NVP-2 |
| Catalog No.GC34056 |
NVP-2 is a potent and selective ATP-competitive cyclin dependent kinase 9 (CDK9) probe, inhibits CDK9/CycT activity with an IC50 of 0.514 nM. NVP-2 displays inhibitory effcts on CDK1/CycB, CDK2/CycA and CDK16/CycY kinases with IC50 values of 0.584 ?M, 0.706 ?M, and 0.605 ?M, respectively. NVP-2 induces cell apoptosis.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1263373-43-8
Sample solution is provided at 25 µL, 10mM.
Product has been cited by 1 publications
Product Documents
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
NVP-2 is a CDK9 inhibitor with an IC50 of 0.5 nM.
[1]. Wang J, et al. SnapShot: Kinase Inhibitors I. Mol Cell. 2015 May 21;58(4):708.e1.
| Cas No. | 1263373-43-8 | SDF | |
| Canonical SMILES | ClC1=CN=C(N[C@H]2CC[C@H](N[C@H](C)COC)CC2)C=C1C3=CC=CC(NCC4(C#N)CCOCC4)=N3 | ||
| Formula | C27H37ClN6O2 | M.Wt | 513.07 |
| Solubility | DMSO : ≥ 100 mg/mL (194.91 mM) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
Complete Stock Solution Preparation Table
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.9491 mL | 9.7453 mL | 19.4905 mL |
| 5 mM | 0.3898 mL | 1.9491 mL | 3.8981 mL |
| 10 mM | 0.1949 mL | 0.9745 mL | 1.9491 mL |
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
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