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PluriSIn #2

Catalog No.GC61531

PluriSIn #2 Chemical Structure

Size Price Stock Qty
5 mg
$232.00
In stock
10 mg
$417.00
In stock
25 mg
$788.00
In stock
50 mg
$1,251.00
In stock
100 mg
$1,808.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Quality Control

Quality Control & SDS

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Background

PluriSIn #2 is a selective transcriptional inhibitor of topoisomerase II α (TOP2A). PluriSIn #2 is a compound that selectively eliminates undifferentiated human pluripotent stem cells (hPSCs)[1].

PluriSIn #2 (20 µM; 12 hours) treatment reduces TOP2A expression at the protein level[1].A 24h exposure of PluriSIn #2 (20 µM) is sufficient to induce massive cell death in hPSCs, but doesn't affect the viability of various other cell types derived from them[1]. Western Blot Analysis[1] Cell Line: B153 and HUES9 human pluripotent stem cells (hPSCs)

[1]. Uri Ben-David, et al. Brief reports: Controlling the survival of human pluripotent stem cells by small molecule-based targeting of topoisomerase II alpha. Stem Cells. 2015 Mar;33(3):1013-9.

Chemical Properties

Cas No. 56563-17-8 SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES O=C(N(C(N1)=O)C=C(F)C1=O)NC2=CC=CC=C2
Formula C11H8FN3O3 M.Wt 249.2
Solubility DMSO: 5 mg/mL (20.06 mM) Storage 4°C, protect from light, stored under nitrogen
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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