Ketoprofen (Synonyms: (R,S)-Ketoprofen, 2-(3-benzoylphenyl)Propionic Acid) |
| Catalog No.GC13339 |
Dual COX1/2 inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 22071-15-4
Sample solution is provided at 25 µL, 10mM.
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Ketoprofen (RP-19583) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively.
Ketoprofen (Compound 2) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively[1].
Ketoprofen (RP-19583) (0.32-10 mg/kg, s.c) dose-dependently inhibits acid-induced depression of nesting (IC50, 2.05 mg/kg), and reverses CFA-induced such depression at 0.1-10 mg/kg, with an IC50 of 0.18 mg/kg in mice[2].
References:
[1]. Palomer A, et al. Structure-based design of cyclooxygenase-2 selectivity into ketoprofen. Bioorg Med Chem Lett. 2002 Feb 25;12(4):533-7.
[2]. Negus SS, et al. Effects of ketoprofen, morphine, and kappa opioids on pain-related depression of nesting in mice. Pain. 2015 Jun;156(6):1153-60.
Average Rating: 5 (Based on Reviews and 25 reference(s) in Google Scholar.)
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