Nicotinamide riboside-d4 (triflate) |
Catalog No.GC52214 |
An internal standard for the quantification of nicotinamide riboside
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
Nicotinamide riboside-d4 is intended for use as an internal standard for the quantification of nicotinamide riboside by GC- or LC-MS. Nicotinamide riboside is a riboside form of nicotinamide that is found in trace amounts in yeast-containing and milk-derived products.1 It is a precursor of NAD+ and a source of vitamin B3 (niacin). Nicotinamide riboside increases intracellular and mitochondrial NAD+ content in C2C12, Hepa1.6, and HEK293 cells when used at concentrations ranging from 1-1,000 μM.2 It also decreases acetylation of FOXO1 and SOD2, which are substrates of sirtuin 1 (SIRT1) and SIRT3, respectively, but not the SIRT2 substrate tubulin, indicating nicotinamide riboside selectively enhances SIRT1 and SIRT3 deacetylase activity. Nicotinamide riboside (400 mg/kg per day) increases NAD+ levels in liver and skeletal muscle and prevents body weight gain in mice fed a high-fat diet. It also increases NAD+ in the cerebral cortex and reduces cognitive deterioration in a transgenic mouse model of Alzheimer's disease.3
1.Chi, Y., and Sauve, A.A.Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotectionCurr. Opin. Clin. Nutr. Metab. Care15(6)657-661(2013) 2.CantÓ, C., Houtkooper, R.H., Pirinen, E., et al.The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesityCell Metab.15(6)838-847(2012) 3.Gong, B., Pan, Y., Vempati, P., et al.Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse modelsNeurobiol. Aging34(6)1581-1588(2013)
Average Rating: 5
(Based on Reviews and 30 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *