SAK 3 |
| Catalog No.GC50392 |
Potent CaV3.1 and 3.3 activator; orally bioavailable
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1256269-87-0
Sample solution is provided at 25 µL, 10mM.
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Potent CaV3.1 and CaV3.3 activator. Enhances CaV3.1 and CaV3.3, but not CaV3.2 activity at concentrations of 0.01 - 10 M in neuro2A cells in vitro. Elevates ACh levels in hippocampus. Rescues impaired memory-related behaviors, promotes adult neurogenesis and displays antidepressant-like effects in OBX mice. Orally bioavailable.
Yabuki et al (2017) Pharmacological properties of SAK3, a novel T-type voltage-gated Ca2+ channel enhancer. Neuropharmacology 117 1 PMID:28093211 |Xu et al (2018) T-type calcium channel enhancer SAK3 produces anti-depressant-like effects by promoting adult hippocampal neurogenesis in olfactory bulbectomized mice. J.Pharmacol.Sci. 137 333 PMID:30196018
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)
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