Verbascoside
Catalog No.: GC13232Purity:>99.50%Synonyms: Acteoside, NSC 603831
Verbascoside is an inhibitor of protein kinase C (PKC) isolated from Lantana camara, with an IC50 value of 25µM.
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Cas No.: 61276-17-3
10mM (in 1mL DMSO)In Stock
$37.00
1
1mgIn Stock
$12.00
1
5mgIn Stock
$27.00
1
10mgIn Stock
$44.00
1
25mgIn Stock
$88.00
1
50mgIn Stock
$152.00
1
100mgIn Stock
$240.00
1
200mgIn Stock
$352.00
1
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 10mM (in 1mL DMSO) | $37.00 | In Stock | 1 | |
| 1mg | $12.00 | In Stock | 1 | |
| 5mg | $27.00 | In Stock | 1 | |
| 10mg | $44.00 | In Stock | 1 | |
| 25mg | $88.00 | In Stock | 1 | |
| 50mg | $152.00 | In Stock | 1 | |
| 100mg | $240.00 | In Stock | 1 | |
| 200mg | $352.00 | In Stock | 1 |
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Citations
1 publicationsPublications from researchers using this productDescription
Verbascoside is an inhibitor of protein kinase C (PKC) isolated from Lantana camara, with an IC50 value of 25µM [1]. Verbascoside can down-regulate the expression of TRPV3 Ca2+-dependent temperature-sensitive channel and inhibit the TAK-1/JNK/AP-1 pathway by phosphorylating SHP-1, thereby exerting anti-inflammatory effects [2]. Verbascoside has been widely used to improve the histological morphology and clinical symptoms of animal colitis and to prevent skin damage caused by ultraviolet radiation[3].
In vitro, Verbascoside treatment for 24 hours significantly inhibited the cell viability of MCF-7 cells and MDA-MB 231 cells, with IC50 values of 0.1270µM and 0.1597µM, respectively[4]. 100µM of Verbascoside pretreatment for 3 hours protected C6 cells from LPS/IFN-γ-induced cell death and inhibited the increase in lipid peroxidation levels[5]. Treatment with 16µM Verbascoside for 5 days significantly enhanced the cell viability of human β cells under endoplasmic reticulum stress conditions, regulated redox homeostasis and improved mitochondrial function[6].
In vivo, Verbascoside treatment via oral administration at a dose of 10mg/kg/day for 42 days improved the memory and spatial cognition abilities of APP/PS1 mice, and reduced the Aβ deposition and tau protein accumulation in the brain tissues[7]. Oral administration of a 60mg/kg dose of Verbascoside daily for 12 weeks significantly inhibited the atherosclerotic pathological progression in ApoE−/− mice fed with a high-fat diet, and improved liver lipid metabolism[8].
References:
[1] Herbert J M, Maffrand J P, Taoubi K, et al. Verbascoside isolated from Lantana camara, an inhibitor of protein kinase C[J]. Journal of Natural Products, 1991, 54(6): 1595-1600.
[2] Saha R, Majie A, Baidya R, et al. Verbascoside: comprehensive review of a phenylethanoid macromolecule and its journey from nature to bench[J]. Inflammopharmacology, 2024, 32(5): 2729-2751.
[3] Alipieva K, Korkina L, Orhan I E, et al. Verbascoside—A review of its occurrence,(bio) synthesis and pharmacological significance[J]. Biotechnology advances, 2014, 32(6): 1065-1076.
[4] Şenol H, Tulay P, Ergören M C, et al. Cytotoxic Effects of Verbascoside on MCF-7 and MDA-MB-231[J]. Turkish Journal of Pharmaceutical Sciences, 2021, 18(5): 637.
[5] Esposito E, Dal Toso R, Pressi G, et al. Protective effect of verbascoside in activated C6 glioma cells: possible molecular mechanisms[J]. Naunyn-Schmiedeberg's archives of pharmacology, 2010, 381(1): 93-105.
[6] Galli A, Marciani P, Marku A, et al. Verbascoside protects pancreatic β-cells against ER-stress[J]. Biomedicines, 2020, 8(12): 582.
[7] Wang C, Cai X, Wang R, et al. Neuroprotective effects of verbascoside against Alzheimer’s disease via the relief of endoplasmic reticulum stress in Aβ-exposed U251 cells and APP/PS1 mice[J]. Journal of Neuroinflammation, 2020, 17(1): 309.
[8] Lei P, Lü J, Yao T, et al. Verbascoside exerts an anti-atherosclerotic effect by regulating liver glycerophospholipid metabolism[J]. Food Science and Human Wellness, 2023, 12(6): 2314-2323.
Protocol
| Cell experiment [1]: | |
Cell lines | MCF-7 cells |
Preparation Method | MCF-7 cells were seeded onto 96-well flat-bottomed microculture plates at a density of 5×103 cells/well in DMEM/F-12 medium supplemented with 10% fetal bovine serum, insulin at 4mg/ml, penicillin, and streptomycin (1%) at 37°C, in a 5% CO2 containing humidified chamber. The cells were allowed to adhere to the plates and were treated with various concentrations of Verbascoside (0.1, 0.5, 1, 10, 25, 50, and 100μM) for 24h, and the cell viability was measured. |
Reaction Conditions | 0.1, 0.5, 1, 10, 25, 50, and 100μM; 24h |
Applications | Verbascoside treatment significantly enhanced the cell viability of MCF-7 cells in a dose-dependent manner. |
| Animal experiment [2]: | |
Animal models | APP/PS1 mice |
Preparation Method | APP/PS1 mice (8 weeks old; 40.7-52.9g) were housed in a room with controlled temperature (21-23°C), humidity (40-60%), and lighting (12h light/dark cycle) and were supplied with water. Mice were randomly divided into two groups and given 0.4ml of normal saline (n=12) or 10mg/kg/day of Verbascoside (n=12) orally for 42 days. After the entire 42-day treatment period, all of the mice were euthanized via intraperitoneal injection of sodium pentobarbital (150mg/kg). Collect the brain tissues of mice for analysis. |
Dosage form | 10mg/kg/day for 42 days; p.o. |
Applications | Verbascoside treatment reduced the Aβ deposition and tau protein accumulation within the brain in APP/PS1 mice. |
References: | |
Product Documents
Purity:>99.50%Appearance:A solid
Chemical Properties
CAS No.
61276-17-3
Synonyms
Acteoside, NSC 603831
Chemical Name
[(2R,3R,4R,5R,6R)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
SMILES
CC1C(C(C(C(O1)OC2C(C(OC(C2OC(=O)C=CC3=CC(=C(C=C3)O)O)CO)OCCC4=CC(=C(C=C4)O)O)O)O)O)O
Molecular Formula
C29H36O15
Molecular Weight
624.59
Solubility
DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility
g/mol
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