CAY10410 (Synonyms: 9,10dihydro15deoxyΔ12,14PGJ2, 9,10dihydro15deoxyΔ12,14Prostaglandin J2) |
| Catalog No.GC40384 |
CAY10410 is an analog of prostaglandin D2/prostaglandin J2 (PGD2/PGJ2) with structural modifications intended to give it PPARγ ligand activity and resistance to metabolism.
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Cas No.: 596104-94-8
Sample solution is provided at 25 µL, 10mM.
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CAY10410 is an analog of prostaglandin D2/prostaglandin J2 (PGD2/PGJ2) with structural modifications intended to give it PPARγ ligand activity and resistance to metabolism. 15-deoxy-δ12,14-PGJ2 has been shown to be a potent ligand for PPARγ. Metabolism of the cyclopentenone prostaglandins PGA2, PGJ2, and δ12-PGJ2 occurs via glutathione addition across the α,β unsaturated enone. CAY10410 was designed as an analog of the PPARγ-binding prostaglandins which could not undergo this conjugation reaction. In human neuroblastoma SH-SY5Y cells, CAY10410 was not cytotoxic at up to 25 µM. It also failed to covalently modify thioredoxin or induce oxidative stress at 50 µM.
Average Rating: 5 (Based on Reviews and 29 reference(s) in Google Scholar.)
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