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Home >> Signaling Pathways >> Neuroscience >> iGluR

iGluR

iGluR (ionotropic glutamate receptor) is a ligand-gated ion channel that is activated by the neurotransmitter glutamate. iGluR are integral membrane proteins compose of four large subunits that form a central ion channel pore. Sequence similarity among all known glutamate receptor subunits, including the AMPA, kainate, NMDA, and δ receptors.

AMPA receptors are the main charge carriers during basal transmission, permitting influx of sodium ions to depolarise the postsynaptic membrane. NMDA receptors are blocked by magnesium ions and therefore only permit ion flux following prior depolarisation. This enables them to act as coincidence detectors for synaptic plasticity. Calcium influx through NMDA receptors leads to persistent modifications in the strength of synaptic transmission.

Products for  iGluR

  1. Cat.No. Product Name Information
  2. GC18033 γDGG γDGG is a competitive AMPA receptor blocker. γDGG Chemical Structure
  3. GC11889 (S)-(-)-5-Fluorowillardiine AMPA receptor agonist (S)-(-)-5-Fluorowillardiine Chemical Structure
  4. GC34998 (S)-(-)-5-Fluorowillardiine hydrochloride (S)-(-)-5-Fluorowillardiine hydrochloride is a potent and specific AMPAR agonist. (S)-(-)-5-Fluorowillardiine hydrochloride Chemical Structure
  5. GC30212 (S)-Willardiine ((-)-Willardiine) (S)-Willardiine ((-)-Willardiine) is a potent agonist of AMPA/kainate receptors with EC50 of 44.8 uM. (S)-Willardiine ((-)-Willardiine) Chemical Structure
  6. GC12863 1-BCP potentiator of AMPA-mediated responses 1-BCP Chemical Structure
  7. GC33673 24-Hydroxycholesterol 24-Hydroxycholesterol is a natural sterol, which serves as a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factors LXR. 24-Hydroxycholesterol Chemical Structure
  8. GC31309 6-Methoxy-2-naphthoic acid (Naproxen impurity O) 6-Methoxy-2-naphthoic acid (Naproxen impurity O) is an NMDA receptor modulator extracted from patent WO 2012019106 A2. 6-Methoxy-2-naphthoic acid (Naproxen impurity O) Chemical Structure
  9. GC10781 7-Chlorokynurenic acid NMDA receptor glycine site antagonist 7-Chlorokynurenic acid Chemical Structure
  10. GC11395 7-Chlorokynurenic acid sodium salt NMDA receptor antagonist acting at the glycine site 7-Chlorokynurenic acid sodium salt Chemical Structure
  11. GC68438 AMPA receptor modulator-3 AMPA receptor modulator-3 Chemical Structure
  12. GC17695 Aniracetam Nootropic drug for senile dementia Aniracetam Chemical Structure
  13. GC30911 Apimostinel (NRX-1074) Apimostinel (NRX-1074) (NRX-1074; AGN-241660) is an orally active NMDA receptor partial agonist. Apimostinel (NRX-1074) Chemical Structure
  14. GC38497 ATPA ATPA Chemical Structure
  15. GC33723 Becampanel (AMP 397) Becampanel (AMP 397) (AMP397) is the first competitive AMPA antagonist and an antiepileptic agent. Becampanel (AMP 397) Chemical Structure
  16. GC64574 BZAD-01 BZAD-01 is a potent, selective and orally active inhibitor of NMDA NR2B subunit, with a Ki of 72 nM. BZAD-01 Chemical Structure
  17. GC18079 CFM-2 AMPA antagonist CFM-2 Chemical Structure
  18. GC38493 CGP 37849 CGP 37849 Chemical Structure
  19. GC14414 CIQ NMDA receptor potentiator CIQ Chemical Structure
  20. GC13290 CMPDA positive allosteric modulator of AMPA receptors CMPDA Chemical Structure
  21. GC11799 CNQX AMPA/kainate receptor antagonist CNQX Chemical Structure
  22. GC32553 CNS-5161 hydrochloride (CNS 5161A) CNS-5161 hydrochloride (CNS 5161A) is a novel NMDA ion-channel antagonist that interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the actions of glutamate. CNS-5161 hydrochloride (CNS 5161A) Chemical Structure
  23. GC16899 Coluracetam Nootropic agent of the racetam family Coluracetam Chemical Structure
  24. GC14495 CX 546 AMPA receptor potentiator CX 546 Chemical Structure
  25. GC64244 CX 717 CX 717 is a positive allosteric modulator of AMPA receptor. CX 717 Chemical Structure
  26. GC16315 D-AP5

    A NMDA antagonist

     D-AP5 Chemical Structure
  27. GC63881 DL-Phenylalanine-d5 hydrochloride DL-Phenylalanine-d5 hydrochloride Chemical Structure
  28. GC32755 DNQX (FG 9041) DNQX (FG 9041) (FG 9041), a quinoxaline derivative, is a selective, potent competitive non-NMDA glutamate receptor antagonist (IC50s = 0.5, 2 and 40 μM for AMPA, kainate and NMDA receptors, respectively). DNQX (FG 9041) Chemical Structure
  29. GC35917 Dynorphin A (1-10) TFA Dynorphin A (1-10) TFA Chemical Structure
  30. GC35918 Dynorphin A 1-10 Dynorphin A 1-10 an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A 1-10 Chemical Structure
  31. GC15343 Eliprodil NMDA receptor antagonist Eliprodil Chemical Structure
  32. GC36027 Fanapanel hydrate Fanapanel hydrate (ZK200775 hydrate) is a highly selective AMPA/kainate antagonist with little activity against NMDA; have Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively. Fanapanel hydrate Chemical Structure
  33. GC18223 Farampator Farampator is a positive allosteric modulator of AMPA receptors that has an EC50 value greater than 32 uM for evoking glutamate currents in isolated pyramidal neurons. Farampator Chemical Structure
  34. GC10522 Felbamate antagonist at the NMDA-associated glycine binding site Felbamate Chemical Structure
  35. GC15363 Felbamate hydrate N-methyl-D-aspartate (NMDA) inhibitor Felbamate hydrate Chemical Structure
  36. GC36060 Flupirtine Flupirtine(D 9998) is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties. Flupirtine Chemical Structure
  37. GC11470 Flupirtine maleate NMDA receptor antagonist Flupirtine maleate Chemical Structure
  38. GC64245 Glycine-13C2 Glycine-13C2 Chemical Structure
  39. GC64249 Glycine-15N Glycine-15N Chemical Structure
  40. GC14121 GLYX 13 GLYX 13 (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator that has characteristics of a glycine site partial agonist. GLYX 13 Chemical Structure
  41. GC31270 GNE 0723 GNE 0723 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 21 nM for GluN2A, 7.4 and 6.2 μM for GluN2C and GluN2D, respectively. GNE 0723 Chemical Structure
  42. GC31076 GNE 5729 GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively. GNE 5729 Chemical Structure
  43. GC31019 GV-196771A GV-196771A is the sodium salt form of GV196771, is an NMDA receptor antagonist. GV-196771A Chemical Structure
  44. GC14842 GYKI 53655 hydrochloride AMPA and kainate receptor antagonist GYKI 53655 hydrochloride Chemical Structure
  45. GC11715 Ibotenic acid NMDA and metabotropic glutamate receptor agonist Ibotenic acid Chemical Structure
  46. GC30847 IC87201 An inhibitor of the nNOS-PSD-95 protein-protein interaction IC87201 Chemical Structure
  47. GC12521 Ifenprodil Tartrate NMDA receptor antagonist Ifenprodil Tartrate Chemical Structure
  48. GC34638 JNJ-61432059 JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with a pIC50 of 9.7 for GluA1/γ-8. JNJ-61432059 Chemical Structure
  49. GC36411 Kynurenic acid sodium Kynurenic acid sodium Chemical Structure
  50. GC14810 L-701,324 NMDA receptor antagonist L-701,324 Chemical Structure
  51. GC30788 L-Glutamic acid monosodium salt (Monosodium glutamate) L-Glutamic acid monosodium salt (Monosodium glutamate) acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid monosodium salt (Monosodium glutamate) Chemical Structure
  52. GC64352 L-Glutamic acid-15N L-Glutamic acid-15N Chemical Structure
  53. GC65095 L-Glutamic acid-d5 L-Glutamic acid-d5 is the deuterium labeled L-Glutamic acid. L-Glutamic acid-d5 Chemical Structure
  54. GC66843 L-Homocysteic acid L-Homocysteic acid (L-HCA) is an endogenous excitatory amino acid that acts as a NMDA receptor agonist (EC50: 14 μM). L-Homocysteic acid is neurotoxic, and can be used in the research of neurological disorders. L-Homocysteic acid Chemical Structure
  55. GC64148 L-Phenylalanine-15N L-Phenylalanine-15N Chemical Structure
  56. GC65050 L-Phenylalanine-d2 L-Phenylalanine-d2 Chemical Structure
  57. GC63982 L-Phenylalanine-d5 L-Phenylalanine-d5 Chemical Structure
  58. GC64290 L-Phenylalanine-d8 L-Phenylalanine-d8 Chemical Structure
  59. GC11124 Lanicemine

    voltage-dependent NMDA channel blocker

     Lanicemine Chemical Structure
  60. GC36510 LY3130481 LY3130481 is an AMPA receptor antagonist that is dependent upon transmembrane AMPA receptor regulatory protein (TARP) γ-8, selective inhibits AMPA/TARP γ-8 with an IC50 of 65 nM. LY3130481 Chemical Structure
  61. GC36515 LY450108 LY450108 is a potent AMPA receptor potentiator. LY450108 Chemical Structure
  62. GC13010 LY451395 LY451395 (LY451395) is a potent and highly selective potentiator of the AMPA receptors. LY451395 Chemical Structure
  63. GC30951 MDL 105519 MDL 105519 is a potent and selective antagonist of glycine binding to the NMDA receptor. MDL 105519 Chemical Structure
  64. GC14039 MDL-29951 Glycine antagonist of NMDA receptor activation MDL-29951 Chemical Structure
  65. GC10443 Meclofenoxate hydrochloride Drug for senile dementia and AD treatment Meclofenoxate hydrochloride Chemical Structure
  66. GC10198 Memantine hydrochloride NMDA receptor antagonist Memantine hydrochloride Chemical Structure
  67. GC30973 Mephenesin Mephenesin is an NMDA receptor antagonist, is a centrally acting muscle relaxant. Mephenesin Chemical Structure
  68. GC31036 MRZ 2-514 MRZ 2-514 is an antagonist of the strychnine-insensitive modulatory site of the NMDA receptor (glycineB), with Ki of 33 μM. MRZ 2-514 Chemical Structure
  69. GC33668 Naspm (1-Naphthylacetyl spermine) Naspm (1-Naphthylacetyl spermine) (1-Naphthyl acetyl spermine), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist. Naspm (1-Naphthylacetyl spermine) Chemical Structure
  70. GC13349 Naspm trihydrochloride Ca2+-permeable AMPA receptor antagonist Naspm trihydrochloride Chemical Structure
  71. GC14156 NBQX

    NBQX is a highly selective and competitive AMPA receptor antagonist.

     NBQX Chemical Structure
  72. GC30860 Neu2000 Neu2000 (Salfaprodil free base) is an NR2B-selective and uncompetitive antagonist of N-methyl-D-aspartate (NMDA). Neu2000 Chemical Structure
  73. GC17456 NMDA (N-Methyl-D-aspartic acid) NMDA (N-Methyl-D-aspartic acid) is a specific agonist forNMDA (N-Methyl-D-aspartic acid)receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. NMDA (N-Methyl-D-aspartic acid) Chemical Structure
  74. GC34352 NMDAR antagonist 1 NMDAR antagonist 1 is a potent and orally bioavailable NR2B-selective NMDAR antagonist. NMDAR antagonist 1 Chemical Structure
  75. GC64521 NMDAR/TRPM4-IN-2 free base NMDAR/TRPM4-IN-2 free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. NMDAR/TRPM4-IN-2 free base Chemical Structure
  76. GC64133 NS-102 NS-102 is a selective kainate (GluK2) receptor antagonist. NS-102 Chemical Structure
  77. GC33740 NT 13 (TPPT) NT 13 (TPPT) (TPPT) is a tetrapeptide having the amino acid sequence L-threonyl-L-prolyl-L-prolyl-L-threonine amide. NT 13 (TPPT) Chemical Structure
  78. GC30852 Org-26576 Org-26576 is a AMPA receptor positive allosteric modulator. Org-26576 Chemical Structure
  79. GC13779 Orphenadrine Citrate Antiparkinsonian and analgesic drug Orphenadrine Citrate Chemical Structure
  80. GC33701 Orphenadrine hydrochloride A muscarinic acetylcholine receptor antagonist Orphenadrine hydrochloride Chemical Structure
  81. GC16562 PEAQX NMDA antagonist PEAQX Chemical Structure
  82. GC36865 PEAQX tetrasodium hydrate PEAQX (NVP-AAM077) tetrasodium hydrate is a potent, selective and orally active NMDA antagonist, with IC50 values of 270 nM and 29600 nM for hNMDAR 1A/2B and hNMDAR 1A/2B, respectively. PEAQX tetrasodium hydrate Chemical Structure
  83. GC13007 PEPA Novel allosteric potentiator of AMPA receptor desensitization PEPA Chemical Structure
  84. GC36876 Perzinfotel Perzinfotel (EAA-090) is a potent, selective, and competitive NMDA receptor antagonist with neuroprotective effects. Perzinfotel Chemical Structure
  85. GC64929 Pesampator Pesampator (PF-04958242) is a potent and highly selective positive allosteric modulator of AMPA receptor (an AMPA potentiator) with an EC50 of 310 nM and a Ki of 170 nM. Pesampator Chemical Structure
  86. GC14492 PF 4778574 positive allosteric modulator of AMPA receptors PF 4778574 Chemical Structure
  87. GC12703 Philanthotoxin 74 Philanthotoxin 74 (PhTx 74) is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC50s of 263 and 296 nM, respectively. Philanthotoxin 74 Chemical Structure
  88. GC13469 Piracetam cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA) Piracetam Chemical Structure
  89. GC65954 Plazinemdor Plazinemdor is a N-methyl-D-aspartate(NMDA) receptor positive allosteric modulator. Plazinemdor can be uses in the research of psychiatric, neurological, and neurodevelopmental disorders, as well as diseases of the nervous system.. Plazinemdor Chemical Structure
  90. GC30946 Procyclidine hydrochloride ((±)-Procyclidine hydrochlorid) Procyclidine (Tricyclamol, (±)-Procyclidine) hydrochloride , an anticholinergic agent, is a muscarinic receptor antagonist that also has the properties of an N-methyl-D-aspartate (NMDA) antagonist. Procyclidine hydrochloride ((±)-Procyclidine hydrochlorid) Chemical Structure
  91. GC16776 QNZ 46 NR2C/NR2D-selective NMDA receptor antagonist QNZ 46 Chemical Structure
  92. GC14547 Quinolinic acid NMDA agonist Quinolinic acid Chemical Structure
  93. GC34753 Radiprodil

    An NMDA receptor antagonist

     Radiprodil Chemical Structure
  94. GC33492 Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate) Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate) (GLYX-13 Trifluoroacetate) is an NMDA receptor modulator with glycine-site partial agonist properties. Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate) Chemical Structure
  95. GC30835 Rislenemdaz (MK-0657) Rislenemdaz (MK-0657) (CERC-301) is an orally bioavailable and selective N-methyl-D-aspartate (NMDA) receptor subunit 2B (GluN2B) antagonist with Ki and IC 50 of 8.1 nM and 3.6 nM, respectively. Rislenemdaz (MK-0657) Chemical Structure
  96. GC19310 Ro 25-6981 Ro 25-6981 is a potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit. Ro 25-6981 Chemical Structure
  97. GC18410 Ro 25-6981 (maleate) Ro 25-6981 (maleate) is a potent, selective activity-dependent blocker of NMDA receptors containing the NR2B subunit (IC50s = 9 nM and 52 μM for cloned receptor subunit combinations NR1C/NR2B and NR1C/NR2A, respectively). Ro 25-6981 (maleate) Chemical Structure
  98. GC31039 RPR104632 RPR104632 is a specific antagonist of NMDA receptor, with potent neuroprotective properties. RPR104632 Chemical Structure
  99. GC13684 S 18986 positive allosteric modulator of AMPA receptors S 18986 Chemical Structure
  100. GC37612 SDZ 220-581 Ammonium salt SDZ 220-581 Ammonium salt is an orally active, potent, competitive NMDA receptor antagonist with pKi value of 7.7. SDZ 220-581 Ammonium salt Chemical Structure
  101. GC16986 SDZ 220-581 hydrochloride NMDA receptor antagonist SDZ 220-581 hydrochloride Chemical Structure

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