p-MPPI hydrochloride |
| Catalog No.GC60293 |
p-MPPI hydrochloride is a selective 5-HT1A receptor antagonist with high affinity for 5-HT1A receptors.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 220643-77-6
Sample solution is provided at 25 µL, 10mM.
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p-MPPI hydrochloride is a selective 5-HT1A receptor antagonist with high affinity for 5-HT1A receptors. p-MPPI hydrochloride can crosses the blood-brain barrier, and has clear antidepressant and anxiolytic-like effects[1][2].
p-MPPI hydrochloride has no agonist activity in both in vitro and in vivo tests of pre- and post-synaptic 5-HT1A receptor activity[1].
p-MPPI hydrochloride (0.5-4.5 mg/kg; i.p.) shows anxiolytic-like profile in the murine elevated plus-maze[2]. Animal Model: Adult male Swiss Webster mice (aged 8-9 weeks)[2]
[1]. SØrensen E, et al. The selective 5-HT(1A) receptor antagonist p-MPPI antagonizes sleep--waking and behavioural effects of 8-OH-DPAT in rats. Behav Brain Res. 2001 Jun;121(1-2):181-7. [2]. Cao BJ, et al. Anxiolytic-like profile of p-MPPI, a novel 5HT1A receptor antagonist, in the murine elevated plus-maze. Psychopharmacology (Berl). 1997 Feb;129(4):365-71.
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