δ12-Prostaglandin D2 (Synonyms: Δ12PGD2) |
Catalog No.GC41431 |
Prostaglandin D2 (PGD2) is one of the five primary enzymatic prostaglandins derived directly from PGH2.
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Cas No.: 64072-89-5
Sample solution is provided at 25 µL, 10mM.
Prostaglandin D2 (PGD2) is one of the five primary enzymatic prostaglandins derived directly from PGH2. PGD2 is produced abundantly in the CSF by the lipocalin-type PGD synthase, and in the periphery by myeloid cells including mast cells and basophils by a second, hematopoietic-type PGD synthase. PGD2 is chemically unstable, and its use and analysis is complicated by its short in vivo half-life. δ12-PGD2 is one of the initial chemical decomposition products of PGD2. δ12-PGD2 is an intermediate in the pathway leading to δ12-PGJ2, which is a cyclopentenone prostaglandin with antimitotic and carcinogenic activities. The metabolism of δ12-PGD2 involves addition of thiol nucleophiles, as is the case with the majority of cyclopentenone prostaglandins.
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