Soyasapogenol B |
Catalog No.GC37669
One-Click Copy Product Info
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Soyasapogenol B is a soy-derived component with multiple biological activities.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 595-15-3
Sample solution is provided at 25 µL, 10mM.
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Soyasapogenol B is a soy-derived component with multiple biological activities. Soyasapogenol B can modulate cellular autophagy, apoptosis, inflammation, and oxidative damage[1-2]. Soyasapogenol B is applicable for research related to colorectal cancer, clear cell renal cell carcinoma, and neurodegenerative diseases[3-4].
In vitro, Soyasapogenol B (0.5-3mM) incubation with Caco-2 cells for 4 hours. Soyasapogenol B significantly inhibited epithelial sodium channel (ENaC)-mediated sodium absorption. The uptake of Soyasapogenol B in Caco-2 cells was concentration-dependent, and Soyasapogenol B inhibited cell viability[5]. Treatment of differentiated 3T3-L1 adipocytes with Soyasapogenol B (6.25-12.5μM) for 10 days. Soyasapogenol B significantly reduced intracellular triglyceride content while increasing the levels of glycerol and free fatty acids in the culture medium[6].
In vivo, dietary administration of Soyasapogenol B (0.02%; mixed in feed) to 12-week-old male C57BL/6 mice for 8 weeks significantly increased the animals' grip strength, exercise endurance, and the weights of the quadriceps and gastrocnemius muscles[7]. In 6-week-old male ICR mice, Soyasapogenol B (10mg/kg) was orally administered once daily for 3 days, starting 24 hours after the seventh intraperitoneal injection of LPS (8μg/kg). Soyasapogenol B significantly restored the LPS-induced impairments in spontaneous alternation behavior and latency time, increased the expression of brain-derived neurotrophic factor (BDNF) and CREB phosphorylation in the hippocampus, and inhibited NF-κB activation and TNF-α expression[8].
References:
[1] Sasaki K, Minowa N, Kuzuhara H, et al. Preventive effects of soyasapogenol B derivatives on liver injury in a concanavalin A-induced hepatitis model. Bioorg Med Chem. 2005 Aug 15;13(16):4900-11.
[2] Yun HM, Lee JY, Kim SH, et al. Effects of Triterpene Soyasapogenol B from Arachis hypogaea (Peanut) on Differentiation, Mineralization, Autophagy, and Necroptosis in Pre-Osteoblasts. Int J Mol Sci. 2022 Jul 27;23(15):8297.
[3] Zhang W, Popovich DG. Effect of soyasapogenol A and soyasapogenol B concentrated extracts on HEP-G2 cell proliferation and apoptosis. J Agric Food Chem. 2008 Apr 23;56(8):2603-8.
[4] Evidente A, Cimmino A, Fernández-Aparicio M, et al. Soyasapogenol B and trans-22-dehydrocam- pesterol from common vetch (Vicia sativa L.) root exudates stimulate broomrape seed germination. Pest Manag Sci. 2011 Aug;67(8):1015-22.
[5] Hu J, Reddy MB, Hendrich S, et al. Soyasaponin I and sapongenol B have limited absorption by Caco-2 intestinal cells and limited bioavailability in women. J Nutr. 2004 Aug;134(8):1867-73.
[6] Iwamoto K, Kamo S, Takada Y, et al. Soyasapogenols reduce cellular triglyceride levels in 3T3-L1 mouse adipocyte cells by accelerating triglyceride lipolysis. Biochem Biophys Rep. 2018 Sep 27;16:44-49.
[7] Ahn BM, Noh Y, Lee JJ, et al. Soyasapogenol B prevents sarcopenia by increasing skeletal muscle mass and function through the Sirt1/PGC-1α and PI3K pathway. Biomed Pharmacother. 2025 Aug;189:118316.
[8] Lee HJ, Lim SM, Ko DB, et al. Soyasapogenol B and Genistein Attenuate Lipopolysaccharide-Induced Memory Impairment in Mice by the Modulation of NF-κB-Mediated BDNF Expression. J Agric Food Chem. 2017 Aug 16;65(32):6877-6885.
| Cell experiment [1]: | |
Cell lines | 3T3-L1 mouse preadipocyte cells |
Preparation Method | 3T3-L1 cells were maintained in Dulbecco's modified Eagle medium (DMEM) supplemented with 10% fetal bovine serum (FBS) at 37°C under 5% CO₂. Differentiation into adipocytes was induced using a reagent containing insulin, dexamethasone, and 3-isobutyl-1-methylxanthine. Differentiated adipocytes were then treated with Soyasapogenol B (6.25-12.5µM). |
Reaction Conditions | 6.25-12.5µM; 10 days. |
Applications | Soyasapogenol B significantly reduced the cellular triglyceride content. Soyasapogenol B increased the levels of glycerol and free fatty acids in the culture medium. Soyasapogenol B did not alter the protein expression level of adipose triglyceride lipase (ATGL). Soyasapogenol B increased the secretion of adiponectin and significantly decreased the secretion of resistin. |
| Animal experiment [2]: | |
Animal models | ICR mice |
Preparation Method | Mice were intraperitoneally injected with LPS (8μg/kg) once a day for 7 times. Oral administration of Soyasapogenol B (10mg/kg) began 24 hours after the seventh LPS injection and was continued once daily for 3 days. Memory behavior was measured 18 hours after the final administration of the test agent. |
Dosage form | 10mg/kg; p.o.; once daily for 3 days. |
Applications | Soyasapogenol B significantly restored LPS-impaired spontaneous alternation behavior and latency time. Soyasapogenol B increased brain-derived neurotrophic factor (BDNF) expression and CREB phosphorylation in the hippocampus. Soyasapogenol B inhibited NF-κB activation and TNF-α expression in the hippocampus. |
References: | |
| Cas No. | 595-15-3 | SDF | |
| Canonical SMILES | C[C@]12[C@]3(C([C@@]4([H])[C@](C)([C@@H](CC(C)(C)C4)O)CC3)=CC[C@]1([H])[C@@]5([C@@]([C@](C)([C@@H](O)CC5)CO)([H])CC2)C)C | ||
| Formula | C30H50O3 | M.Wt | 458.72 |
| Solubility | DMSO : 50 mg/mL (109.00 mM; Need ultrasonic) | Storage | 4°C, protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.18 mL | 10.8999 mL | 21.7998 mL |
| 5 mM | 436 μL | 2.18 mL | 4.36 mL |
| 10 mM | 218 μL | 1.09 mL | 2.18 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.50% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)