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Home >> Signaling Pathways >> Tyrosine Kinase >> IRAK

IRAK

Interleukin receptor-associated kinase (IRAK) is a family of serine/threonine-protein kinase that plays a vital role in innate immune immunity. It is involved in the TLR and IL-1R signaling pathways which associated with the autoimmune and inflammatory diseases.

Products for  IRAK

  1. Cat.No. Product Name Information
  2. GC46013 AS-2444697 (hydrochloride) AS-2444697 (hydrochloride) is an orally active IRAK-4 inhibitor with an IC50 of 21 nM. AS-2444697 (hydrochloride) Chemical Structure
  3. GC33054 AZ1495 An oral active inhibitor of IRAK4 AZ1495 Chemical Structure
  4. GC32748 CA-4948 CA-4948 is a selective, potent and orally active interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor, extracted from patent WO2015104688 (example 1). CA-4948 Chemical Structure
  5. GC67879 Edecesertib

    GS-5718

     Edecesertib Chemical Structure
  6. GC20007 Ginsenoside CK

    Ginsenoside Compound K, Ginsenoside IH901; Compound K

    Ginsenoside C-K, a bacterial metabolite of G-Rb1, exhibits anti-inflammatory effects by reducing iNOS and COX-2. Ginsenoside C-K exhibits an inhibition against the activity of CYP2C9 and CYP2A6 in human liver microsomes with IC50s of 32.0±3.6 μM and 63.6±4.2 μM, respectively.

     Ginsenoside CK Chemical Structure
  7. GN10156 Ginsenoside Rb1

    Gypenoside III, NSC 310103

     Ginsenoside Rb1 Chemical Structure
  8. GC71226 GLPG2534 GLPG2534 is an orally active and selective IRAK4 inhibitor, with IC50 values of 6.4 nM and 3.5 nM for human and mouse IRAK4. GLPG2534 Chemical Structure
  9. GC68458 HS-243 HS-243 Chemical Structure
  10. GC65941 HS-276 HS-276 is an orally active, potent and highly selective TAK1 inhibitor, with a Ki of 2.5 nM. HS-276 shows significant inhibition of TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1, with IC50 values of 8.25, 29, 33, 63, 125, 264, 270, 810, 1280, and 5585 nM, respectively. HS-276 can be used for rheumatoid arthritis (RA) research. HS-276 Chemical Structure
  11. GC62429 HS271 HS271 is a highly potent, orally active and selective IRAK4 inhibitor, with an IC50 of 7.2 μM. HS271 Chemical Structure
  12. GC17158 IRAK inhibitor 1

    IRAK4-IN-1

     An IRAK4 inhibitor IRAK inhibitor 1 Chemical Structure
  13. GC12651 IRAK inhibitor 2 IRAK inhibitor 2 Chemical Structure
  14. GC11103 IRAK inhibitor 3 IRAK inhibitor 3 Chemical Structure
  15. GC16264 IRAK inhibitor 4 IRAK inhibitor 4 Chemical Structure
  16. GC36328 IRAK inhibitor 4 trans IRAK inhibitor 4 (trans) is the trans form of IRAK inhibitor 4. IRAK inhibitor 4 trans Chemical Structure
  17. GC17371 IRAK inhibitor 6 An IRAK4 inhibitor IRAK inhibitor 6 Chemical Structure
  18. GC15999 IRAK-1-4 Inhibitor I A benzimidazole IRAK-1-4 Inhibitor I Chemical Structure
  19. GC62583 IRAK-4 protein kinase inhibitor 2 IRAK-4 protein kinase inhibitor 2 (compound 1) is a potent inhibitor of interleukin-1 (IL-1) receptor-associated kinase-4 (IRAK-4), with an IC50 of 4 μM. IRAK-4 protein kinase inhibitor 2 Chemical Structure
  20. GC31688 IRAK4-IN-1 IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM. IRAK4-IN-1 Chemical Structure
  21. GC71135 IRAK4-IN-20 IRAK4-IN-20 (Compound BAY-1834845) is an orally active IRAK4 inhibitor with an IC50 of 3.55 nM. IRAK4-IN-20 Chemical Structure
  22. GC69288 IRAK4-IN-21

    IRAK4-IN-21 (Compound 17) is an orally effective and selective potent IRAK4 inhibitor with IC50 values of 5 and 56 nM for IRAK4 and TAK1, respectively. It can effectively inhibit the production of IL-23 (IC50=0.17 μM) and may be used in research on autoimmune diseases such as psoriasis vulgaris and psoriatic arthritis.

     IRAK4-IN-21 Chemical Structure
  23. GC69289 IRAK4-IN-22

    IRAK4-IN-22 (compound 18) is an orally effective and selective potent IRAK4 inhibitor with IC50 values of 3 and 17 nM for IRAK4 and TAK1, respectively. IRAK4-IN-21 can effectively inhibit the production of IL-23 (IC50=0.10 μM), which can be used in research on autoimmune diseases such as psoriasis vulgaris and psoriatic arthritis.

     IRAK4-IN-22 Chemical Structure
  24. GC38799 IRAK4-IN-4 IRAK4-IN-4 is an interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor extracted from patent CN107163044A, Compound15, has an IC50 of 2.8 nM. IRAK4-IN-4 Chemical Structure
  25. GC61944 IRAK4-IN-6 IRAK4-IN-6 is an orally efficacious and selective IRAK4 inhibitor with an IC50 of 4 nM, and targetes MyD88 L265P mutant diffuse large B cell lymphoma. IRAK4-IN-6 Chemical Structure
  26. GC63925 JH-X-119-01 JH-X-119-01 is a potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 Chemical Structure
  27. GC73873 KME-2780 KME-2780 is a potent and selective dual IRAK1 and IRAK4 inhibitor and can be used for research of dysregulation of innate immune signaling and hematologic malignancies. KME-2780 Chemical Structure
  28. GC73159 KTX-582 KTX-582 is a potent IRAK4 degrader with DC50 values of 4 nM and 5 nM for IRAK4 and Ikaros, respectively. KTX-582 Chemical Structure
  29. GC73161 KTX-951 KTX-951 is a PROTAC targeting IRAK4 degradation (DC50=18 nM). KTX-951 Chemical Structure
  30. GC73414 Larotinib Larotinib is a potent broad-spectrum and orally active tyrosine kinase inhibitor (TKI) with EGFR as the main target with an IC50 of 0.6 nM. Larotinib Chemical Structure
  31. GC19287 PF06650833

    PF-06650833

     PF06650833 (PF-06650833) is a potent, selective and orally active inhibitor of interleukin-1 receptor associated kinase 4 (IRAK4) with IC50s of 0.2 and 2.4 nM in the cell and PBMC assay, respectively. PF06650833 Chemical Structure
  32. GC62197 PROTAC IRAK4 degrader-1 PROTAC IRAK4 degrader-1 is a Cereblon-based PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1 Compound I-210, makes 20-50%, and >50% IRAK4 degradation at 0.01, 0.1, and 1 μM in OCI-LY-10 cells, respectively. PROTAC IRAK4 degrader-1 Chemical Structure
  33. GC63263 Zabedosertib

    BAY 1834845

     Zabedosertib (BAY 1834845) is a IRAK4 inhibitor with immunomodulatory potential. Zabedosertib Chemical Structure

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