KH 7 |
| Catalog No.GC16334 |
soluble adenylyl cyclase (sAC) inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 330676-02-3
Sample solution is provided at 25 µL, 10mM.
Product has been cited by 1 publications
Product Documents
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
KH7 is a soluble adenylyl cyclase (sAC)-specific inhibitor, with IC50s of 3-10 μM toward both recombinant purified human sACt protein and heterologously expressed sACt in cellular assays[1].
References:
[1]. Hess KC, et al. The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilization. Dev Cell. 2005 Aug;9(2):249-59.
| Cas No. | 330676-02-3 | SDF | |
| Chemical Name | (S,Z)-2-((1H-benzo[d]imidazol-2-yl)thio)-N'-((3-bromo-6-oxocyclohexa-2,4-dien-1-ylidene)methyl)propanehydrazide | ||
| Canonical SMILES | BrC1=C/C(C(C=C1)=O)=C/NNC([C@H](C)SC2=NC3=CC=CC=C3N2)=O | ||
| Formula | C17H15BrN4O2S | M.Wt | 419.3 |
| Solubility | 25 mg/ml in DMSO, 30 mg/ml in DMF, 0.5 mg/ml in Ethanol | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
Complete Stock Solution Preparation Table
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.3849 mL | 11.9246 mL | 23.8493 mL |
| 5 mM | 0.477 mL | 2.3849 mL | 4.7699 mL |
| 10 mM | 0.2385 mL | 1.1925 mL | 2.3849 mL |
In vivo Formulation Calculator (Clear solution)
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Related Products
- GC11574 HPOB
- GC33703 3,4,5-Trimethoxycinnamic acid
- GC18100 Illudin S
- GC12565 Ro 26-4550 trifluoroacetate
- GC31037 Clocapramine (Clocarpramine)
- GC36547 Mast Cell Degranulating Peptide HR-2
- GC16760 WS 12
- GC16555 TAK-875
- GC61825 Bismuth subcarbonate
- GC41425 8-iso Prostaglandin E2
- GC17009 L-trans-2,4-PDC
- GC40107 6-fluoro DET
- GC50703 Yhhu 3792
- GC15351 PF-9184
- GC44669 POV-PC
- GC14683 Sunitinib malate
- GC50215 BA 1
Reviews
Average Rating: 5 ★★★★★ (Based on Reviews and 31 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *