Lometrexol |
| Catalog No.GC18404 |
Glycinamide ribonucleotide formyltransferase (GART) is a folate-dependent enzyme required for de novo purine synthesis.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 106400-81-1
Sample solution is provided at 25 µL, 10mM.
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Glycinamide ribonucleotide formyltransferase (GART) is a folate-dependent enzyme required for de novo purine synthesis. Lometrexol is a folate analog antimetabolite with antineoplastic activity. At nanomolar conentrations, it inhibits GART preventing de novo purine synthesis, inhibiting DNA synthesis, arresting cells in the S phase of the cell cycle, and inhibiting tumor cell proliferation.
Review for Lometrexol
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
Review for Lometrexol
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