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Lipoxin B4 (Synonyms: LXB4)

Catalog No.GC18681

Lipoxin B4 (LXB4) is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15(S)-HpETE by human leukocytes.

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Lipoxin B4 Chemical Structure

Cas No.: 98049-69-5

Size Price Stock Qty
25μg
$385.00
In stock
50μg
$731.00
In stock
100μg
$1,383.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Lipoxin B4 (LXB4) is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15(S)-HpETE by human leukocytes. At a concentration of 100 nM, LXB4 inhibits polymorphonuclear leukocyte (PMN) migration stimulated by leukotriene B4 and inhibits LTB4-induced adhesion of PMNs with an IC50 value of 0.3 nM.

References:
[1]. Serhan, C.N., Hamberg, M., Samuelsson, B., et al. On the stereochemistry and biosynthesis of lipoxin B Proc. Nat. Acad. Sci. USA 83(7), 1983-1987 (1986).
[2]. Serhan, C.N., Hamberg, M., and Samuelsson, B. Lipoxins: Novel series of biologically active compounds formed from arachidonic acid in human leukocytes Proc. Natl. Acad. Sci. U.S.A. 81(17), 5335-5339 (1984).
[3]. Papayianni, A., Serhan, C.N., and Brady, H.R. Lipoxin A4 and B4 inhibit leukotriene-stimulated interactions of human neutrophils and endothelial cells Journal of Immunology 156, 2264-2272 (1996).

Chemical Properties

Cas No. 98049-69-5 SDF
Synonyms LXB4
Chemical Name 5S,14R,15S-trihydroxy-6E,8Z,10E,12E-eicosatetraenoic acid
Canonical SMILES O[C@@H](CCCC(O)=O)/C=C/C=C\C=C\C=C\[C@@H](O)[C@@H](O)CCCCC
Formula C20H32O5 M.Wt 352.5
Solubility DMF: >50 mg/ml,Ethanol: >50 mg/ml,PBS pH 7.2: >1 mg/ml (from 13(S)-HODE) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.8369 mL 14.1844 mL 28.3688 mL
5 mM 0.5674 mL 2.8369 mL 5.6738 mL
10 mM 0.2837 mL 1.4184 mL 2.8369 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 7 reference(s) in Google Scholar.)

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