ONO 6818 (Synonyms: ONO-6818; ONO-PO-736) |
| Catalog No.GC50225 |
ONO 6818 (ONO-6818) is a potent and orally active neutrophil elastase inhibitor with a Ki of 12.2 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 208848-19-5
Sample solution is provided at 25 µL, 10mM.
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High affinity and selective human neutrophil elastase 1 (HNE1) inhibitor (Ki = 12 nM). Exhibits >100-fold less activity at other related proteases including trypsin, pancreatic elastase, collagenase and murine macrophage elastase. Inhibits HNE-induced lung hemorrhaging and suppresses leukocyte levels in an in vivo model of COPD. Orally active.
Hirota et al (2004) Effects of the neutrophil elastase inhibitor (ONO-6818) on acetic acid induced colitis in Syrian hamsters. J.Vet.Med.Sci. 66 1223 PMID:15528853 |Aoshiba et al (2001) Serine proteases increase oxidative stress in lung cells. Am.J.Physiol.Lung Cell Mol.Physiol. 281 556 PMID:11504681 |Stevens et al (2011) AZD9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase. J.Pharmacol.Exp.Ther. 339 313 PMID:21791628
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