8-Bromo-cGMP, sodium salt (Synonyms: 8-bromo-cGMP, 8-bromo Guanosine 3’,5’-cyclic monophosphate) |
| Catalog No.GC10119 |
8-Bromo-cGMP, sodium salt, a membrane-permeable analogue of cGMP, is a PKG (protein kinase G) activator.
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Cas No.: 51116-01-9
Sample solution is provided at 25 µL, 10mM.
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8-bromo-Cyclic GMP (8-bromo-cGMP) is a cell-permeable analog of cGMP that exhibits greater resistance to hydrolysis by phosphodiesterases than its parent compound. It preferentially activates cGMP-dependent protein kinase.[1] At 1 µM-0.1 mM, 8-bromo-cGMP can inhibit acetylcholine-induced increases in intracellular calcium concentrations.[2]
Reference:
[1]. Rashatwar, S.S., Cornwell, T.L., and Lincoln, T.M. Effects of 8-bromo-cGMP on Ca2+ levels in vascular smooth muscle cells: Possible regulation of Ca2+-ATPase by cGMP-dependent protein kinase. Proceedings of the National Academy of Sciences of the United States of America 84(16), 5685-5689 (1987).
[2]. Choi, J., and Farley, J.M. Effects of 8-bromo-cyclic GMP on membrane potential of single swine tracheal smooth muscle cells. Journal of Pharmacology and Experimental Therapeutics 285(2), 588-594 (1998).
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