TH34 |
| Catalog No.GC19406 |
TH34 is a potent HDAC6/8/10 inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2196203-96-8
Sample solution is provided at 25 µL, 10mM.
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TH34 is a potent HDAC6/8/10 inhibitor. TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines. The combination of TH34 with plasma-achievable concentrations of retinoic acid, a drug applied in neuroblastoma therapy, synergistically inhibits colony growth (combination index (CI) < 0.1 for 10 µM of each). In summary, our study supports using selective HDAC inhibitors as targeted antineoplastic agents and underlines the therapeutic potential of selective HDAC6/8/10 inhibition in high-grade neuroblastoma.
Reference
1: Kolbinger FR, Koeneke E, Ridinger J, Heimburg T, Müller M, Bayer T, Sippl W, Jung M, Gunkel N, Miller AK, Westermann F, Witt O, Oehme I. The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines. Arch Toxicol. 2018 Aug;92(8):2649-2664. doi: 10.1007/s00204-018-2234-8. Epub 2018 Jun 9. PubMed PMID: 29947893; PubMed Central
PMCID: PMC6063332.
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
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