[Sar9,Met(O2)11]-Substance P TFA |
| Catalog No.GC38013 |
[Sar9,Met(O2)11]-Substance P TFA is a tachykinin NK1 receptor selective agonist.
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![[Sar9,Met(O2)11]-Substance P TFA Chemical Structure](/media/struct/GC3/GC38013.png "[Sar9,Met(O2)11]-Substance P TFA Chemical Structure")
Cas No.: 2828433-10-7
Sample solution is provided at 25 µL, 10mM.
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[Sar9,Met(O2)11]-Substance P TFA is a tachykinin NK1 receptor selective agonist.
[Sar9,Met(O2)11]-Substance P and septide (10-100 pmol per rat, i.c.v.) are equipotent in increasing mean arterial blood pressure (MAP) and heart rate (HR), yet they have dissimilar time-course. Both agonists increase dose-dependently face washing and sniffing while [Sar9,Met(O2)11]-Substance P is the sole to produce grooming[1].
[1]. Cellier E, et al. Characterization of central and peripheral effects of septide with the use of five tachykinin NK1 receptor antagonists in the rat. Br J Pharmacol. 1999 Jun;127(3):717-28.
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