NPC-15437 (hydrochloride) |
| Catalog No.GC18935 |
NPC-15437 is a selective protein kinase C (PKC) inhibitor (IC50 = 19 uM).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 141774-20-1
Sample solution is provided at 25 µL, 10mM.
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NPC-15437 is a selective protein kinase C (PKC) inhibitor (IC50 = 19 uM). It competitively inhibits phorbol ester- (Ki = 5 uM) and phosphatidylserine-induced (Ki = 12 uM) PKC activity but does not affect the activity of cAMP-dependent or Ca2+/calmodulin-dependent protein kinases. PKC signaling is involved in learning and memory, and when NPC-15437 was administered after Y maze training (0.1-10 mg/kg i.p.), it led to memory retention deficits in mice.
Review for NPC-15437 (hydrochloride)
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)
Review for NPC-15437 (hydrochloride)
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