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Home >> Signaling Pathways >> Tyrosine Kinase >> IRAK

IRAK

Interleukin receptor-associated kinase (IRAK) is a family of serine/threonine-protein kinase that plays a vital role in innate immune immunity. It is involved in the TLR and IL-1R signaling pathways which associated with the autoimmune and inflammatory diseases.

Products for  IRAK

  1. Cat.No. Product Name Information
  2. GC46013 AS-2444697 (hydrochloride) AS-2444697 (hydrochloride) is an orally active IRAK-4 inhibitor with an IC50 of 21 nM. AS-2444697 (hydrochloride) Chemical Structure
  3. GC33054 AZ1495 An oral active inhibitor of IRAK4 AZ1495 Chemical Structure
  4. GC32748 CA-4948 CA-4948 is a selective, potent and orally active interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor, extracted from patent WO2015104688 (example 1). CA-4948 Chemical Structure
  5. GC67879 Edecesertib Edecesertib Chemical Structure
  6. GN10156 Ginsenoside Rb1 Ginsenoside Rb1 Chemical Structure
  7. GC68458 HS-243 HS-243 Chemical Structure
  8. GC65941 HS-276 HS-276 is an orally active, potent and highly selective TAK1 inhibitor, with a Ki of 2.5 nM. HS-276 shows significant inhibition of TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1, with IC50 values of 8.25, 29, 33, 63, 125, 264, 270, 810, 1280, and 5585 nM, respectively. HS-276 can be used for rheumatoid arthritis (RA) research. HS-276 Chemical Structure
  9. GC62429 HS271 HS271 is a highly potent, orally active and selective IRAK4 inhibitor, with an IC50 of 7.2 μM. HS271 Chemical Structure
  10. GC17158 IRAK inhibitor 1 An IRAK4 inhibitor IRAK inhibitor 1 Chemical Structure
  11. GC12651 IRAK inhibitor 2 IRAK inhibitor 2 Chemical Structure
  12. GC11103 IRAK inhibitor 3 IRAK inhibitor 3 Chemical Structure
  13. GC16264 IRAK inhibitor 4 IRAK inhibitor 4 Chemical Structure
  14. GC36328 IRAK inhibitor 4 trans IRAK inhibitor 4 (trans) is the trans form of IRAK inhibitor 4. IRAK inhibitor 4 trans Chemical Structure
  15. GC17371 IRAK inhibitor 6 An IRAK4 inhibitor IRAK inhibitor 6 Chemical Structure
  16. GC15999 IRAK-1-4 Inhibitor I A benzimidazole IRAK-1-4 Inhibitor I Chemical Structure
  17. GC62583 IRAK-4 protein kinase inhibitor 2 IRAK-4 protein kinase inhibitor 2 (compound 1) is a potent inhibitor of interleukin-1 (IL-1) receptor-associated kinase-4 (IRAK-4), with an IC50 of 4 μM. IRAK-4 protein kinase inhibitor 2 Chemical Structure
  18. GC31688 IRAK4-IN-1 IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM. IRAK4-IN-1 Chemical Structure
  19. GC38799 IRAK4-IN-4 IRAK4-IN-4 is an interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor extracted from patent CN107163044A, Compound15, has an IC50 of 2.8 nM. IRAK4-IN-4 Chemical Structure
  20. GC61944 IRAK4-IN-6 IRAK4-IN-6 is an orally efficacious and selective IRAK4 inhibitor with an IC50 of 4 nM, and targetes MyD88 L265P mutant diffuse large B cell lymphoma. IRAK4-IN-6 Chemical Structure
  21. GC63925 JH-X-119-01 JH-X-119-01 is a potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 Chemical Structure
  22. GC19287 PF06650833 PF06650833 (PF-06650833) is a potent, selective and orally active inhibitor of interleukin-1 receptor associated kinase 4 (IRAK4) with IC50s of 0.2 and 2.4 nM in the cell and PBMC assay, respectively. PF06650833 Chemical Structure
  23. GC62197 PROTAC IRAK4 degrader-1 PROTAC IRAK4 degrader-1 is a Cereblon-based PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1 Compound I-210, makes 20-50%, and >50% IRAK4 degradation at 0.01, 0.1, and 1 μM in OCI-LY-10 cells, respectively. PROTAC IRAK4 degrader-1 Chemical Structure
  24. GC63263 Zabedosertib Zabedosertib (BAY 1834845) is a IRAK4 inhibitor with immunomodulatory potential. Zabedosertib Chemical Structure

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