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LY 379268

Catalog No.GC14861

Group II mGlu receptor agonist, highly selective

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LY 379268 Chemical Structure

Cas No.: 191471-52-0

Size Price Stock Qty
1mg
$65.00
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5mg
$270.00
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10mg
$444.00
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Sample solution is provided at 25 µL, 10mM.

Product has been cited by 1 publications

Product Documents

Quality Control & SDS

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Background

LY 379268 is a highly selective group II mGlu receptor agonist with EC50 value of 2.69 and 4.48 nM for hmGlu2 and hmGlu3, respectively [1].
mGluRs is a type of glutamate receptor that is being considered as targets for the therapeutic intervention in neurodegenerative disorders. Activation of Group II mGluRs can protect cultured neurones against excitotoxic damage by inhibiting glutamate release [1].
In the CA1 hippocampal cells, LY379268 reduced the ischemia-induced hyperactivity and provided protection after 5-min bilateral carotid artery occlusion (BCAO). Furthermore, before 5-min BCAO, 24- or 48-h pretreatment with LY379268 educed the damage to CA1 hippocampal neurons in a gerbil model [2].
In the gerbil bilateral occlusion of the carotid artery, LY379268 prevented the loss of CA1 hippocampal neurones. Also, LY379268 decreased the BCAO-induced increase in TUNEL positive cells. In the rat model, LY379268 didn’t affect the size of the infarct following middle cerebral artery occlusion (MCAO) [1].
References:
[1]. Bond A, Ragumoorthy N, Monn JA, et al. LY379268, a potent and selective Group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal, cerebral ischaemia. Neurosci Lett, 1999, 273(3): 191-194.
[2]. Bond A, Jones NM, Hicks CA, et al. Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: investigations into possible mechanism of action in vivo. J Pharmacol Exp Ther, 2000, 294(3): 800-809.

Chemical Properties

Cas No. 191471-52-0 SDF
Chemical Name (1R,4R,5S,6R)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid
Canonical SMILES OC([C@@H]1[C@@H]2[C@H]1OC[C@]2(C(O)=O)N)=O
Formula C7H9NO5 M.Wt 187.15
Solubility 25 mM in Water Storage Store at 4°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 5.3433 mL 26.7165 mL 53.4331 mL
5 mM 1.0687 mL 5.3433 mL 10.6866 mL
10 mM 0.5343 mL 2.6717 mL 5.3433 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 3 reference(s) in Google Scholar.)

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