Home>>Signaling Pathways>> Neuroscience>> GluR>>LY 379268

LY 379268

Catalog No.: GC14861

Group II mGlu receptor agonist, highly selective

Products are for research use only. Not for human use. We do not sell to patients.

LY 379268 Chemical Structure

Cas No.:191471-52-0

Size Price Stock Qty
In stock
In stock
In stock

Customer Reviews

Based on customer reviews.

Tel: (626) 353-8530 Email: sales@glpbio.com

Sample solution is provided at 25 µL, 10mM.

Product has been cited by 1 publications

Product Documents

Quality Control & SDS

View current batch:


LY 379268 is a highly selective group II mGlu receptor agonist with EC50 value of 2.69 and 4.48 nM for hmGlu2 and hmGlu3, respectively [1].
mGluRs is a type of glutamate receptor that is being considered as targets for the therapeutic intervention in neurodegenerative disorders. Activation of Group II mGluRs can protect cultured neurones against excitotoxic damage by inhibiting glutamate release [1].
In the CA1 hippocampal cells, LY379268 reduced the ischemia-induced hyperactivity and provided protection after 5-min bilateral carotid artery occlusion (BCAO). Furthermore, before 5-min BCAO, 24- or 48-h pretreatment with LY379268 educed the damage to CA1 hippocampal neurons in a gerbil model [2].
In the gerbil bilateral occlusion of the carotid artery, LY379268 prevented the loss of CA1 hippocampal neurones. Also, LY379268 decreased the BCAO-induced increase in TUNEL positive cells. In the rat model, LY379268 didn’t affect the size of the infarct following middle cerebral artery occlusion (MCAO) [1].
[1]. Bond A, Ragumoorthy N, Monn JA, et al. LY379268, a potent and selective Group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal, cerebral ischaemia. Neurosci Lett, 1999, 273(3): 191-194.
[2]. Bond A, Jones NM, Hicks CA, et al. Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: investigations into possible mechanism of action in vivo. J Pharmacol Exp Ther, 2000, 294(3): 800-809.

Chemical Properties

Cas No. 191471-52-0 SDF
Chemical Name (1R,4R,5S,6R)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid
Canonical SMILES OC([C@@H]1[C@@H]2[C@H]1OC[C@]2(C(O)=O)N)=O
Formula C7H9NO5 M.Wt 187.15
Solubility 25 mM in Water Storage Store at 4°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % saline

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

  • Molarity Calculator

  • Dilution Calculator

  • Molecular Weight Calculator

**When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / CoA (available online).



Review for LY 379268

Average Rating: 5 ★★★★★ (Based on Reviews and 3 reference(s) in Google Scholar.)

5 Star
4 Star
3 Star
2 Star
1 Star
Review for LY 379268

GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.

Required fields are marked with *

You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.