STF-62247 |
Catalog No.GC13918
One-Click Copy Product Info
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Autophagy inducer in renal cell
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 315702-99-9
Sample solution is provided at 25 µL, 10mM.
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IC50: STF-62247 inhibits tumor growth in wild-type VHL and VHL-deficient renal cell carcinoma (RCC) in a HIF-independent manner with IC50 of 16 μM and 0.625 μM, respectively.
Inactivation of the von Hippel-Lindau (VHL) tumor inhibitor gene results in a large number of renal cell carcinomas (RCCs) and is closely linked to a high degree of vascularization and poor prognosis. STF-62247 is reported to exhibit selectively cytotoxic toward VHL-deficient cells in vitro and in vivo. [1]
In vitro: In vitro study demonstrated that STF-62247 exhibited selectively cytotoxicity and tumor growth inhibitory activity towards wild-type VHL and VHL-deficient renal cell carcinoma (RCC) in a HIF-independent manner with IC50 of 16 μM and 0.625 μM, respectively. In addion, STF-62247 also resulted in cell apoptosis by inducing acidification and increasing autophagy in VHL-deficient cells. [1]
In vivo: Animal experiments for STF-62247 activity were performed according to institutional and national guidelines and approved by Stanford University's Administrative Panel on Laboratory Animal Care. Based on an in vivo mouse model, it was found that intraperitoneal injection of STF-62247 at a dose of 8 mg/kg significantly inhibited tumor growth of VHL-deficient SN12C tumor cells. [1]
Clinical trial: So far, no clinical trial has been conducted.
Reference:
[1]Turcotte S, Chan DA, Sutphin PD, Hay MP, Denny WA and Giaccia AJ. A molecule targeting vhl-deficient renal cell carcinoma that induces autophagy. Cancer Cell. 2008 Jul; 14: 90-102.
| Cas No. | 315702-99-9 | SDF | |
| Chemical Name | N-(3-methylphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine | ||
| Canonical SMILES | CC1=CC(=CC=C1)NC2=NC(=CS2)C3=CC=NC=C3 | ||
| Formula | C15H13N3S | M.Wt | 267.35 |
| Solubility | ≥ 9.35mg/mL in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.7404 mL | 18.7021 mL | 37.4042 mL |
| 5 mM | 748.1 μL | 3.7404 mL | 7.4808 mL |
| 10 mM | 374 μL | 1.8702 mL | 3.7404 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 7 reference(s) in Google Scholar.)