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Home >> Signaling Pathways >> GPCR/G protein >> CRFR

CRFR

CRFR (Corticotropin-releasing Factor Receptor), also known as corticotropin-releasing hormone receptor (CRHR), belongs to the G protein-coupled receptor family. There are 3 types of this recetpor, CRF1, CRF2 and CRF3 receptor. CRF1 receptor (CRF1 or CRF1α) is functionally coupled to adenylate cyclase and it belongs to the secretin-like, family B of GPCRs. CRF1 receptor has several splice variants (CRF1c-CRF1m) including CRF1β. CRF2 receptor is a 411-amino acid protein with approximately 70% identity to the known CRF1 and it is functionally coupled to adenylate cyclase. The CRF2 receptor has been shown to be expressed as three functional splice variants, the CRF2α (411-413 amino acids), the CRF2β (431-438 amino acids) and the CRF2γ (397 amino acids). CRF3 receptor is a 428-amino acid protein, which binds CRF with a 5-fold higher affinity than URO and SVG and is expressed in the pituitary gland, urophysis, and brain.

CRFR subserves central functions related to stress physiology, and also exerts peripheral actions relevant to cardiovascular, muscular, gastrointestinal, pancreatic, inflammatory, and neoplastic diseases.

Targets for  CRFR

Products for  CRFR

  1. Cat.No. Product Name Information
  2. GC66088 α-Helical CRF(9-41) TFA α-Helical CRF(9-41) TFA is a competitive CRF2 receptor antagonist with KB of ~100 nM. α-Helical CRF(9-41) TFA is also a partial agonist of CRF1 receptor with an EC50 of 140 nM. α-Helical CRF(9-41) TFA Chemical Structure
  3. GC38886 Antisauvagine-30 TFA Antisauvagine-30 TFA (aSvg-30 TFA) is a potent, highly selective and competitive CRF2 receptor peptidic antagonist. Antisauvagine-30 TFA Chemical Structure
  4. GC50455 Cortagine Potent and selective CRF1 agonist Cortagine Chemical Structure
  5. GC60724 Corticotropin-releasing factor (human) (acetate) Corticotropin-releasing factor human acetate (Human CRF acetate) stimulates the synthesis and secretion of adrenocorticotropin in the anterior pituitary. Corticotropin-releasing factor (human) (acetate) Chemical Structure
  6. GC31043 CP 316311

    CP 316311 is a potent and selective CRF1 receptor antagonist with an IC50 value of 6.8 nM.

     CP 316311 Chemical Structure
  7. GC30863 CP 376395 (CP-316311) CP 376395 (CP-316311) is a potent and selective Corticotropin releasing factor 1 (CRF1) receptor antagonist. CP 376395 (CP-316311) Chemical Structure
  8. GC35748 CRF, bovine CRF, bovine is a potent agonist of CRF receptor, and displaces [125I-Tyr]ovine CRF with a Ki of 3.52 nM. CRF, bovine Chemical Structure
  9. GC34542 CRF, bovine TFA CRF, bovine (TFA) is a potent agonist of CRF receptor, and displaces [125I-Tyr]ovine CRF with a Ki of 3.52 nM. CRF, bovine TFA Chemical Structure
  10. GC31166 Emicerfont (GW876008) Emicerfont (GW876008) is a corticotropin-releasing factor type 1 (CRF1) receptor antagonist with an IC50 of 66 nM. Emicerfont (GW876008) Chemical Structure
  11. GC36787 NVS-CRF38 NVS-CRF38 is a novel corticotropin-releasing factor receptor 1 (CRF1) antagonist with low water solubility. NVS-CRF38 Chemical Structure
  12. GC33712 Pexacerfont (BMS-562086) Pexacerfont (BMS-562086) is a selective corticotropin-releasing factor (CRF1) receptor antagonist with IC50 of 6.1±0.6 nM for human CRF1 receptor. Pexacerfont (BMS-562086) Chemical Structure
  13. GC30792 R121919 (NBI30775) R121919 (NBI30775) (NBI30775) is a potent small-molecule CRF1 receptor antagonist with a Ki of 2 to 5 nM for the CRF1 receptor and over 1000-fold weaker activity at the CRF2 receptor, CRF-binding protein, or 70 other receptor types. R121919 (NBI30775) Chemical Structure
  14. GC65893 Tildacerfont Tildacerfont is a potent and orally active corticotrophin-releasing factor type 1 (CRF1) receptort antagonis. Tildacerfont effectively reduces adrenocorticotropic hormone (ACTH) and adrenal androgen levels. Tildacerfont has favourable safety profile. Tildacerfont can be used for researching congenital adrenal hyperplasia. Tildacerfont Chemical Structure
  15. GC17432 Urocortin (human) Endogenous CRF agonist Urocortin (human) Chemical Structure
  16. GC12802 Urocortin (rat) Endogenous CRF agonist Urocortin (rat) Chemical Structure
  17. GC37868 Urocortin II, human Urocortin II (human) is a selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor. Urocortin II, human Chemical Structure
  18. GC37869 Urocortin III, mouse Urocortin III, mouse is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III, mouse Chemical Structure
  19. GC37870 Urocortin III, mouse (TFA) Urocortin III, mouse (TFA) Chemical Structure
  20. GC32590 Urotensin I (Catostomus urotensin I) Urotensin I (Catostomus urotensin I) (Catostomus urotensin I), a CRF-like neuropeptide, acts as an agonist of CRF receptor with pEC50s of 11.46, 9.36 and 9.85 for human CRF1, human CRF2 and rat CRF2α receptors in CHO cells, and Kis of 0.4, 1.8, and 5.7 nM for hCRF1, rCRF2α and mCRF2β receptors, respectively. Urotensin I (Catostomus urotensin I) Chemical Structure
  21. GC61583 Urotensin I TFA Urotensin I (Catostomus urotensin I) TFA, a CRF-like neuropeptide, acts as an agonist of CRF receptor with pEC50s of 11.46, 9.36 and 9.85 for human CRF1, human CRF2 and rat CRF2α receptors in CHO cells, and Kis of 0.4, 1.8, and 5.7 nM for hCRF1, rCRF2α and mCRF2β receptors, respectively. Urotensin I TFA Chemical Structure
  22. GC19374 Verucerfont Verucerfont is a corticotropin-releasing factor receptor 1 (CRF1) antagonist with IC50s of ~6.1, >1000 and >1000 nM for CRF1, CRF2, and CRF-BP, respectively. Verucerfont Chemical Structure

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