Signaling Pathways

GLP-1 (7-13) (human, mouse, rat, bovine) (trifluoroacetate salt) is a peptide fragment of the endogenous incretin hormone GLP-1.

1-Palmitoyl-2-13(S)-HODE-sn-glycero-3-PC is an oxidized phospholipid that contains palmitic acid and 13(S)-HODE at the sn-1 and sn-2 positions, respectively.

CellFluor GST is a cell-permeable quenched fluorescent probe for the detection of pan-glutathione S-transferase activity in adherent or suspension cells, cell or tissue lysates, or purified enzyme preparations.

RMC-6236 is a reversible, GTP-binding RAS (ON) multi-selective inhibitor.

Lipid N2-3L is an ionizable cationic lipid (pKa = 8.99) that has been used in the generation of supramolecular lipid nanoparticles (SMLNPs) encapsulating mRNA for use in vitro and in vivo.

AIZin2 is a conditional labeling compound for zinc-binding proteins that contains a zinc-coordinating tridentate dipicolylamine group, an electrophile-reactive acyl imidazole moiety, and fluorescein diacetate.

6,6′-Trehalose dioleate (6,6′-TDO) is a glycolipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.

YHS-12 is an ionizable cationic lipid (pKa = 6.506) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA in vitro and in vivo.

1,2,3-Trioleoyl glycerol-d5 is intended for use as an internal standard for the quantification of 1,2,3-trioleoyl glycerol by GC- or LC-MS.

119-23 is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.

C9-200 is an ionizable cationic lipid that has been used in the formation of lipid nanoparticles (LNPs).

PKG inhibitor is a specific cGMP-dependent PKG inhibitor (Ki = 86 μM).

Glucagon-like peptide 1 (GLP-1) (7-15) is a peptide fragment of the endogenous incretin hormone GLP-1.

4-O10b1 is an ionizable cationic lipid (pKa = 5.148) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA in vitro and in vivo.

Glucagon-like peptide 1 (GLP-1) (28-36) amide is a peptide and an active metabolite of the endogenous GLP-1R agonist GLP-1 (7-36) amide.

PtdIns-(4,5)-P2 (1,2-dipalmitoyl)-d62 (sodium salt) is intended for use as an internal standard for the quantification of PtdIns-(4,5)-P2 (1,2-dipalmitoyl) (sodium salt) by GC- or LC-mass spectrometry.

CTX-1211 is a peptide agonist of melanocortin receptors.

Glucagon-like peptide 1 (GLP-1) (7-17) is a peptide fragment of the endogenous incretin hormone GLP-1 .

KISS1-305 is a peptide agonist of the kisspeptin receptor.

Ac-(D-Arg)-CEH-(D-Phe)-RWC-NH2 is a cyclic peptide and an agonist of melanocortin receptor 4 (MC4R).

TCMCB07 is a peptide antagonist of melanocortin receptor 1 (MC1R), MC3R, MC4R, and MC5R (IC50s = 19.5, 0.59, 13.58, and 8.07 nM, respectively, for the human receptors).

HS-024 is a cyclic peptide antagonist of melanocortin receptor 4 (MC4R; Ki = 0.29 nM).

MSG606 is a peptide antagonist of melanocortin receptor 1 (MC1R; IC50 = 17 nM for the human receptor) and a derivative of γ-melanocyte-stimulating hormone (γ-MSH).

Neuropeptide EI (NEI) is an endogenous peptide fragment of rat prepro-melanin concentrating hormone (MCH) that is involved in hormone release, grooming behavior, and motor activity.