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Home >> Signaling Pathways >> Neuroscience >> AChE

AChE

AChE, also know as acetylcholinesterase, is a hydrolase that hydrolyzes the neurotransmitter acetylcholine.

Products for  AChE

  1. Cat.No. Product Name Information
  2. GN10155 (+)- Corydaline

    (+)-Corydaline, D-Corydaline, NSC 406036

     (+)- Corydaline Chemical Structure
  3. GN10654 (+)-Corynoline

    (+)-Corynoline, 13-methyl-Chelidonine, CRL, (d)-Corynoline

     (+)-Corynoline Chemical Structure
  4. GC34947 (-)-Corynoxidine (-)-Corynoxidine is an acetylcholinesterase inhibitor with an IC50 value of 89.0 μM, isolated from the aerial parts of Corydalis speciosa. (-)-Corynoxidine Chemical Structure
  5. GC14400 (-)-Huperzine A

    Hup A, (-)-Selagine

     AChE inhibitor (-)-Huperzine A Chemical Structure
  6. GC48551 (-)-Physostigmine (salicylate)

    Physostigmine

     An alkaloid and cholinergic agent (-)-Physostigmine (salicylate) Chemical Structure
  7. GC34993 (R)-Rivastigmine D6 tartrate (R)-Rivastigmine D6 tartrate Chemical Structure
  8. GC11965 (±)-Huperzine A

    Hup A, (-)-Selagine

     A neuroprotective AChE inhibitor (±)-Huperzine A Chemical Structure
  9. GC41774 1,2,3-Trimyristoyl-rac-glycerol

    Glycerol Tritetradecanoate, Myristic Acid Triglyceride, NSC 4062, TG(14:0/14:0/14:0), Tritetradecanoyl Glycerol

     1,2,3-Trimyristoyl-rac-glycerol, an active molluscicidal component ofMyristica fragransHoutt, significantly inhibits acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue ofLymnaea acuminata. 1,2,3-Trimyristoyl-rac-glycerol Chemical Structure
  10. GC38698 1-Naphthyl acetate 1-Naphthyl acetate is an attractive chromogenic substrate for the detection of erythrocyte acetylcholinesterase (AChE) activity. 1-Naphthyl acetate Chemical Structure
  11. GC11606 4-Methylbenzylidene camphor

    Enzacamene|Eusolex 6300|4-MBC|Neo Heliopan MBC|Parsol 500|Uvinul MBC 95

     ultraviolet light blocker used in cosmetics and sunscreen preparations that also has estrogenic activities. 4-Methylbenzylidene camphor Chemical Structure
  12. GC15203 Acephate

    RE 12420

     Anticholinesterase insecticide Acephate Chemical Structure
  13. GC35236 Acetylshikonin Acetylshikonin, derived from the root of Lithospermum erythrorhizon, has anti-cancer and antiinflammation activity. Acetylshikonin Chemical Structure
  14. GC62827 Acotiamide D6

    Z-338-d6 free base; YM443-d6 free base

     Acotiamide D6 Chemical Structure
  15. GC38732 Acotiamide monohydrochloride trihydrate Acotiamide monohydrochloride trihydrate is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with IC50 of 1.79 μM. Acotiamide monohydrochloride trihydrate Chemical Structure
  16. GC35272 Ajmalicine

    (-)-Ajmalicine, NSC 72133, NSC 95087, Raubasine

     A terpenoid indole alkaloid Ajmalicine Chemical Structure
  17. GC35279 Aldicarb sulfone Aldicarb sulfone(Temik sulfone) is a carbamate insecticide; is a cholinesterase inhibitor which prevents the breakdown of acetylcholine in the synapse. Aldicarb sulfone Chemical Structure
  18. GC16974 Ambenonium dichloride Ambenonium (WIN 8077) chloride is an orally active and reversible inhibitor of Acetyicholinesterase (AChE) with high affinity. Ambenonium dichloride Chemical Structure
  19. GC15438 Asoxime (chloride)

    HI-6

     Asoxime (chloride) (HI-6) is an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α7 nAChR. Asoxime (chloride) Chemical Structure
  20. GC31193 Benactyzine hydrochloride Benactyzine hydrochloride is a butyrylcholinesterase (BChE) inhibitor with a Ki of 0.010 mM. Benactyzine hydrochloride Chemical Structure
  21. GC15628 bis(7)-Tacrine

    1,7-N-heptylene-bis-9,9'-amino-1,2,3,4-tetrahydro-acridine

     bis(7)-Tacrine is a dimeric AChE inhibitor derived from tacrine. bis(7)-Tacrine Chemical Structure
  22. GC35564 BuChE-IN-TM-10

    TM-10

     BuChE-IN-TM-10 (TM-10) is a potent butyrylcholinesterase (BuChE) inhibitor, with an IC50 of 8.9 nM. BuChE-IN-TM-10 Chemical Structure
  23. GC60108 Chlorpyrifos Chlorpyrifos is a neurotoxic insecticide. Chlorpyrifos Chemical Structure
  24. GC39836 Coumaran Coumaran (2,3-Dihydrobenzofuran) is an acetylcholinesterase (AChE) inhibitor isolated from leaves of L. Coumaran Chemical Structure
  25. GC43336 Cyanidin 3-O-β-D-Galactopyranoside (chloride)

    Cyanidin 3-Galactoside, 3-β-Galactosidylcyanidin, Idaein

     Cyanidin 3-O-β-D-Galactopyranoside (chloride) (Ideain chloride) is a component from extract peel of hawthorn fruit (EPHF) with the value of 179.4 mg/g. Cyanidin 3-O-β-D-Galactopyranoside (chloride) Chemical Structure
  26. GC38625 Dehydronuciferine Dehydronuciferine is isolated from the leaves of Nelumbo nucifera Gaertn, a acetylcholinesterase (AChE) inhibitor with an IC50 of 25 μg/mL. Dehydronuciferine Chemical Structure
  27. GC31190 Demecarium Bromide (BC-48) Demecarium Bromide (BC-48) (BC-48) is a potent cholinesterase inhibitor, with an apparent affinity (Kiapp) of 0.15 μM. Demecarium Bromide (BC-48) Chemical Structure
  28. GC60774 Dihydro Donepezil Dihydro Donepezil (Dihydro E2020) is a metabolite of Donepezil. Dihydro Donepezil Chemical Structure
  29. GC63620 Dihydrowithaferin A Dihydrowithaferin A (2, 3-dihydrowithaferin A) is a withanolide isolated from Withania somnifera. Dihydrowithaferin A is active against acetylcholinesterase (AChE). Dihydrowithaferin A Chemical Structure
  30. GC30810 Donepezil (E2020)

    Donepezil (E2020) is an acetylcholinesterase (AChE) inhibitor with an IC50 of 6.7nM.

     Donepezil (E2020) Chemical Structure
  31. GC14490 Donepezil HCl Donepezil HCl (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity. Donepezil HCl Chemical Structure
  32. GC63334 Donepezil-d7 hydrochloride

    E2020-d7

     Donepezil-d7 hydrochloride Chemical Structure
  33. GC30908 Drofenine hydrochloride (Hexahydroadiphenine hydrochloride) Drofenine hydrochloride (Hexahydroadiphenine hydrochloride) is a potent competitive inhibitor of BChE, and the ki values of Drofenine is calculated to be 3 uM. Drofenine hydrochloride (Hexahydroadiphenine hydrochloride) Chemical Structure
  34. GC17705 Edrophonium (chloride)

    Enlon®,Tensilon®

     acetylcholinesterase (AChE) inhibitor Edrophonium (chloride) Chemical Structure
  35. GN10716 Epiberberine Epiberberine Chemical Structure
  36. GC35996 Epiberberine chloride Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine chloride Chemical Structure
  37. GC60164 Fenitrothion Fenitrothion, one of the most widely used organophosphorus pesticides, is a cholinesterase inhibiting insecticide/acaricid. Fenitrothion Chemical Structure
  38. GC16573 Galanthamine

    Galanthamine, NSC 100058

     An alkaloid with AChE inhibitory and nAChR potentiating activities Galanthamine Chemical Structure
  39. GC36103 Galanthamine hydrobromide Galanthamine hydrobromide Chemical Structure
  40. GC36104 Galanthaminone Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments. Galanthaminone Chemical Structure
  41. GC13474 Garcinol

    Camboginol

    Garcinol is an nonspecificity inhibitor of the histone acetyltransferases (HATs) p300 and PCAF .IC50 values are 7μM and 5μM respectively.

     Garcinol Chemical Structure
  42. GC15832 GSK 264220A endothelial lipase and lipoprotein lipase inhibitor GSK 264220A Chemical Structure
  43. GC64193 Hemicholinium 3

    Hemicholinium 3 is a competitive inhibitor of the high affinity choline transporter (HACU) with a Ki value of 25 nM.

     Hemicholinium 3 Chemical Structure
  44. GC38793 Huperzine B

    Fordimine, (-)-Huperzine B

     Huperzine B is a Lycopodium alkaloid isolated from Huperzia serrata and a highly selective acetylcholinesterase (AChE) inhibitor. Huperzine B Chemical Structure
  45. GC60913 Huperzine C Huperzine C is an alkaloid isolated from Huperzia serrate. Huperzine C Chemical Structure
  46. GC15604 Hydroxytacrine (maleate)

    HP 029,1-Hydroxytacrine,P 83-6029A,Velnacrine

     anticholinesterase activity Hydroxytacrine (maleate) Chemical Structure
  47. GN10437 Imperatorin

    Marmelosin, NSC 402949

     Imperatorin Chemical Structure
  48. GC36334 Isoeugenol acetate Isoeugenol acetate (Acetyl isoeugenol), an essential oil constituent of nutmeg, clove, and cinnamon, shows excellent inhibitory effects against some metabolic enzymes such as acetylcholinesterase (AChE) enzymes (IC50=77 nM; Ki=16 nM), α-glycosidase (IC50=19.25 nM; Ki=21 nM), and α-amylase (IC50=411.5 nM). Isoeugenol acetate Chemical Structure
  49. GN10352 Isoimperatorin Isoimperatorin Chemical Structure
  50. GC36336 Isomerazin

    7-methoxy-8-(3-methyl-2-oxobutyl) Coumarin

     Isomerazin is a coumarin isolated from Poncirus trifoliate Raf. Isomerazin Chemical Structure
  51. GC36340 Isorosmanol Isorosmanol is an abietane-type diterpene isolated from the leaves of sage, with antioxidant, neuroprotective and neurotrophic effects. Isorosmanol Chemical Structure
  52. GC15895 Itopride hydrochloride AChE inhibitor Itopride hydrochloride Chemical Structure
  53. GC38433 Jatrorrhizine Jatrorrhizine is an alkaloid isolated from?Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities. Jatrorrhizine Chemical Structure
  54. GC43926 Jatrorrhizine (chloride)

    NSC 645313

     Jatrorrhizine is an alkaloid that has been found in the Chinese herb C. Jatrorrhizine (chloride) Chemical Structure
  55. GC60957 Jatrorrhizine hydroxide Jatrorrhizine?hydroxide is an alkaloid isolated from?Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities. Jatrorrhizine hydroxide Chemical Structure
  56. GC17304 JW 642 monoacylglycerol lipase (MAGL) inhibitor JW 642 Chemical Structure
  57. GC17385 KML 29 KML 29 is reported to display IC50 values of 43, 15, and 5.9 nM toward rat, mouse, and human monoacylglycerol lipase (MAGL), respectively. KML 29 Chemical Structure
  58. GC39052 Leptomerine Leptomerine, an alkaloid from stems of Esenbeckia leiocarpa Engl. Leptomerine Chemical Structure
  59. GC61017 Lycoramine hydrobromide Lycoramine hydrobromide, a dihydro-derivative of galanthamine, is isolated from Lycoris radiate. Lycoramine hydrobromide Chemical Structure
  60. GC18891 Malathion

    NSC 6524

    An organophosphate insecticide

     Malathion Chemical Structure
  61. GC32194 Metrifonate (Trichlorfon) Metrifonate (Trichlorfon) Chemical Structure
  62. GC30446 MHP 133 MHP 133 is a drug with multiple CNS targets, and inhibits acetylcholinesterase (AChE) with Ki of 69 μM; also active against muscarinic M1 and M2 receptors, serotonin 5HT4 receptors, and imidazole I2 receptors. MHP 133 Chemical Structure
  63. GC40847 Neoeriocitrin

    Eriodictyol 7-O-neohesperidoside

     Neoeriocitrin is a highly potent inhibitor of lactate dehydrogenase A, with an IC50 value of 11.198 ± 0.90µM. Neoeriocitrin Chemical Structure
  64. GC30290 Neostigmine methyl sulfate

    NSC 93753

     A reversible acetylcholinesterase inhibitor Neostigmine methyl sulfate Chemical Structure
  65. GC61848 O-Desmethyl Galanthamine

    Sanguinine

     O-Desmethyl Galanthamine (Sanguinine) is galanthamine-type alkaloid. O-Desmethyl Galanthamine Chemical Structure
  66. GC63305 Obidoxime dichloride

    Toxogonin

     Obidoxime dichloride is a non-full spectrum oxime agent and can be used as an antidote for organophosphate nerve agent poisoning. Obidoxime dichloride Chemical Structure
  67. GC63134 P11149 P11149 is a competitive, BBB-penetarated weakly, orally active and selective inhibitor of AChE. P11149 Chemical Structure
  68. GC14163 PE 154 human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitor PE 154 Chemical Structure
  69. GC61453 Penconazole Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole Chemical Structure
  70. GC13783 Phenserine

    (-)-Eseroline phenylcarbamate, (-)-N-Phenylcarbamoyleseroline, (-)-Phenserine

     acetylcholinesterase inhibitor Phenserine Chemical Structure
  71. GC17391 Physostigmine hemisulfate

    cholinesterase inhibitor

     Physostigmine hemisulfate Chemical Structure
  72. GC38411 Picfeltarraenin IA Picfeltarraenin IA Chemical Structure
  73. GC36915 Picfeltarraenin IB Picfeltarraenin IB, a triterpenoid obtained from Picriafel-terrae Lour (P. Picfeltarraenin IB Chemical Structure
  74. GC36916 Picfeltarraenin IV Picfeltarraenin IV, a triterpenoid obtained from Picriafel-terrae Lour (P. Picfeltarraenin IV Chemical Structure
  75. GC60291 Pirimiphos-methyl Pirimiphos-methyl is a rapid-acting organophosphorus insecticide and acaricide, causing inhibition of AChE in target organisms. Pirimiphos-methyl Chemical Structure
  76. GC18207 Pitofenone (hydrochloride) Pitofenone is an antispasmodic agent and an inhibitor of acetylcholinesterase (AChE; Kis = 36 and 45 μM for bovine erythrocyte and electric eel enzyme, respectively). Pitofenone (hydrochloride) Chemical Structure
  77. GN10578 Polygalacic acid

    Virgaureagenin G

     Polygalacic acid Chemical Structure
  78. GC33684 Pralidoxime chloride (2-PAM chloride)

    2-PAM

     Pralidoxime chloride (2-PAM chloride) is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime chloride (2-PAM chloride) Chemical Structure
  79. GC39656 Pralidoxime iodide Pralidoxime iodide is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime iodide Chemical Structure
  80. GC11617 Pristimerin

    Celastrol methyl ester, NSC 99281

    monoacylglycerol lipase (MGL) inhibitor

     Pristimerin Chemical Structure
  81. GC61206 Profenofos Profenofos is an insecticida used on field crops, vegetables, and fruit crops. Profenofos Chemical Structure
  82. GC30856 Protriptyline hydrochloride

    Protryptyline

     Protriptyline hydrochloride is a tricyclic antidepressant (TCA), specifically a secondary amine, for the treatment of depression and ADHD. Protriptyline hydrochloride Chemical Structure
  83. GC39141 Pseudocoptisine acetate Pseudocoptisine (Isocoptisine) acetate is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine acetate Chemical Structure
  84. GC61566 Pseudocoptisine chloride Pseudocoptisine (Isocoptisine) chloride is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine chloride Chemical Structure
  85. GC15348 Pyridostigmine Bromide

    NSC 679759, Ro 1-5130

     Reversible cholinesterase inhibitor Pyridostigmine Bromide Chemical Structure
  86. GC34288 Pyridostigmine D6 bromide Pyridostigmine D6 bromide Chemical Structure
  87. GN10145 Rhodionin Rhodionin Chemical Structure
  88. GC37528 Rhodiosin Rhodiosin, isolated from the root of Rhodiola crenulata, is a specific non-competitive cytochrome P450 2D6 inhibitor with an IC50 of 0.420 μM and a Ki of 0.535 μM. Rhodiosin Chemical Structure
  89. GC10267 Rivastigmine A cholinesterase inhibitor Rivastigmine Chemical Structure
  90. GC64285 Rivastigmine carbamate impurity Rivastigmine carbamate impurity (3-Nitrophenyl ethyl(methyl)carbamate) is an impurity of Rivastigmine. Rivastigmine carbamate impurity Chemical Structure
  91. GC12994 Rivastigmine Tartrate

    Exelon, SDZENA 713

     AChR inhibitor Rivastigmine Tartrate Chemical Structure
  92. GC31699 Scopoletin (Gelseminic acid)

    Esculetin 6-methyl ether, 7-Hydroxy-6-methoxycoumarin, 6-Methoxy-7-hydroxycoumarin, NSC 405647

     Scopoletin (Gelseminic acid) is an inhibitor of acetylcholinesterase (AChE). Scopoletin (Gelseminic acid) Chemical Structure
  93. GC12123 sn-Glycero-3-phosphocholine

    Glycerophosphocholine, L-α-GPC, L-α-Glycerylphosphorylcholine, sn-glycero-3PC

    Nootropic phospholipid

     sn-Glycero-3-phosphocholine Chemical Structure
  94. GC33067 Sophoflavescenol Sophoflavescenol is a prenylated flavonol, which shows great inhibitory activity with IC50 of 0.013 μM against Phosphodiesterase 5 (PDE5), and also inhibits RLAR, HRAR, AGE, BACE1, AChE and BChE with IC50s of 0.30 ?M, 0.17 ?M, 17.89 ?g/mL, 10.98 ?M, 8.37 ?M and 8.21 ?M, respectively. Sophoflavescenol Chemical Structure
  95. GC12937 STF 083010

    IRE1 Inhibitor I

     STF 083010 is an inhibitor of endonuclease activity of Inositol requiring-enzyme 1α (IRE1α) with an IC50 value of 9.94µM for IRE-1 RNase STF 083010 Chemical Structure
  96. GC38982 Swertianolin Swertianolin, a xanthone isolated from Gentianella Acuta, inhibits acetylcholinesterase (AChE). Swertianolin Chemical Structure
  97. GC31044 T 82 T 82 is a potent 5-HT3 antagonist and acetylcholinesterase (AChE) inhibitor, used for treatment of Alzheimer's Disease. T 82 Chemical Structure
  98. GC12813 Tacrine hydrochloride

    C.I. 970, Hydroaminacrine

    cholinesterase inhibitor

     Tacrine hydrochloride Chemical Structure
  99. GC37718 Tacrine hydrochloride hydrate Tacrine hydrochloride hydrate is an inhibitor of both acetyl (AChE) and butyryl-cholinestrase (BChE) with IC50s of 31 nM and 25.6 nM, respectively. Tacrine hydrochloride hydrate Chemical Structure
  100. GN10616 Timosaponin AIII

    TAIII

     Timosaponin AIII inhibits the activity of acetylcholinesterase (AChE), with IC50 value of 35.4μM. Timosaponin AIII Chemical Structure
  101. GC38026 Violanthin

    Violanthin is isolated from the aerial parts of Piper bavinum, has potent antioxidant and antibacterial activities.

     Violanthin Chemical Structure

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