IF 21
PMID: 42336735 ↗Fluvastatin
Catalog No.: GC13535Purity:>98.00%Synonyms: NSC 758896
Fluvastatin, a lipophilic 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, suppresses proliferation and induces apoptosis in various cancer cells.
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Cas No.: 93957-54-1
10mM (in 1mL DMSO)In Stock
$17.00
1
5mgIn Stock
$15.00
1
10mgIn Stock
$20.00
1
25mgIn Stock
$37.00
1
50mgIn Stock
$53.00
1
100mgIn Stock
$84.00
1
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 10mM (in 1mL DMSO) | $17.00 | In Stock | 1 | |
| 5mg | $15.00 | In Stock | 1 | |
| 10mg | $20.00 | In Stock | 1 | |
| 25mg | $37.00 | In Stock | 1 | |
| 50mg | $53.00 | In Stock | 1 | |
| 100mg | $84.00 | In Stock | 1 |
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Citations
1 publicationsPublications from researchers using this productDescription
Fluvastatin, a lipophilic 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, suppresses proliferation and induces apoptosis in various cancer cells[1-2]. Fluvastatin, which structurally mimics HMG-CoA to competitively block the enzyme’s active site, lowers total and low-density lipoprotein (LDL) cholesterol while exerting anti-atherogenic, antithrombotic, and antioxidant effects and improving vascular function[2-3].
In vitro, after 72h of treatment with the increasing concentrations of Fluvastatin (5, 10, and 20μM), human endometrial cancer (EC) cells exhibited a concentration-dependent decline in viability and proliferation, markedly reduced migration and invasion, and elevated apoptosis accompanied by progressive up-regulation of p53 and cleaved caspase-3[4]. A 24h incubation with 2.5μM Fluvastatin reproducibly gave over 50% inhibition of thrombin-induced von Willebrand factor (vWF) secretion, was more effective than shorter incubation times, did not disrupt the human umbilical-vein endothelial cells (HUVEC) culture monolayer, and did not change vWF antigen levels measured in cell lysates[5].
In vivo, after four daily intraperitoneal injections of 10mg/kg Fluvastatin in female C57BL/6J mice, total peritoneal cell counts remained unchanged, yet the proportion and absolute number of mast cells recovered from peritoneal lavage were markedly reduced[6]. The rats treated by gavage with 10mg/kg Fluvastatin showed a reduced number of polymorphonuclear neutrophils (PMN) compared to the control rats at 4h postinjection[7].
References:
[1] Zhang W, Wu J, Zhou L, et al. Fluvastatin, a lipophilic statin, induces apoptosis in human hepatocellular carcinoma cells through mitochondria-operated pathway. Indian J Exp Biol. 2010;48(12):1167-1174.
[2] Langtry HD, Markham A. Fluvastatin: a review of its use in lipid disorders. Drugs. 1999;57(4):583-606.
[3] Bonds M, Bordoni B. Fluvastatin. In: StatPearls. StatPearls Publishing; 2023.
[4] Cai Y, Zhao F. Fluvastatin suppresses the proliferation, invasion, and migration and promotes the apoptosis of endometrial cancer cells by upregulating Sirtuin 6 (SIRT6). Bioengineered. 2021;12(2):12509-12520.
[5] Fish RJ, Yang H, Viglino C, et al. Fluvastatin inhibits regulated secretion of endothelial cell von Willebrand factor in response to diverse secretagogues. Biochem J. 2007;405(3):597-604.
[6] Paez PA, Kolawole M, Taruselli MT, et al. Fluvastatin Induces Apoptosis in Primary and Transformed Mast Cells. J Pharmacol Exp Ther. 2020;374(1):104-112.
[7] Fischetti F, Carretta R, Borotto G, et al. Fluvastatin treatment inhibits leucocyte adhesion and extravasation in models of complement-mediated acute inflammation. Clin Exp Immunol. 2004;135(2):186-193.
Protocol
| Cell experiment [1]: | |
Cell lines | Human endometrial cancer (EC) cell lines (RL95-2 and KLE) |
Preparation Method | Cells were maintained at 37°C with 5% CO2 and cultivated in DMEM containing 10% FBS. 48h later, Fluvastatin with different concentrations (5, 10, 20μM) was employed to incubate cells for 72h for the following experiments. |
Reaction Conditions | 5, 10, 20μM; 72h |
Applications | Fluvastatin inhibited the viability and proliferation of KLE and RL95-2 endometrial cancer cells in a concentration-dependent manner, while markedly suppressing their migratory and invasive capacities. Fluvastatin dose-dependently triggered apoptosis in KLE and RL95-2 cells, accompanied by progressive increases in p53 and cleaved caspase-3 levels. |
| Animal experiment [2]: | |
Animal models | Female C57BL/6J mice |
Preparation Method | Female C57BL/6J mice received 10mg/kg Fluvastatin or vehicle (DMSO diluted in PBS to match Fluvastatin solvent) daily by intraperitoneal injection for 4 days. Mice were sacrificed, and peritoneal lavage was harvested and analyzed for mast cells by staining for CD45+ cells and gating on FcεRI+/c-Kit+ cells. Cross sections of the small intestine were also analyzed by histology, using staining with pinacyanol erythosinate to identify mast cells. |
Dosage form | 10mg/kg; intraperitoneal injection |
Applications | Fluvastatin did not reduce total peritoneal cells but greatly reduced the proportion and total number of mast cells found in peritoneal lavage. |
References: | |
Product Documents
Purity:>98.00%Appearance:A solid
Chemical Properties
CAS No.
93957-54-1
Synonyms
NSC 758896
Chemical Name
(E,3R,5S)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoic acid
SMILES
CC(C)N1C2=CC=CC=C2C(=C1C=CC(CC(CC(=O)O)O)O)C3=CC=C(C=C3)F
Molecular Formula
C24H26FNO4
Molecular Weight
411.47
Solubility
≥ 20.57 mg/mL in DMSO, ≥ 42.2 mg/mL in EtOH with gentle warming, ≥ 32.53 mg/mL in Water with gentle warming
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility
g/mol
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