SIBA |
| Catalog No.GC33442 |
SIBA (5'-Isobutylthioadenosine) is a transmethylation inhibitor (SAH analogue), with potent anti-proliferative activity.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 35899-54-8
Sample solution is provided at 25 µL, 10mM.
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SIBA selectively inhibits spermine synthase, IC50=8 uM.IC50 value: 8 uMTarget: spermine synthaseSIBA is a powerful antiproliferative drug. SIBA has been reported to inhibit cell transformation induced by oncogenic RNA or DNA viruses, the growth of transformed mouse mammary cells, the mitogen-stimulated blastogenesis of lymphocytes and the capping of herpes virus mRNA 161. It has also been demonstrated that an antimalarial activity is exerted by SIBA against Plasmodium falciparum in cultures.
[1]. Carteni-Farina M, et al. Studies on the metabolism of 5'-isobutylthioadenosine (SIBA): phosphorolytic cleavage by methylthioadenosinephosphorylase. FEBS Lett. 1979 Aug 15;104(2):266-270. [2]. Lawrence F, et al. Effect of 5'-deoxy-5'-isobutylthioadenosine on putrescine uptake and polyamine biosynthesis by chick embryofibroblasts. Biochem J. 1982 Jun 15;204(3):853-859.
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