DMP 543 |
| Catalog No.GC11429 |
K+ channel blocker and acetylcholine release stimulator
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 160588-45-4
Sample solution is provided at 25 µL, 10mM.
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DMP-543 (XR-543) is a KV7 channel blocker, also acts as a potent neurotransmitter release enhancer[1][2].
DMP-543 enhances [3H]ACh release from rat brain slices, with an EC50 of 700 nM[2].
References:
[1]. Ipavec V, et al. KV7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fundus. Pharmacol Res. 2011 Oct;64(4):397-409.
[2]. Zaczek R, et al. Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J Pharmacol Exp Ther. 1998 May;285(2):724-30.
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