Signaling Pathways

DPTIP is an inhibitor of neutral sphingomyelinase 2 (nSMase2; IC50 = 30 nM).

SJB2-043 analog is an inhibitor of OTUB1 and USP8 (IC50s = 0.17 and 0.28 nM, respectively) and a derivative of the USP1/UAF1 complex and SARS-CoV-2 PLPro inhibitor SJB2-043.

MT-1207 is an orally active and selective adrenergic α1 and 5-HT2A receptor antagonist. MT-1207 shows IC50<0.1 nM, 0.15 nM, 1.40 nM and 0.27 nM for α1A, α1B, α1D and 5-HT2A, respectively.

PKN3 inhibitor compound 16 is an inhibitor of serine/threonine protein kinase N3 (IC50 = 14 nM).

WYneN is a chemoselective probe for the detection of sulfenylated proteins in live cells.

WyneO is a probe for the detection of sulfenylated proteins.

N,N′-Diferuloylputrescine is a polyamine that has been found in Z. mays and has diverse biological activities.

1-Octadecyl-2-hydroxy-sn-glycero-3-phosphate (1-Octadecyl LPA) is a LPA analog containing stearyl alcohol at the sn-1 position.

4-hydroxy Nonenal Glutathione-d3 (4-HNE-GSH-d3) is intended for use as an internal standard for the quantification of 4-HNE-GSH by GC- or LC-MS.

PTX80 is an antagonist of p62 (IC50 = 31.18 nM for the human receptor).

BPN-01 is a fluorescent probe for cancer cells.

D-Val-Leu-Lys-pNA is a colorimetric substrate for plasmin.

UCM-05194 is an agonist of lysophosphatidic acid receptor 1 (LPA1).

N-Lithocholyl-L-leucine is a bile acid conjugate composed of lithocholic acid and L-leucine.

Debio 0123 is an inhibitor of the checkpoint kinase WEE1 (IC50 = 0.8 nM).

GPX4 inhibitor 17 is a ferrocene-containing inhibitor of glutathione peroxidase 4 (GPX4) and an inducer of ferroptosis.

HPG1860 is a farnesoid X receptor (FXR) agonist.

MCL0020 is a melanocortin receptor 4 (MC4R) antagonist.

JQKD82 is a prodrug form of KDM5-C49, an inhibitor of Jumonji AT-rich interactive domain 1A (JARID1A), also known as lysine-specific demethylase 5A (KDM5A).

NO-Rosa5 is a photocontrollable nitric oxide (NO) donor for in cellulo and ex vivo use.

SGC0946 is an inhibitor of the non-SET domain-containing methyltransferase DOT1L (IC50 = 0.3 nM).

9(10)-Nitrooleate is a mixture of the nitroalkene endogenous lipid signaling molecules 9-nitrooleate.

H1L1A1B3 is an ionizable cationic lipid that has been used in combination with other lipids in the formation of LNPs for the delivery of circular RNA (circRNA) in vitro and in vivo.

O12-D3-I3 is an ionizable cationic lipid (pKa = 6.39) that has been used in the generation of lipid nanoparticles (LNPs) for siRNA delivery in vitro and in vivo.