Rosnilimab (Mouse IgG2a) |
Catalog No.GC79372
One-Click Copy Product Info
|
Rosnilimab (Mouse IgG2a ) is a mouse-derived IgG2a antibody, Rosnilimab.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
_1-3.$$$39978408@51.jpg');)
_1-9.$$$38538795@65.jpg');)
_1-9.$$$39112701@51.jpg');)
_1-7.$$$37316672@70.jpg');)
_366-372.$$$36198801@70.jpg');)
.$$$38565142@65.jpg');)
_1867-1883.$$$33248023@67.jpg');)
_eads6055.$$$39977546@45.jpg');)
_eadm9805.$$$40080571@45.jpg');)
_eadj3020.$$$39666821@45.jpg');)
_1-20.$$$39757301@28.jpg');)
_1-24.$$$38898113@28.jpg');)
_273-287.$$$36806353@46.jpg');)
_1-16.$$$37156877@44.jpg');)
_1-19.$$$37460805@44.jpg');)
_1291-1307.$$$34518654@46.jpg');)
In Vivo, Rosnilimab (Mouse IgG2a) (10 mg/kg; i.p.; twice weekly; 4 weeks) demonstrates efficacy in a murine model of ulcerative colitis, reducing colonic inflammation, CD4+ T cell infiltration, and inflammatory cytokine gene expression while maintaining body weight[1]. Rosnilimab (Mouse IgG2a) (10 mg/kg; i.p.; twice weekly; 4 weeks) reduces pathogenic T cell and proinflammatory macrophage infiltration, and downregulates an inflammatory myeloid gene signature overlapping with human UC, in an adoptive transfer murine model of colitis[2].
References:
[1]. Dahl M, et al. Rosnilimab, a PD-1 Agonist Antibody in Clinical Development for Ulcerative Colitis, Reduces Pathogenic PD-1+ T Cells and Inflammatory Cytokine Secretion in Patient Blood and in a Mouse Model of Colitis [poster]. United European Gastroenterology Week (UEGW) 2024; 2024.
[2]. AnaptysBio. Rosnilimab, a Selective and Potent Depleter of Pathogenic T Cells, Downregulated an Inflammatory Myeloid Gene Signature in a Murine Model of Colitis that was Upregulated in Human UC Colon Tissue [poster]. United European Gastroenterology Week (UEGW) 2025; 2025.
[3]. Linggi B, et al. Phenotyping of Human UC Colonic Tissue Reveals Inflammatory Pathway Gene Expression in PD-1+ Conventional and Regulatory T Cells Which Overlap with Those Regulated by Rosnilimab in a Mouse Model of Colitis [poster]. United European Gastroenterology Week (UEGW) 2025 / Federation of Clinical Immunology Societies (FOCIS) 2025; 2025.
| Cas No. | SDF | ||
| Formula | M.Wt | 147.53 | |
| Solubility | Storage | Store at -20°C | |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 6.7783 mL | 33.8914 mL | 67.7828 mL |
| 5 mM | 1.3557 mL | 6.7783 mL | 13.5566 mL |
| 10 mM | 677.8 μL | 3.3891 mL | 6.7783 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A liquid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)