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Home >> Signaling Pathways >> Membrane Transporter/Ion Channel >> CFTR

CFTR

CFTR (cystic fibrosis transmembrane conductance regulator) is an ABC transporter-class ion channel that conducts chloride[3] and thiocyanate[4] ions across epithelial cell membranes.

Products for  CFTR

  1. Cat.No. Product Name Information
  2. GC31665 (R)-BPO-27 (R)-BPO-27, the R enantiomer of BPO-27, is a potent, orally active and ATP-competitive CFTR?inhibitor with an?IC50 of 4 nM. (R)-BPO-27 Chemical Structure
  3. GC69812 (R)-Elexacaftor

    (R)-Elexacaftor is the enantiomer of Elexacaftor (Compound 1) and comes from Compound 37 in patent WO2018107100A1. It is a corrector of cystic fibrosis transmembrane conductance regulator (CFTR), with an EC50 value of 0.29 uM for CFTR dF508.

     (R)-Elexacaftor Chemical Structure
  4. GC67767 (R)-Olacaftor (R)-Olacaftor Chemical Structure
  5. GC62513 (R)-Posenacaftor sodium (R)-Posenacaftor (R)-PTI-801) sodium is the R enantiomer of Posenacaftor. (R)-Posenacaftor sodium Chemical Structure
  6. GC30537 BPO-27 racemate BPO-27 racemate is a potent CFTR inhibitor with an IC50 of 8 nM. BPO-27 racemate Chemical Structure
  7. GC63976 Cavosonstat Cavosonstat (N91115) is an orally active S-nitrosoglutathione reductase (GSNOR) inhibitor. Cavosonstat Chemical Structure
  8. GC35667 CFTR corrector 1 CFTR corrector 1 (VX-445, Compound 1) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). CFTR corrector 1 Chemical Structure
  9. GC34532 CFTR corrector 2 CFTR corrector 2 is a cystic fibrosis transmembrane conductance corrector (CFTR), extracted from patent US20140274933. CFTR corrector 2 Chemical Structure
  10. GC67939 CFTR corrector 4 CFTR corrector 4 Chemical Structure
  11. GC62510 CFTR corrector 6 CFTR corrector 6 is a potent potentiator of Cystic Fibrosis Transmembrane conductance Regulator (CFTR). CFTR corrector 6 Chemical Structure
  12. GC68282 CFTR corrector 8 CFTR corrector 8 Chemical Structure
  13. GC65029 CFTR corrector 9 CFTR corrector 9 (compound 42) is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator. CFTR corrector 9 Chemical Structure
  14. GC14421 CFTRinh-172 CFTR inhibitor, highly potent and selective CFTRinh-172 Chemical Structure
  15. GC67925 Crinecerfont hydrochloride Crinecerfont hydrochloride Chemical Structure
  16. GC64121 Dirocaftor Dirocaftor Chemical Structure
  17. GC68397 Galicaftor Galicaftor Chemical Structure
  18. GC19169 GLPG1837 GLPG1837 is a potent and reversible CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively. GLPG1837 Chemical Structure
  19. GC36149 GLPG2451 GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC50 of 11.1 nM. GLPG2451 Chemical Structure
  20. GC17804 GlyH-101 CFTR Inhibitor II GlyH-101 Chemical Structure
  21. GC63353 Icenticaftor Icenticaftor (QBW251) is an orally active CFTR channel potentiator, with EC50s of 79 nM and 497 nM for F508del and G551D CFTR, respectively. Icenticaftor Chemical Structure
  22. GC11229 IOWH-032 CFTR inhibitor IOWH-032 Chemical Structure
  23. GC10296 Ivacaftor (VX-770) Ivacaftor (VX-770) (VX-770) is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC50s of 100 nM and 25 nM, respectively. Ivacaftor (VX-770) Chemical Structure
  24. GC12489 Ivacaftor benzenesulfonate A CFTR potentiator Ivacaftor benzenesulfonate Chemical Structure
  25. GC13316 Ivacaftor hydrate A CFTR potentiator Ivacaftor hydrate Chemical Structure
  26. GC64678 K41498 TFA K41498 TFA is a potent and highly selective CRF2?receptor antagonist with Ki?values of 0.66 nM, 0.62 nM and 425 nM for human CRF2α, CRF2β?and CRF1 receptors respectively. K41498 TFA Chemical Structure
  27. GC14914 KM 11060 Corrects F508del-CFTR trafficking KM 11060 Chemical Structure
  28. GC63479 Navocaftor Navocaftor (GLPG 3067), as a cystic fibrosis transmembrane regulator (CFTR), is a protein modulator (US 20200377491 Al, example 1). Navocaftor Chemical Structure
  29. GC68015 NJH-2-057 NJH-2-057 Chemical Structure
  30. GC64358 Olacaftor Olacaftor (VX-440) is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator extracted from patent US9782408. Olacaftor Chemical Structure
  31. GC10288 PG 01 CFTR mutants potentiator PG 01 Chemical Structure
  32. GC62522 Posenacaftor sodium Posenacaftor (PTI-801) sodium is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of?CFTR?protein. Posenacaftor sodium Chemical Structure
  33. GC17616 PPQ-102 potent CFTR inhibitor PPQ-102 Chemical Structure
  34. GC12346 PTC124(Ataluren) PTC124(Ataluren) (PTC124) is an orally available CFTR-G542X nonsense allele inhibitor. PTC124(Ataluren) Chemical Structure
  35. GC34745 PTI-428 PTI-428 (PTI-428) is a specific cystic fibrosis transmembrane conductance regulator (CFTR) amplifier. PTI-428 Chemical Structure
  36. GC67789 SRI-37240 SRI-37240 Chemical Structure
  37. GC69942 SRI-41315

    SRI-41315 induces long pauses at termination codons, inhibits premature termination codons (PTCs) associated with permanent and primary human bronchial epithelial cell cystic fibrosis, restores the expression and function of CFTR (cystic fibrosis transmembrane conductance regulator). SRI-41315 inhibits PTCs by reducing the abundance of the termination factor eRF1. SRI-41315 also enhances aminoglycoside-mediated readthrough, resulting in synergistic increases in CFTR activity.

     SRI-41315 Chemical Structure
  38. GC14920 VX-661 VX-661 (VX-661) is a second F508del CFTR corrector and help CFTR protein reach the cell surface. VX-661 Chemical Structure
  39. GC15455 VX-809 VX-809 (VX-809; VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein. VX-809 Chemical Structure

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