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Y-27152 Catalog No.GC16690

Prodrug of the Kir6 (KATP) channel opener Y-26763

Size Price Stock Qty
10mg
$302.00
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50mg
$1,268.00
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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 127408-30-4 SDF
Chemical Name N-(benzyloxy)-N-((3S,4R)-6-cyano-3-hydroxy-2,2-dimethylchroman-4-yl)acetamide
Canonical SMILES O[C@@H]1C(C)(C)OC2=C(C=C(C#N)C=C2)[C@H]1N(C(C)=O)OCC3=CC=CC=C3
Formula C21H22N2O4 M.Wt 366.41
Solubility <9.16mg/ml in DMSO; <1.83mg/ml in ethanol Storage Store at RT
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

Y-27152, a prodrug of the KATP (Kir6) channel opener Y-26763, is a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state[1][2].

References:
[1]. Nakajima T, et al. Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state. J Pharmacol Exp Ther. 1992 May;261(2):730-6.
[2]. Fukunari A, et al. Y-26763 protects the canine heart from a stunning injury through opening of the KATP channels. Eur J Pharmacol. 1997 Apr 4;323(2-3):197-204.