalcone Chemical Structure
  71. GC60267 Neocryptotanshinone Neocryptotanshinone, a fatty diterpenoids from Salvia Miltiorrhiza, inhibits lipopolysaccharide-induced inflammation by suppression of NF-κB and iNOS signaling pathways. Neocryptotanshinone Chemical Structure
  72. GC79408 NOS-IN-4 NOS-IN-4 (Compound 3) is a neuronal nitric oxide synthase ( nNOS ) inhibitor with an IC50 of 4.00 μM that inhibits nNOS activity. NOS-IN-4 Chemical Structure
  73. GC50011 Nw-Propyl-L-arginine hydrochloride

    N-omega-Propyl-L-arginine hydrochloride

     Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) hydrochloride is a potent, competitive, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS), with a Ki of 57 nM. Nw-Propyl-L-arginine hydrochloride Chemical Structure
  74. GC74298 Oxidized low density lipoprotein (Human)

    Human ox-LDL

    Oxidized low density lipoprotein (Human) (Human ox-LDL) is involved in atherogenesis.

     Oxidized low density lipoprotein (Human) Chemical Structure
  75. GC36914 Piceatannol 3'-O-glucoside Piceatannol 3'-O-glucoside, an active component of Rhubarb, activates endothelial nitric oxide (NO) synthase through inhibition of arginase activity with IC50s of 11.22 ?M and 11.06 ?M against arginase I and arginase II, respectively. Piceatannol 3'-O-glucoside Chemical Structure
  76. GN10395 Prim-O-glucosylcimifugin

    1''-O-Glucosylcimifugin, PGCN

     Prim-O-glucosylcimifugin Chemical Structure
  77. GC79409 Pulchinenoside K Pulchinenoside K (Compound 4) is a triterpenoid saponin. Pulchinenoside K Chemical Structure
  78. GC61235 Regaloside B Regaloside B is a phenylpropanoid isolated from Lilium longiflorum. Regaloside B Chemical Structure
  79. GC33468 Rehmannioside A Rehmannioside A is an inhibitor of cytochrome P450 enzymes (CYP3A4, 2C9, and 2D6), with IC50 values of 10.08, 12.62, and 16.43μM, respectively. Rehmannioside A Chemical Structure
  80. GC61238 Rehmapicrogenin

    Rehmapicrogenin, isolated from the root of Rehmannia glutinosa, exhibits potent anti-inflammatory effect by inhibiting iNOS, COX-2 and IL-6.

     Rehmapicrogenin Chemical Structure
  81. GC31243 S-MTC

    S-MTC is a selective type I nitric oxide synthase (NOS) inhibitor.

     S-MTC Chemical Structure
  82. GC71950 Schiarisanrin A Schiarisanrin A (Kadsulignan J) is a lignan with inhibitory activity on NO production. Schiarisanrin A Chemical Structure
  83. GC64474 Secologanic acid Secologanic acid is a naturally occurring monoterpenoid aglycone compound belonging to the class of iridoid terpenes. Secologanic acid Chemical Structure
  84. GC30323 Syzalterin Syzalterin is an inhibitor of NO production with an IC50 of 1.87 μg/mL. Syzalterin Chemical Structure
  85. GC30774 Tat-NR2B9c

    Tat-NR2Bct; NA-1

     Tat-NR2B9c is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7nM and 670nM for PSD-95d2 and PSD-95d1, respectively. Tat-NR2B9c Chemical Structure
  86. GC34828 Tat-NR2B9c TFA

    Tat-NR2Bct TFA; NA-1 TFA

     Tat-NR2B9c TFA (Tat-NR2Bct TFA) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c TFA Chemical Structure
  87. GC60354 Tat-NR2Baa Tat-NR2BAA is the control peptide of Tat-NR2B9c, inactive. Tat-NR2Baa Chemical Structure
  88. GC31672 Tetrahydrobiopterin (Sapropterin) Tetrahydrobiopterin (Sapropterin) ((Rac)-Sapropterin) is a cofactor of the aromatic amino acid hydroxylases enzymes and also acts as an essential cofactor for all nitric oxide synthase (NOS) isoforms. Tetrahydrobiopterin (Sapropterin) Chemical Structure
  89. GC34255 TP508 TP508 is a 23-amino acid nonproteolytic thrombin peptide that represents a portion of the receptor-binding domain of thrombin molecule. TP508 Chemical Structure
  90. GC39515 TP508 TFA TP508 TFA is a 23-amino acid nonproteolytic thrombin peptide that represents a portion of the receptor-binding domain of thrombin molecule. TP508 TFA Chemical Structure
  91. GC26091 ZLc002 ZLc-002 is a selective inhibitor of nNOS-Capon coupling. ZLc-002 suppresses inflammatory nociception and chemotherapy-induced neuropathic pain. ZLc002 Chemical Structure

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