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iGluR

iGluR (ionotropic glutamate receptor) is a ligand-gated ion channel that is activated by the neurotransmitter glutamate. iGluR are integral membrane proteins compose of four large subunits that form a central ion channel pore. Sequence similarity among all known glutamate receptor subunits, including the AMPA, kainate, NMDA, and δ receptors.

AMPA receptors are the main charge carriers during basal transmission, permitting influx of sodium ions to depolarise the postsynaptic membrane. NMDA receptors are blocked by magnesium ions and therefore only permit ion flux following prior depolarisation. This enables them to act as coincidence detectors for synaptic plasticity. Calcium influx through NMDA receptors leads to persistent modifications in the strength of synaptic transmission.

Targets for  iGluR

Products for  iGluR

  1. Cat.No. Product Name Information
  2. GC18033 γDGG glutamate receptor antagonist γDGG  Chemical Structure
  3. GC11889 (S)-(-)-5-Fluorowillardiine AMPA receptor agonist (S)-(-)-5-Fluorowillardiine  Chemical Structure
  4. GC34998 (S)-(-)-5-Fluorowillardiine hydrochloride (S)-(-)-5-Fluorowillardiine hydrochloride  Chemical Structure
  5. GC30212 (S)-Willardiine ((-)-Willardiine) (S)-Willardiine ((-)-Willardiine)  Chemical Structure
  6. GC12863 1-BCP potentiator of AMPA-mediated responses 1-BCP  Chemical Structure
  7. GC33673 24-Hydroxycholesterol 24-Hydroxycholesterol  Chemical Structure
  8. GC31309 6-Methoxy-2-naphthoic acid (Naproxen impurity O) 6-Methoxy-2-naphthoic acid (Naproxen impurity O)  Chemical Structure
  9. GC10781 7-Chlorokynurenic acid NMDA receptor glycine site antagonist 7-Chlorokynurenic acid  Chemical Structure
  10. GC11395 7-Chlorokynurenic acid sodium salt NMDA receptor antagonist acting at the glycine site 7-Chlorokynurenic acid sodium salt  Chemical Structure
  11. GC13164 Ampalex Ampakine and nootropic Ampalex  Chemical Structure
  12. GC17695 Aniracetam Nootropic drug for senile dementia Aniracetam  Chemical Structure
  13. GC30911 Apimostinel (NRX-1074) Apimostinel (NRX-1074)  Chemical Structure
  14. GC38497 ATPA ATPA  Chemical Structure
  15. GC33723 Becampanel (AMP 397) Becampanel (AMP 397)  Chemical Structure
  16. GC18079 CFM-2 AMPA antagonist CFM-2  Chemical Structure
  17. GC38493 CGP 37849 CGP 37849  Chemical Structure
  18. GC14414 CIQ NMDA receptor potentiator CIQ  Chemical Structure
  19. GC13290 CMPDA positive allosteric modulator of AMPA receptors CMPDA  Chemical Structure
  20. GC11799 CNQX AMPA/kainate receptor antagonist CNQX  Chemical Structure
  21. GC32553 CNS-5161 hydrochloride (CNS 5161A) CNS-5161 hydrochloride (CNS 5161A)  Chemical Structure
  22. GC16899 Coluracetam Nootropic agent of the racetam family Coluracetam  Chemical Structure
  23. GC14495 CX 546 AMPA receptor potentiator CX 546  Chemical Structure
  24. GC64244 CX 717 CX 717  Chemical Structure
  25. GC16315 D-AP5

    A NMDA antagonist

    D-AP5  Chemical Structure
  26. GC63881 DL-Phenylalanine-d5 hydrochloride DL-Phenylalanine-d5 hydrochloride  Chemical Structure
  27. GC32755 DNQX (FG 9041) A nonNMDA glutamate receptor antagonist DNQX (FG 9041)  Chemical Structure
  28. GC35917 Dynorphin A (1-10) TFA Dynorphin A (1-10) TFA  Chemical Structure
  29. GC35918 Dynorphin A 1-10 Dynorphin A 1-10  Chemical Structure
  30. GC15343 Eliprodil NMDA receptor antagonist Eliprodil  Chemical Structure
  31. GC36027 Fanapanel hydrate Fanapanel hydrate  Chemical Structure
  32. GC18223 Farampator Farampator is a positive allosteric modulator of AMPA receptors that has an EC50 value greater than 32 uM for evoking glutamate currents in isolated pyramidal neurons. Farampator  Chemical Structure
  33. GC10522 Felbamate antagonist at the NMDA-associated glycine binding site Felbamate  Chemical Structure
  34. GC15363 Felbamate hydrate N-methyl-D-aspartate (NMDA) inhibitor Felbamate hydrate  Chemical Structure
  35. GC36060 Flupirtine Flupirtine  Chemical Structure
  36. GC11470 Flupirtine maleate NMDA receptor antagonist Flupirtine maleate  Chemical Structure
  37. GC64245 Glycine-13C2 Glycine-13C2  Chemical Structure
  38. GC64249 Glycine-15N Glycine-15N  Chemical Structure
  39. GC14121 GLYX 13 NMDA receptor partial agonist GLYX 13  Chemical Structure
  40. GC31270 GNE 0723 GNE 0723  Chemical Structure
  41. GC31076 GNE 5729 GNE 5729  Chemical Structure
  42. GC31019 GV-196771A GV-196771A  Chemical Structure
  43. GC14842 GYKI 53655 hydrochloride AMPA and kainate receptor antagonist GYKI 53655 hydrochloride  Chemical Structure
  44. GA11338 H-D-Asp-OH H-D-Asp-OH H-D-Asp-OH  Chemical Structure
  45. GA11306 H-D-Ser-OH H-D-Ser-OH H-D-Ser-OH  Chemical Structure
  46. GA10750 H-Glu-OH H-Glu-OH H-Glu-OH  Chemical Structure
  47. GA10922 H-Gly-OH

    H-Gly-OH

    H-Gly-OH  Chemical Structure
  48. GC11715 Ibotenic acid NMDA and metabotropic glutamate receptor agonist Ibotenic acid  Chemical Structure
  49. GC30847 IC87201 IC87201  Chemical Structure
  50. GC12521 Ifenprodil Tartrate NMDA receptor antagonist Ifenprodil Tartrate  Chemical Structure
  51. GC34638 JNJ-61432059 JNJ-61432059  Chemical Structure
  52. GC14533 Kynurenic acid broad spectrum EAA antagonist Kynurenic acid  Chemical Structure
  53. GC36411 Kynurenic acid sodium Kynurenic acid sodium  Chemical Structure
  54. GC14810 L-701,324 NMDA receptor antagonist L-701,324  Chemical Structure
  55. GC30788 L-Glutamic acid monosodium salt (Monosodium glutamate) L-Glutamic acid monosodium salt (Monosodium glutamate)  Chemical Structure
  56. GC64352 L-Glutamic acid-15N L-Glutamic acid-15N  Chemical Structure
  57. GC64148 L-Phenylalanine-15N L-Phenylalanine-15N  Chemical Structure
  58. GC63982 L-Phenylalanine-d5 L-Phenylalanine-d5  Chemical Structure
  59. GC64290 L-Phenylalanine-d8 L-Phenylalanine-d8  Chemical Structure
  60. GC11124 Lanicemine

    voltage-dependent NMDA channel blocker

    Lanicemine  Chemical Structure
  61. GN10122 Linalool Extracted from Cinnamomum camphora (L.) Presl.;Store the product in sealed, cool and dry condition Linalool  Chemical Structure
  62. GC36515 LY450108 LY450108  Chemical Structure
  63. GC13010 LY451395 Allosteric modulator LY451395  Chemical Structure
  64. GC30951 MDL 105519 MDL 105519  Chemical Structure
  65. GC14039 MDL-29951 Glycine antagonist of NMDA receptor activation MDL-29951  Chemical Structure
  66. GC10443 Meclofenoxate hydrochloride Drug for senile dementia and AD treatment Meclofenoxate hydrochloride  Chemical Structure
  67. GC10198 Memantine hydrochloride NMDA receptor antagonist Memantine hydrochloride  Chemical Structure
  68. GC30973 Mephenesin Mephenesin  Chemical Structure
  69. GC31036 MRZ 2-514 MRZ 2-514  Chemical Structure
  70. GC33668 Naspm (1-Naphthylacetyl spermine) Naspm (1-Naphthylacetyl spermine)  Chemical Structure
  71. GC13349 Naspm trihydrochloride Ca2+-permeable AMPA receptor antagonist Naspm trihydrochloride  Chemical Structure
  72. GC14156 NBQX AMPA receptor antagonist NBQX  Chemical Structure
  73. GC30860 Neu2000 Neu2000  Chemical Structure
  74. GC17456 NMDA (N-Methyl-D-aspartic acid) NMDA receptor agonist NMDA (N-Methyl-D-aspartic acid)  Chemical Structure
  75. GC34352 NMDAR antagonist 1 NMDAR antagonist 1  Chemical Structure
  76. GC10270 Noopept Nootropic and neuroprotective agent Noopept  Chemical Structure
  77. GC64133 NS-102 NS-102  Chemical Structure
  78. GC33740 NT 13 (TPPT) NT 13 (TPPT)  Chemical Structure
  79. GC30852 Org-26576 Org-26576  Chemical Structure
  80. GC13779 Orphenadrine Citrate Antiparkinsonian and analgesic drug Orphenadrine Citrate  Chemical Structure
  81. GC33701 Orphenadrine hydrochloride Orphenadrine hydrochloride  Chemical Structure
  82. GC16562 PEAQX NMDA antagonist PEAQX  Chemical Structure
  83. GC36865 PEAQX tetrasodium hydrate PEAQX tetrasodium hydrate  Chemical Structure
  84. GC13007 PEPA Novel allosteric potentiator of AMPA receptor desensitization PEPA  Chemical Structure
  85. GC36876 Perzinfotel Perzinfotel  Chemical Structure
  86. GC14492 PF 4778574 positive allosteric modulator of AMPA receptors PF 4778574  Chemical Structure
  87. GC12703 Philanthotoxin 74 AMPA receptor antagonist Philanthotoxin 74  Chemical Structure
  88. GC13469 Piracetam cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA) Piracetam  Chemical Structure
  89. GC30946 Procyclidine hydrochloride ((±)-Procyclidine hydrochlorid) Procyclidine hydrochloride ((±)-Procyclidine hydrochlorid)  Chemical Structure
  90. GC16776 QNZ 46 NR2C/NR2D-selective NMDA receptor antagonist QNZ 46  Chemical Structure
  91. GC14547 Quinolinic acid NMDA agonist Quinolinic acid  Chemical Structure
  92. GC34753 Radiprodil Radiprodil  Chemical Structure
  93. GC33492 Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate) Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate)  Chemical Structure
  94. GC30835 Rislenemdaz (MK-0657) Rislenemdaz (MK-0657)  Chemical Structure
  95. GC19310 Ro 25-6981 Ro 25-6981 is a potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit. Ro 25-6981  Chemical Structure
  96. GC18410 Ro 25-6981 (maleate) Ro 25-6981 (maleate) is a potent, selective activity-dependent blocker of NMDA receptors containing the NR2B subunit (IC50s = 9 nM and 52 μM for cloned receptor subunit combinations NR1C/NR2B and NR1C/NR2A, respectively). Ro 25-6981 (maleate)  Chemical Structure
  97. GC31039 RPR104632 RPR104632  Chemical Structure
  98. GC13684 S 18986 positive allosteric modulator of AMPA receptors S 18986  Chemical Structure
  99. GC18118 SDZ 220-581 NMDA glutamate receptor subtype antagonist SDZ 220-581  Chemical Structure
  100. GC37612 SDZ 220-581 Ammonium salt SDZ 220-581 Ammonium salt  Chemical Structure
  101. GC16986 SDZ 220-581 hydrochloride NMDA receptor antagonist SDZ 220-581 hydrochloride  Chemical Structure

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