iGluR
iGluR (ionotropic glutamate receptor) is a ligand-gated ion channel that is activated by the neurotransmitter glutamate. iGluR are integral membrane proteins compose of four large subunits that form a central ion channel pore. Sequence similarity among all known glutamate receptor subunits, including the AMPA, kainate, NMDA, and δ receptors.
AMPA receptors are the main charge carriers during basal transmission, permitting influx of sodium ions to depolarise the postsynaptic membrane. NMDA receptors are blocked by magnesium ions and therefore only permit ion flux following prior depolarisation. This enables them to act as coincidence detectors for synaptic plasticity. Calcium influx through NMDA receptors leads to persistent modifications in the strength of synaptic transmission.
Targets for iGluR
Products for iGluR
- Cat.No. Product Name Information
- GC18033 γDGG γDGG is a competitive AMPA receptor blocker.
- GC11889 (S)-(-)-5-Fluorowillardiine AMPA receptor agonist
- GC34998 (S)-(-)-5-Fluorowillardiine hydrochloride (S)-(-)-5-Fluorowillardiine hydrochloride is a potent and specific AMPAR agonist.
- GC30212 (S)-Willardiine ((-)-Willardiine) (S)-Willardiine ((-)-Willardiine) is a potent agonist of AMPA/kainate receptors with EC50 of 44.8 uM.
- GC12863 1-BCP potentiator of AMPA-mediated responses
- GC33673 24-Hydroxycholesterol 24-Hydroxycholesterol is a natural sterol, which serves as a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factors LXR.
- GC31309 6-Methoxy-2-naphthoic acid (Naproxen impurity O) 6-Methoxy-2-naphthoic acid (Naproxen impurity O) is an NMDA receptor modulator extracted from patent WO 2012019106 A2.
- GC10781 7-Chlorokynurenic acid NMDA receptor glycine site antagonist
- GC11395 7-Chlorokynurenic acid sodium salt NMDA receptor antagonist acting at the glycine site
- GC68438 AMPA receptor modulator-3
- GC17695 Aniracetam Nootropic drug for senile dementia
- GC30911 Apimostinel (NRX-1074) Apimostinel (NRX-1074) (NRX-1074; AGN-241660) is an orally active NMDA receptor partial agonist.
- GC38497 ATPA
- GC33723 Becampanel (AMP 397) Becampanel (AMP 397) (AMP397) is the first competitive AMPA antagonist and an antiepileptic agent.
- GC64574 BZAD-01 BZAD-01 is a potent, selective and orally active inhibitor of NMDA NR2B subunit, with a Ki of 72 nM.
- GC18079 CFM-2 AMPA antagonist
- GC38493 CGP 37849
- GC14414 CIQ NMDA receptor potentiator
- GC13290 CMPDA positive allosteric modulator of AMPA receptors
- GC11799 CNQX AMPA/kainate receptor antagonist
- GC32553 CNS-5161 hydrochloride (CNS 5161A) CNS-5161 hydrochloride (CNS 5161A) is a novel NMDA ion-channel antagonist that interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the actions of glutamate.
- GC16899 Coluracetam Nootropic agent of the racetam family
-
GC70055
Crocetin meglumine
Crocetin (Transcrocetin) meglumine is extracted from saffron (Crocus sativus L.) and is a highly affinity NMDA receptor antagonist.
- GC14495 CX 546 AMPA receptor potentiator
- GC64244 CX 717 CX 717 is a positive allosteric modulator of AMPA receptor.
-
GC16315
D-AP5
A NMDA antagonist
- GC63881 DL-Phenylalanine-d5 hydrochloride
- GC32755 DNQX (FG 9041) DNQX (FG 9041) (FG 9041), a quinoxaline derivative, is a selective, potent competitive non-NMDA glutamate receptor antagonist (IC50s = 0.5, 2 and 40 μM for AMPA, kainate and NMDA receptors, respectively).
- GC35917 Dynorphin A (1-10) TFA
- GC35918 Dynorphin A 1-10 Dynorphin A 1-10 an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor.
- GC15343 Eliprodil NMDA receptor antagonist
- GC36027 Fanapanel hydrate Fanapanel hydrate (ZK200775 hydrate) is a highly selective AMPA/kainate antagonist with little activity against NMDA; have Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively.
- GC18223 Farampator Farampator is a positive allosteric modulator of AMPA receptors that has an EC50 value greater than 32 uM for evoking glutamate currents in isolated pyramidal neurons.
- GC10522 Felbamate antagonist at the NMDA-associated glycine binding site
- GC15363 Felbamate hydrate N-methyl-D-aspartate (NMDA) inhibitor
- GC36060 Flupirtine Flupirtine(D 9998) is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.
- GC11470 Flupirtine maleate NMDA receptor antagonist
- GC64245 Glycine-13C2
- GC64249 Glycine-15N
- GC14121 GLYX 13 GLYX 13 (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator that has characteristics of a glycine site partial agonist.
- GC31270 GNE 0723 GNE 0723 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 21 nM for GluN2A, 7.4 and 6.2 μM for GluN2C and GluN2D, respectively.
- GC31076 GNE 5729 GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively.
- GC31019 GV-196771A GV-196771A is the sodium salt form of GV196771, is an NMDA receptor antagonist.
- GC14842 GYKI 53655 hydrochloride AMPA and kainate receptor antagonist
- GC11715 Ibotenic acid NMDA and metabotropic glutamate receptor agonist
- GC30847 IC87201 An inhibitor of the nNOS-PSD-95 protein-protein interaction
- GC12521 Ifenprodil Tartrate NMDA receptor antagonist
- GC34638 JNJ-61432059 JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with a pIC50 of 9.7 for GluA1/γ-8.
- GC36411 Kynurenic acid sodium
- GC14810 L-701,324 NMDA receptor antagonist
- GC30788 L-Glutamic acid monosodium salt (Monosodium glutamate) L-Glutamic acid monosodium salt (Monosodium glutamate) acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).
- GC64352 L-Glutamic acid-15N
- GC65095 L-Glutamic acid-d5 L-Glutamic acid-d5 is the deuterium labeled L-Glutamic acid.
- GC66843 L-Homocysteic acid L-Homocysteic acid (L-HCA) is an endogenous excitatory amino acid that acts as a NMDA receptor agonist (EC50: 14 μM). L-Homocysteic acid is neurotoxic, and can be used in the research of neurological disorders.
- GC64148 L-Phenylalanine-15N
- GC65050 L-Phenylalanine-d2
- GC63982 L-Phenylalanine-d5
- GC64290 L-Phenylalanine-d8
-
GC11124
Lanicemine
voltage-dependent NMDA channel blocker
- GC36510 LY3130481 LY3130481 is an AMPA receptor antagonist that is dependent upon transmembrane AMPA receptor regulatory protein (TARP) γ-8, selective inhibits AMPA/TARP γ-8 with an IC50 of 65 nM.
- GC36515 LY450108 LY450108 is a potent AMPA receptor potentiator.
- GC13010 LY451395 LY451395 (LY451395) is a potent and highly selective potentiator of the AMPA receptors.
- GC30951 MDL 105519 MDL 105519 is a potent and selective antagonist of glycine binding to the NMDA receptor.
- GC14039 MDL-29951 Glycine antagonist of NMDA receptor activation
- GC10443 Meclofenoxate hydrochloride Drug for senile dementia and AD treatment
- GC10198 Memantine hydrochloride NMDA receptor antagonist
- GC30973 Mephenesin Mephenesin is an NMDA receptor antagonist, is a centrally acting muscle relaxant.
- GC31036 MRZ 2-514 MRZ 2-514 is an antagonist of the strychnine-insensitive modulatory site of the NMDA receptor (glycineB), with Ki of 33 μM.
- GC33668 Naspm (1-Naphthylacetyl spermine) Naspm (1-Naphthylacetyl spermine) (1-Naphthyl acetyl spermine), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.
- GC13349 Naspm trihydrochloride Ca2+-permeable AMPA receptor antagonist
-
GC14156
NBQX
NBQX is a highly selective and competitive AMPA receptor antagonist.
- GC30860 Neu2000 Neu2000 (Salfaprodil free base) is an NR2B-selective and uncompetitive antagonist of N-methyl-D-aspartate (NMDA).
- GC17456 NMDA (N-Methyl-D-aspartic acid) NMDA (N-Methyl-D-aspartic acid) is a specific agonist forNMDA (N-Methyl-D-aspartic acid)receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor.
- GC34352 NMDAR antagonist 1 NMDAR antagonist 1 is a potent and orally bioavailable NR2B-selective NMDAR antagonist.
- GC64521 NMDAR/TRPM4-IN-2 free base NMDAR/TRPM4-IN-2 free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor.
- GC64133 NS-102 NS-102 is a selective kainate (GluK2) receptor antagonist.
- GC33740 NT 13 (TPPT) NT 13 (TPPT) (TPPT) is a tetrapeptide having the amino acid sequence L-threonyl-L-prolyl-L-prolyl-L-threonine amide.
- GC30852 Org-26576 Org-26576 is a AMPA receptor positive allosteric modulator.
- GC13779 Orphenadrine Citrate Antiparkinsonian and analgesic drug
- GC33701 Orphenadrine hydrochloride A muscarinic acetylcholine receptor antagonist
- GC16562 PEAQX NMDA antagonist
- GC36865 PEAQX tetrasodium hydrate PEAQX (NVP-AAM077) tetrasodium hydrate is a potent, selective and orally active NMDA antagonist, with IC50 values of 270 nM and 29600 nM for hNMDAR 1A/2B and hNMDAR 1A/2B, respectively.
- GC13007 PEPA Novel allosteric potentiator of AMPA receptor desensitization
- GC36876 Perzinfotel Perzinfotel (EAA-090) is a potent, selective, and competitive NMDA receptor antagonist with neuroprotective effects.
- GC64929 Pesampator Pesampator (PF-04958242) is a potent and highly selective positive allosteric modulator of AMPA receptor (an AMPA potentiator) with an EC50 of 310 nM and a Ki of 170 nM.
- GC14492 PF 4778574 positive allosteric modulator of AMPA receptors
- GC12703 Philanthotoxin 74 Philanthotoxin 74 (PhTx 74) is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC50s of 263 and 296 nM, respectively.
- GC13469 Piracetam cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA)
- GC65954 Plazinemdor Plazinemdor is a N-methyl-D-aspartate(NMDA) receptor positive allosteric modulator. Plazinemdor can be uses in the research of psychiatric, neurological, and neurodevelopmental disorders, as well as diseases of the nervous system..
- GC30946 Procyclidine hydrochloride ((±)-Procyclidine hydrochlorid) Procyclidine (Tricyclamol, (±)-Procyclidine) hydrochloride , an anticholinergic agent, is a muscarinic receptor antagonist that also has the properties of an N-methyl-D-aspartate (NMDA) antagonist.
- GC16776 QNZ 46 NR2C/NR2D-selective NMDA receptor antagonist
- GC14547 Quinolinic acid NMDA agonist
-
GC34753
Radiprodil
An NMDA receptor antagonist
- GC33492 Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate) Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate) (GLYX-13 Trifluoroacetate) is an NMDA receptor modulator with glycine-site partial agonist properties.
- GC30835 Rislenemdaz (MK-0657) Rislenemdaz (MK-0657) (CERC-301) is an orally bioavailable and selective N-methyl-D-aspartate (NMDA) receptor subunit 2B (GluN2B) antagonist with Ki and IC 50 of 8.1 nM and 3.6 nM, respectively.
- GC19310 Ro 25-6981 Ro 25-6981 is a potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit.
- GC18410 Ro 25-6981 (maleate) Ro 25-6981 (maleate) is a potent, selective activity-dependent blocker of NMDA receptors containing the NR2B subunit (IC50s = 9 nM and 52 μM for cloned receptor subunit combinations NR1C/NR2B and NR1C/NR2A, respectively).
- GC31039 RPR104632 RPR104632 is a specific antagonist of NMDA receptor, with potent neuroprotective properties.
- GC13684 S 18986 positive allosteric modulator of AMPA receptors
- GC37612 SDZ 220-581 Ammonium salt SDZ 220-581 Ammonium salt is an orally active, potent, competitive NMDA receptor antagonist with pKi value of 7.7.