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Home >> Signaling Pathways >> Apoptosis >> Pyroptosis

Pyroptosis

Products for  Pyroptosis

  1. Cat.No. Product Name Information
  2. GA20494 Ac-Asp-Glu-Val-Asp-pNA

    Ac-Asp-Glu-Val-Asp-pNA

     The cleavage of the chromogenic caspase-3 substrate Ac-DEVD-pNA can be monitored at 405 nm. Ac-Asp-Glu-Val-Asp-pNA Chemical Structure
  3. GC48470 Ac-DEVD-CHO (trifluoroacetate salt)

    N-Ac-Asp-Glu-Val-Asp-CHO

     A dual caspase3/caspase7 inhibitor Ac-DEVD-CHO (trifluoroacetate salt) Chemical Structure
  4. GC65107 Ac-FEID-CMK TFA Ac-FEID-CMK TFA is a potent zebrafish-specific GSDMEb-derived peptide inhibitor. Ac-FEID-CMK TFA Chemical Structure
  5. GC60558 Ac-FLTD-CMK Ac-FLTD-CMK, a gasdermin D (GSDMD)-derived inhibitor, is a specific inflammatory caspases inhibitor. Ac-FLTD-CMK Chemical Structure
  6. GC49704 Ac-FLTD-CMK (trifluoroacetate salt)

    Ac-Phe-Leu-Thr-Asp-CMK

     An inhibitor of caspase-1, -4, -5, and -11 Ac-FLTD-CMK (trifluoroacetate salt) Chemical Structure
  7. GC42708 Ac-LEHD-AFC (trifluoroacetate salt)

    N-Acetyl-Leu-Glu-His-Asp-7-amino-4-Trifluoromethylcoumarin, Caspase-9 substrate (Fluorogenic)

     Ac-LEHD-AFC is a fluorogenic substrate that can be cleaved by caspase-4, -5, and -9. Ac-LEHD-AFC (trifluoroacetate salt) Chemical Structure
  8. GC42709 Ac-LEVD-CHO (trifluoroacetate salt)

    Ac-Leu-Glu-Val-Asp-CHO, Caspase-4 Inhibitor I

    Ac-LEVD-CHO is a caspase-4 inhibitor.

     Ac-LEVD-CHO (trifluoroacetate salt) Chemical Structure
  9. GC40124 Ac-WEAD-AMC (trifluoroacetate salt)

    Ac-Trp-Glu-Ala-Asp-AMC

     Ac-WEAD-AMC is a fluorogenic substrate for caspase-1 and caspase-4. Ac-WEAD-AMC (trifluoroacetate salt) Chemical Structure
  10. GC42719 Ac-WEAD-pNA (trifluoroacetate salt)

    Ac-Trp-Glu-Ala-Asp-pNA, Ac-Trp-Glu-Ala-Asp-p-nitroanilide, Caspase-1 and Caspase-4 Chromogenic Substrate

     Ac-WEAD-pNA is a colorimetric substrate for caspase-1 and caspase-4. Ac-WEAD-pNA (trifluoroacetate salt) Chemical Structure
  11. GC46796 Ac-WEHD-AFC (trifluoroacetate salt)

    N-Acetyl-Trp-Glu-His-Asp-7-amino-4-Trifluoromethylcoumarin, Caspase1 Substrate (Fluorogenic), Caspase5 Substrate (Fluorogenic)

     A neuropeptide with diverse biological activities Ac-WEHD-AFC (trifluoroacetate salt) Chemical Structure
  12. GC18021 Ac-YVAD-CHO

    Caspase-1 Inhibitor I, L 709049, N-Ac-Tyr-Val-Ala-Asp-CHO

     Selective inhibitor of interleukin-1β converting enzyme (ICE; Caspase-1) Ac-YVAD-CHO Chemical Structure
  13. GC42721 Ac-YVAD-CMK

    N-Ac-Tyr-Val-Ala-Asp-CMK

     Ac-YVAD-CMK is a selective irreversible inhibitor of caspase-1 (Ki=0.8nM), which can prevent the proinflammatory cytokine IL-1β activation. Ac-YVAD-CMK can reduce the inflammatory response and induce a long-lasting neuroprotective effect. Ac-YVAD-CMK Chemical Structure
  14. GC40149 Boc-AEVD-CHO (trifluoroacetate salt)

    Boc-Ala-Glu-Val-Asp-CHO

     Boc-AEVD-CHO is an inhibitor of caspase-8 (Ki = 1.6 nM) that also inhibits caspase-1, -3, -6, and -9 (Kis = 10,000, 375, 438, 425, and 320 nM, respectively). Boc-AEVD-CHO (trifluoroacetate salt) Chemical Structure
  15. GC18421 Dabcyl-YVADAPV-EDANS

    Dabcyl-ICE-EDANS

     Dabcyl-YVADAPV-EDANS is a fluorogenic substrate for caspase-1. Dabcyl-YVADAPV-EDANS Chemical Structure
  16. GC91060 Ferritin PROTAC DeFer-2

    A PROTAC that drives ferritin degradation

     Ferritin PROTAC DeFer-2 Chemical Structure
  17. GC43668 FITC-C6-YVADAP-K(Dnp) (trifluoroacetate salt)

    FITC-C6-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-OH

     FITC-C6-YVADAP-K(Dnp) is a caspase-1 fluorogenic substrate. FITC-C6-YVADAP-K(Dnp) (trifluoroacetate salt) Chemical Structure
  18. GC74070 INF 195 INF 195 is an NLRP3 inhibitor. INF 195 Chemical Structure
  19. GC65393 LDC7559 LDC7559 is a gasdermin D (GSDMD) inhibitor via blocking neutrophil extracellular trap (NET) in the late stages . LDC7559 Chemical Structure
  20. GC40120 Mca-LEVDGW-K(Dnp)-NH2 (trifluoroacetate salt)

    Mca-Leu-Glu-Val-Asp-Gly-Trp-Lys(Dnp)-NH2

     Mca-LEVDGW-K(Dnp)-NH2 is a fluorogenic substrate for caspase-4. Mca-LEVDGW-K(Dnp)-NH2 (trifluoroacetate salt) Chemical Structure
  21. GC47607 Mca-YVADAP-K(Dnp)-OH (trifluoroacetate salt)

    Caspase-1 Fluorogenic Substrate V, Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(DNP)-OH, Mca-YVADAP-Lys(Dnp)-OH, (7-Methoxycoumarin-4-yl)acetyl-YVADAPK(2,4-dinitrophenyl)-OH

     A neuropeptide with diverse biological activities Mca-YVADAP-K(Dnp)-OH (trifluoroacetate salt) Chemical Structure
  22. GC49681 Necrosulfonamide-d4

    NSA-d4

     Necrosulfonamide-d4 is the deuterium labeled Necrosulfonamide. Necrosulfonamide is a necroptosis inhibitor acting by selectively targeting the mixed lineage kinase domain-like protein (MLKL). Necrosulfonamide prevents MLKL-RIP1-RIP3 necrosome complex from interacting with its downstream effectors. MLKL is a critical substrate of RIP3 during the induction of necrosis. Necrosulfonamide-d4 Chemical Structure
  23. GC49024 Palmitic Acid MaxSpec® Standard

    C16:0, Cetylic Acid, NSC 5030

     A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications Palmitic Acid MaxSpec® Standard Chemical Structure
  24. GC49023 Palmitic Acid-d9 MaxSpec® Standard

    C16:0-d9, Cetylic Acid-d9

     A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications Palmitic Acid-d9 MaxSpec® Standard Chemical Structure
  25. GC72191 Pep19-2.5 Pep19-2.5 is an synthetic and antitoxin peptide, blocks the intracellular endotoxin signaling cascade. Pep19-2.5 Chemical Structure
  26. GC44967 Suc-YVAD-AMC (acetate)

    Suc-Tyr-Val-Ala-Asp-AMC, Suc-Tyr-Val-Ala-Asp-7-amino-4-methylcoumarin, Suc-YVAD-NH-Mec

     Suc-YVAD-AMC is a fluorogenic substrate for caspase-1. Suc-YVAD-AMC (acetate) Chemical Structure
  27. GC45175 YVAD-CHO (trifluoroacetate salt)

    H-Tyr-Val-Ala-Asp-CHO

     YVAD-CHO is an inhibitor of caspase-1/interleukin-1β converting enzyme (ICE) and a non-acetylated form of Ac-YVAD-CHO. YVAD-CHO (trifluoroacetate salt) Chemical Structure
  28. GC45178 Z-DEVD-CMK (trifluoroacetate salt)

    Z-Asp-Glu-Val-Asp-CMK

    Z-DEVD-CMK is a protease inhibitor.

     Z-DEVD-CMK (trifluoroacetate salt) Chemical Structure
  29. GC40151 Z-VAD-AMC (acetate)

    Z-Val-Ala-Asp-AMC, Z-Val-Ala-Asp-7-amino-4-methylcoumarin

     Z-VAD-AMC is a fluorogenic substrate for caspase-1. Z-VAD-AMC (acetate) Chemical Structure
  30. GC40153 Z-YVAD-AFC (trifluoroacetate salt)

    Z-Tyr-Val-Ala-Asp-AFC, Z-Tyr-Val-Ala-Asp-7-amino-4-trifluoromethylcoumarin, Z-YVAD-7-amino-4-trifluoromethylcoumarin

     Z-YVAD-AFC is a fluorogenic substrate for caspase-1. Z-YVAD-AFC (trifluoroacetate salt) Chemical Structure
  31. GC45193 Z-YVAD-CMK (trifluoroacetate salt)

    Benxyloxycarbonyl-Tyr-Val-Ala-Asp-Chloromethylketone, Caspase-1 Inhibitor IV

    Z-YVAD-CMK is an inhibitor of caspase-1 and caspase-3.

     Z-YVAD-CMK (trifluoroacetate salt) Chemical Structure
  32. GC40119 Z-YVADLD-FMK (trifluoroacetate salt)

    Z-Tyr-Val-Ala-Asp-Leu-Asp-FMK

     Z-YVADLD-FMK is a peptide that contains the amino acid sequence YVAD, which is the cleavage site for caspase-1 and -4. Z-YVADLD-FMK (trifluoroacetate salt) Chemical Structure

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