Stearoyl-L-carnitine (chloride) (Synonyms: C18 Carnitine) |
| Catalog No.GC44951 |
Stearoyl-L-carnitine is a naturally occurring long-chain acylcarnitine.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 32350-57-5
Sample solution is provided at 25 µL, 10mM.
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Stearoyl-L-carnitine is a naturally occurring long-chain acylcarnitine [1]. It inhibits sodium-dependent [3H]carnitine uptake in human proximal convoluted tubular (HPCT) cells by 52% when used at a concentration of 500 μM [2] It also inhibits lecithin:cholesterol acyltransferase activity in rat, but not human, plasma when used at a concentration of 500 μM/ml of plasma. [3] Plasma levels of stearoyl-L-carnitine are decreased in patients with chronic fatigue syndrome and increased in patients with end-stage renal disease.[1][4]
Reference:
[1]. Reuter, S.E., Evans, A.M., Faull, R.J., et al. Impact of haemodialysis on individual endogenous plasma acylcarnitine concentrations in end-stage renal disease. Ann. Clin. Biochem. 42(Pt 5), 387-393 (2005).
[2]. Huang, W., Shaikh, S.N., Ganapathy, M.E., et al. Carnitine transport and its inhibition by sulfonylureas in human kidney proximal tubular epithelial cells. Biochem. Pharmacol. 58(8), 1361-1370 (1999).
[3]. Bell, F.P. Carnitine esters: Novel inhibitors of plasma lecithin: Cholesterol acyltransferase in experimental animals but not in man (Homo sapiens). Int. J. Biochem. 15(2), 133-136 (1983).
[4]. Reuter, S.E., and Evans, A.M. Long-chain acylcarnitine deficiency in patients with chronic fatigue syndrome. Potential involvement of altered carnitine palmitoyltransferase-I activity. J. Intern. Med. 270(1), 76-84 (2011).
| Cas No. | 32350-57-5 | SDF | |
| Synonyms | C18 Carnitine | ||
| Chemical Name | 3-carboxy-N,N,N-trimethyl-2R-[(1-oxooctadecyl)oxy]-1-propanaminium, monochloride | ||
| Canonical SMILES | OC(C[C@H](C[N+](C)(C)C)OC(CCCCCCCCCCCCCCCCC)=O)=O.[Cl-] | ||
| Formula | C25H50NO4•Cl | M.Wt | 464.1 |
| Solubility | DMF: 20 mg/ml,DMSO: 14 mg/ml,Ethanol: 20 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.1547 mL | 10.7735 mL | 21.5471 mL |
| 5 mM | 0.4309 mL | 2.1547 mL | 4.3094 mL |
| 10 mM | 0.2155 mL | 1.0774 mL | 2.1547 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 33 reference(s) in Google Scholar.)
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