ADC Linker
Antibody-drug conjugates (ADCs) consist of a desirable monoclonal antibody, an active cytotoxic drug and an appropriate linker. An appropriate linker between the antibody and the cytotoxic drug provides a specific bridge, and thus helps the antibody to selectively deliver the cytotoxic drug to tumor cells and accurately releases the cytotoxic drug at tumor sites. In addition to conjugation, the linkers maintain ADCs’ stability during the preparation and storage stages of the ADCs and during the systemic circulation period.
The ADCs currently undergoing clinical evaluation contain linkers are mostly classified into two categories: cleavable and noncleavable. Cleavable linkers rely on processes inside the cell to liberate the toxin, such as reduction in the cytoplasm, exposure to acidic conditions in the lysosome, or cleavage by specific proteases within the cell. Noncleavable linkers require proteolytic degradation of the antibody portion of the ADC for release of the cytotoxic molecule, which will retain the linker and the amino acid by which it was attached to the antibody.
The selection of linker is target dependent, based on the knowledge of the internalization and degradation of the antibody-target antigen complex, and a preclinical in vitro and in vivo activity comparison of conjugates. Moreover, the choice of a linker is also influenced by which cytotoxin is used, as each molecule has different chemical constraints, and frequently the drug structure lends itself to a specific linker.
Targets for ADC Linker
Products for ADC Linker
- Cat.No. Product Name Information
- GC63919 Mal-PEG6-NHS ester Mal-PEG6-NHS ester is a nonclaevable ADC linker containing a Maleimide group, 6-unit PEG and a NHS ester.
- GC67813 Mal-PEG8-Val-Ala-PABC
- GC67609 Mal-Ph-CONH-PEG4-NHS ester Mal-Ph-CONH-PEG4-NHS ester is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66826 Mal-Sulfo-DBCO Mal-Sulfo-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
-
GC60235
Maleimide-DOTA
Maleimide-DOTA is a non-degradable ADC linker used in antibody drug conjugate (ADC) synthesis[1].
- GC60236 Maleimido-tri(ethylene glycol)-propionic acid Maleimido-tri(ethylene glycol)-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Maleimido-tri(ethylene glycol)-propionic acid is used for the preparation of neolymphostin-based ADC precursors for site-specific cysteine mutant trastuzumab-A114C conjugation. Maleimido-tri(ethylene glycol)-propionic acid also can be used as a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- GC44115 Maleimidoacetic Acid N-hydroxysuccinimide ester Maleimidoacetic Acid N-hydroxysuccinimide ester is a nonclaevable heterobifunctional crosslinker with NHS ester and maleimide groups that allows covalent conjugation of amine- and sulfhydryl-containing molecules.
- GC66770 MC(C5)-Val-Cit MC(C5)-Val-Cit is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66194 Mc-?Val-?Ala-?PAB Mc-Val-Ala-PAB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC38926 MC-Gly-Gly-Phe MC-Gly-Gly-Phe is a cleavable linker used for antibody-drug conjugates (ADC).
- GC62264 MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC64037 Mc-Gly-Gly-Phe-Gly-PAB-OH TFA Mc-Gly-Gly-Phe-Gly-PAB-OH (Mc-GGFG-PAB-OH) TFA is a cleavable ADC linker used for antibody-drug conjugates (ADCs).
- GC38069 MC-PEG2-C2-NHS ester MC-PEG2-C2-NHS ester is a nonclaevable 2-unit PEG linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC39680 MC-Val-Ala-OH MC-Val-Ala-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC36565 MC-Val-Cit-PAB A peptide linker molecule
- GC61034 Mc-Val-Cit-PAB-Cl Mc-Val-Cit-PAB-Cl is a cleavable ADC linker. Mc-Val-Cit-PAB-Cl can be used to conjugate MMAE and antibody to form antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE with IC50s of 3.3 and 0.95 nM for BJAB and WSU cell lines in cytotoxicity assay).
- GC64087 MC-Val-Cit-PAB-NH-C2-NH-Boc MC-Val-Cit-PAB-NH-C2-NH-Boc is a cathepsin cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC17032 Mc-Val-Cit-PABC-PNP Cathepsin cleavable ADC peptide linker
- GC63722 MC-VC-PAB-Azide
- GC64470 MCC MCC is non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as MCC-DM1.
- GC67337 Me-triacetyl-β-D-glucopyranuronate-Ph-ald-NO2 Me-triacetyl-β-D-glucopyranuronate-Ph-ald-NO2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66629 Me-triacetyl-β-D-glucopyranuronate-Ph-CH2OH-Fmoc Me-triacetyl-β-D-glucopyranuronate-Ph-CH2OH-Fmoc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC64158 Methyl 1-Boc-azetidine-3-carboxylate Methyl 1-Boc-azetidine-3-carboxylate is a non-cleavable?ADC linker?used in the synthesis of antibody-drug conjugates (ADCs). Methyl 1-Boc-azetidine-3-carboxylate is also a alkyl chain-based PROTAC linker?that can be used in the synthesis of PROTACs[1
- GC66215 Methyl 1-Cbz-azetidine-3-carboxylate Methyl 1-Cbz-azetidine-3-carboxylate is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl 1-Cbz-azetidine-3-carboxylate is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1
- GC64174 Methyl azetidine-3-carboxylate hydrochloride Methyl azetidine-3-carboxylate hydrochloride is a non-cleavable?ADC linker?used in the synthesis of antibody-drug conjugates (ADCs). Methyl azetidine-3-carboxylate hydrochloride is also a alkyl chain-based PROTAC linker?that can be used in the synthesis of PROTACs<
- GC64509 MethylCBI-azaindole-benzamide-MOM-Boc-ethylenediamine-D MethylCBI-azaindole-benzamide-MOM-Boc-ethylenediamine-D is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66957 Methyltetrazine-DBCO Methyltetrazine-DBCO is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC61101 N-(5-Hydroxypentyl)maleimide N-(5-Hydroxypentyl)maleimide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as Gemcitabine-O-Si(di-iso)-O-Mc ).
- GC67509 N-(Iodoacetamido)-Doxorubicin N-(Iodoacetamido)-Doxorubicin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC63812 N-Boc-cis-4-Hydroxy-D-proline N-Boc-cis-4-Hydroxy-D-proline is a non-cleavable?ADC linker?used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-Hydroxy-D-proline is also a alkyl chain-based PROTAC linker?that can be used in the synth
- GC64045 N-Boc-cis-4-hydroxy-D-proline methyl ester N-Boc-cis-4-hydroxy-D-proline methyl ester is a non-cleavable?ADC linker?used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-D-proline methyl ester is also a alkyl chain-based PROTAC linker?that can be used in the synthesis of PROTACs[1
- GC64046 N-Boc-cis-4-hydroxy-L-proline N-Boc-cis-4-hydroxy-L-proline is a non-cleavable?ADC linker?used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-L-proline is also a alkyl chain-based PROTAC linker?that can be used in the synthesis of PROTACs[2
- GC61112 N-Boc-diethanolamine N-Boc-diethanolamine is an Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-diethanolamine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66708 N-Boc-N-bis(PEG2-OH) N-Boc-N-bis(PEG2-OH) is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-N-bis(PEG2-OH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC67164 N-Boc-N-bis(PEG4-OH) N-Boc-N-bis(PEG4-OH) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-N-bis(PEG4-OH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC62704 N-Boc-PEG2-bromide N-Boc-PEG2-bromide is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG2-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC61113 N-Boc-PEG3-bromide N-Boc-PEG3-bromide is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG3-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC61616 N-Boc-PEG4-bromide N-Boc-PEG4-bromide is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG4-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC65833 N-Boc-PEG5-bromide N-Boc-PEG5-bromide is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG5-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC64355 N-Boc-PEG6-alcohol N-Boc-PEG6-alcohol is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG6-alcohol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66155 N-Boc-PEG7-alcohol N-Boc-PEG7-alcohol is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG7-alcohol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66730 N-Boc-PEG9-alcohol N-Boc-PEG9-alcohol is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG9-alcohol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC19519 N-butyryl-L-Homoserine lactone N-butyryl-L-Homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC44398 N-Hydroxysulfosuccinimide (sodium salt) N-Hydroxysulfosuccinimide (sodium) is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC39413 N-Succinimidyloxycarbonylpropyl methanethiosulfonate N-Succinimidyloxycarbonylpropyl methanethiosulfonate is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC64094 N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline is a non-cleavable?ADC linker?used in the synthesis of antibody-drug conjugates (ADCs). N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline is also a alkyl chain-based PROTAC linker?that can be used in the synthesis of PROTACs.
-
GC69524
N1-Azido-spermine trihydrochloride
N1-Azido-spermine [Spermine(HHHN3)] trihydrochloride is a click chemistry reagent containing azide.
- GC38335 N3-C2-NHS ester N3-C2-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC38339 N3-C3-NHS ester N3-C3-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC38341 N3-C4-NHS ester N3-C4-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC38340 N3-C5-NHS ester N3-C5-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC61856 N3-PEG2-C2-NHS ester N3-PEG2-C2-NHS ester is a nonclaevable 2-unit PEG linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66828 N3-PEG2-C2-PFP ester N3-PEG2-C2-PFP ester is a nonclaevable 2-unit PEG linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC38455 N3-PEG3-C2-NHS ester N3-PEG3-C2-NHS ester is a nonclaevable 3-unit PEG linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66829 N3-PEG3-C2-PFP ester N3-PEG3-C2-PFP ester is a nonclaevable 3-unit PEG linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC65822 N3-PEG3-CH2CH2-Boc N3-PEG3-CH2CH2-Boc is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N3-PEG3-CH2CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
- GC64177 N3-PEG3-CH2CH2COOH N3-PEG3-CH2CH2COOH a PEG-based PROTAC linker can be used in the synthesis of BI-3663, BI-4216 and BI-0319.
- GC61854 N3-PEG4-C2-NHS ester N3-PEG4-C2-NHS ester is a nonclaevable 4-unit PEG linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC38041 N3-PEG4-C2-Pfp ester N3-PEG4-C2-Pfp ester is a nonclaevable 4-unit PEG linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC67577 N3-PEG5-aldehyde N3-PEG5-aldehyde is a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC38601 N3-Ph-NHS ester N3-Ph-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66235 NH-bis(C1-Boc) NH-bis(C1-Boc)is a uncleavable linker used for antibody-drug conjugates (ADC).
- GC67456 NH-bis-PEG2 NH-bis-PEG2 is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). NH-bis-PEG2 is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- GC61128 NH2-PEG2-C2-Boc NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC61407 NH2-PEG5-OH NH2-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG5-OH is also a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC64153 NH2-PEG6-Boc NH2-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG6-Boc is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC62171 NH2-PEG6-CH2CH2COOH NH2-PEG6-CH2CH2COOH is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). NH2-PEG6-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- GC38076 NHPI-PEG2-C2-NHS ester NHPI-PEG2-C2-NHS ester is a nonclaevable 2-unit PEG linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC38071 NHPI-PEG2-C2-Pfp ester NHPI-PEG2-C2-Pfp ester is a nonclaevable 2-unit PEG linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC38078 NHPI-PEG3-C2-NHS ester NHPI-PEG3-C2-NHS ester is a nonclaevable 3-unit PEG linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC38077 NHPI-PEG3-C2-Pfp ester NHPI-PEG3-C2-Pfp ester is a nonclaevable 3-unit PEG linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC38461 NHPI-PEG4-C2-NHS ester NHPI-PEG4-C2-NHS ester, example 40 (WO2014185985A1), is used as a linker for antibody-drug conjugates (ADC).
- GC38018 NHPI-PEG4-C2-Pfp ester NHPI-PEG4-C2-Pfp ester is used as a linker for antibody-drug conjugates (ADC).
- GC61131 NHS-PEG2-SS-PEG2-NHS NHS-PEG2-SS-PEG2-NHS is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC64954 NHS-SS-Ph NHS-SS-Ph is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC67189 NO2-SPP NO2-SPP is a cleavable linker that is used for making antibody-drug conjugate (ADC).
- GC38021 NO2-SPP-sulfo-Me NO2-SPP-sulfo-Me is a cleavable linker that is used for making antibody-drug conjugate (ADC).
- GC67687 OH-Glu-Val-Cit-PAB-MMAE
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GC69629
OPSS-PEG36-acid
OPSS-PEG36-acid is a cleavable ADC linker containing 36 units of PEG, which can be used to synthesize antibody-drug conjugates (ADCs).
- GC65427 PAB-Val-Lys-Boc PAB-Val-Lys-Boc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) for stimulating an immune response.
- GC66267 PC Alkyne-PEG4-NHS ester PC Alkyne-PEG4-NHS ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC67654 PC Biotin-PEG3-alkyne PC Biotin-PEG3-alkyne is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66524 PC Biotin-PEG3-azide PC Biotin-PEG3-azide is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC67655 PC Biotin-PEG3-NHS ester PC Biotin-PEG3-NHS ester is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66961 PC Mal-NHS carbonate ester PC Mal-NHS carbonate ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC66852 PC SPDP-NHS carbonate ester PC SPDP-NHS carbonate ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC67640 PC-Biotin-PEG4-PEG3-azide PC-Biotin-PEG4-PEG3-azide is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC38442 PDB-Pfp PDB-Pfp is a cleavable ADC linker?used in the synthesis of antibody-drug conjugates (ADCs).
- GC38345 PDdB-Pfp PDdB-Pfp is a cleavable ADC linker used for the agents that target for the extracellular loop 1 (ECL1) of?TM4SF1?(transmembrane 4 L6 family member 1).
- GC38070 PDdEC-NB PDdEC-NB is a disulfide cleavable linker used for the antibody-drug conjugate?(ADC).
- GC38343 PDEC-NB PDEC-NB is a disulfide cleavable linker used for the antibody-drug conjugate?(ADC).
-
GC38632
PDP-C1-Ph-Val-Cit
PDP-C1-Ph-Val-Cit is a cleavable ADC linker used for antibody-drug conjugates (ADCs).
- GC38074 PDP-Pfp PDP-Pfp is a reducible ADC linker used for the agents that target for the extracellular loop 1 (ECL1) of TM4SF1 (transmembrane 4 L6 family member 1).
- GC67324 PEG12-Tos Tos-PEG12 is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). PEG12-Tos is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- GC38035 PEG4-SPDP PEG4-SPDP is a cleavable ADC linker used for the antibody-drug conjugates (ADCs).
- GC38124 Phe-Lys(Fmoc)-PAB Phe-Lys(Fmoc)-PAB is a cathepsin cleavable ADC linker used for the antibody-drug conjugates (ADCs).
- GC38121 Phe-Lys(Trt)-PAB Phe-Lys(Trt)-PAB is a cathepsin cleavable ADC linker used for the antibody-drug conjugates (ADCs).
- GC38348 PPC-NB PPC-NB is a glutathione cleavable linker used for the antibody-drug conjugate (ADC).
- GC39422 PPC-NHS ester PPC-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- GC38458 Propargyl-C1-NHS ester Propargyl-C1-NHS ester is a nonclaevable linker for antibody-drug-conjugation (ADC).