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Prostaglandin J2 Catalog No.GC18653

A PGD2 analog that inhibits platelet aggregation

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 60203-57-8 SDF Download SDF
Synonyms N/A
Chemical Name 11-oxo-15S-hydroxy-prosta-5Z,9,13E-trien-1-oic acid
Canonical SMILES CCCCC[[email protected]](O)/C=C/[[email protected]]([[email protected]@H](C/C=C\CCCC(O)=O)C=C1)C1=O
Formula C20H30O4 M.Wt 334.5
Solubility DMF: >100 mg/ml (from PGD2),DMSO: >50 mg/ml (from PGD2),Ethanol: >75 mg/ml (from PGD2),PBS pH 7.2: >2.7 mg/ml (from 15-deoxy-.DEL Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Prostaglandin J2 (PGJ2) is formed from PGD2 by the elimination of the C-9 hydroxyl group, a process which is accelerated by the presence of albumin. PGJ2 inhibits platelet aggregation with an IC50 of about 5-10 nM. PGJ2 has antimitotic and antiproliferative effects on a variety of cultured normal cells and tumor cell lines. However, this activity has been attributed to further metabolites of PGJ2 and not the parent compound itself.