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Home >> Signaling Pathways >> Neuroscience >> CaMK

CaMK

The Ca2+/calmodulin-dependent kinase (CaMK) family has been recognized as a key mediator in living organisms and various biological processes.

Calcium/calmodulin kinase II (CaMK II) is a multifunctional cytoplasmic calcium and calmodulin-dependent protein kinase that phosphorylates and alters the function of a variety of substrates. The CaMK II pathway has been found to regulate the RANKL-induced osteoclast formation via the cAMP-response element binding protein (CREB) pathway.

Among many signaling pathways of proliferation, intracellular calciumol/L has been extensively demonstrated to be very important. In cytoplasm, calciumol/L binds to calmodulin, and then activates the Ca2+/calmodulin (CaM) dependent kinases (CaMKs) which are a family of structurally related serine/threonine protein kinases including CaMKI-IV. CaMKII, a multi functional protein kinase, is ubiquitously involved in many physiological processes including control of cell cycle, apoptosis, gene expression, and neurotransmission.

Targets for  CaMK

Products for  CaMK

  1. Cat.No. Product Name Information
  2. GC79781 8-Br-ADPR disodium

    8-Bromoadenosine-5'-O-diphosphoribose disodium

     8-Br-ADPR disodium (8-Bromoadenosine-5'-O-diphosphoribose) is a TRPM2 inhibitor and ADPR signaling pathway antagonist. 8-Br-ADPR disodium Chemical Structure
  3. GC12739 A 484954 A eukaryotic elongation factor-2 (eEF-2) kinase inhibitor A 484954 Chemical Structure
  4. GC60037 A-3 hydrochloride A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride Chemical Structure
  5. GC42831 AR420626 AR420626 is an oral active and selective agonist of free fatty acid receptor 3 (FFAR3) with an EC50 value of 2.2µM. AR420626 Chemical Structure
  6. GC33683 Autocamtide 2 (Autocamtide II)

    Autocamtide II

     Autocamtide 2 (Autocamtide II) is a highly selective peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). Autocamtide 2 (Autocamtide II) Chemical Structure
  7. GC34390 Autocamtide 2, amide Autocamtide 2, amide is a substrate (100 μM final concentration) for CaMK family assays. Autocamtide 2, amide Chemical Structure
  8. GC35432 Autocamtide-2-related inhibitory peptide (TFA) Autocamtide-2-related inhibitory peptide (TFA) Chemical Structure
  9. GC91849 Autocamtide-2-related Inhibitory Peptide (trifluoroacetate salt) Autocamtide-2-related inhibitory peptide is a calmodulin-dependent protein kinase II (CaMKII) inhibitor (IC50 = 40 nM) that was designed based on the sequence around the autophosphorylation site (Thr286/Thr287) in the autoinhibitory domain of the protein kinase. Autocamtide-2-related Inhibitory Peptide (trifluoroacetate salt) Chemical Structure
  10. GC50305 Autocamtide-2-related inhibitory peptide, myristoylated CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory peptide Autocamtide-2-related inhibitory peptide, myristoylated Chemical Structure
  11. GC72206 Autocamtide-3 acetate Autocamtide-3 acetate, a 13-amino-acid peptide containing Thr287, is a selective CaMKII (Ca2+/calmodulin-dependent kinase II) (CaMK) substrate. Autocamtide-3 acetate Chemical Structure
  12. GC79486 Bacoside A (mixture) Bacoside A (mixture) is a mixture composed of Bacoside A3, Bacopaside II, Bacopaside X and Bacopasaponin C. Bacoside A (mixture) Chemical Structure
  13. GC14326 Calmidazolium chloride

    R 24571

     Calmidazolium chloride is a very potent inhibitor of several Ca2+-calmodulin-dependent enzymes, the IC50 values are 0.01μM for brain phosphodiesterase, 0.2μM for erythrocyte Ca2+-ATPase and 5.0μM for phosphorylase b kinase. Calmidazolium chloride Chemical Structure
  14. GC43128 Calmodulin-Dependent Protein Kinase II (290-309) (trifluoroacetate salt) Calmodulin-dependent protein kinase II (290-309) is a synthetic peptide derived from the rat brain protein sequence that contains the calmodulin binding domain. Calmodulin-Dependent Protein Kinase II (290-309) (trifluoroacetate salt) Chemical Structure
  15. GC31170 Calmodulin-Dependent Protein Kinase II 290-309 Calmodulin-Dependent Protein Kinase II 290-309 is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II. Calmodulin-Dependent Protein Kinase II 290-309 Chemical Structure
  16. GC61521 Calmodulin-Dependent Protein Kinase II(290-309) acetate Calmodulin-Dependent Protein Kinase II (290-309) acetate is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II. Calmodulin-Dependent Protein Kinase II(290-309) acetate Chemical Structure
  17. GC35601 CaMKII-IN-1 CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor with an IC50 value of 63nM. CaMKII-IN-1 Chemical Structure
  18. GC79775 CaMKIIδ-IN-1 hydrochloride CaMKIIδ-IN-1 (Compound 15e) hydrochloride is a pyrimidine-based inhibitor of CaMKIIδ with an IC50 of 12 nM [1]. CaMKIIδ-IN-1 hydrochloride Chemical Structure
  19. GC79076 Chktide acetate Chktide acetate is a synthetic peptide substrate applicable for activity assays of Chk1 kinase and cyk/CaMKII. Chktide acetate Chemical Structure
  20. GC71066 CS587 CS587 is a specific inhibitor of CaMK1D with neurocytotoxicity at 10 μM. CS587 Chemical Structure
  21. GC35820 DDD107498 succinate

    DDD107498 succinate; DDD-498 succinate; M5717 succinate

     DDD107498 succinate (DDD-498 succinate) is a potent and orally active antimalarial agent, inhibits multiple life-cycle stages of the parasite, with an EC50 of 1 nM against P. DDD107498 succinate Chemical Structure
  22. GC11362 K 252a

    SF 2370

     A protein kinase inhibitor K 252a Chemical Structure
  23. GC14202 KN-62 KN-62 is a selective calmodulin-dependent protein kinase II (CaMKII) inhibitor and also a potent non-competitive P2X7 receptor antagonist. KN-62 Chemical Structure
  24. GC14132 KN-92

    KN 92;KN92

     An inactive control compound for a CaMKII inhibitor KN-92 Chemical Structure
  25. GC15988 KN-92 hydrochloride

    KN-92 hydrochloride is an inactive analogue of KN-93 and can be converted to KN-93 by modification.

     KN-92 hydrochloride Chemical Structure
  26. GC16981 KN-92 phosphate KN-92 phosphate Chemical Structure
  27. GC10629 KN-93 KN-93 is an effective, cell-membrane permeable, and selective inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with an IC50 value of 0.37μM. KN-93 Chemical Structure
  28. GC12501 KN-93 hydrochloride KN-93 hydrochloride is an effective, cell-membrane permeable, and selective inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with an IC50 value of 0.37μM. KN-93 hydrochloride Chemical Structure
  29. GC12804 KN-93 Phosphate KN-93 Phosphate is an effective, cell-membrane permeable, and selective inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with an IC50 value of 0.37μM. KN-93 Phosphate Chemical Structure
  30. GC30356 Metofenazate (Methophenazine) Metofenazate (Methophenazine) is a selective calmodulin inhibitor. Metofenazate (Methophenazine) Chemical Structure
  31. GC17329 MLCK inhibitor peptide 18

    Myosin Light Chain Kinase Inhibitor Peptide 18

     Selective competitive inhibitor of myosin light chain kinase MLCK inhibitor peptide 18 Chemical Structure
  32. GC13793 NH125 NH125 is a multitarget active substance and an inhibitor of several members of the histidine protein kinase family. NH125 can inhibit the activity of eukaryotic elongation factor-2 kinase (eEF-2K) with an IC50 of 60nM . NH125 Chemical Structure
  33. GC33775 Rimacalib (SMP 114)

    SMP 114

     Rimacalib (SMP 114) (SMP 114) is a Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor, with IC50s of ~1 μM for CaMKIIα to ~30 μM for CaMKIIγ. Rimacalib (SMP 114) Chemical Structure
  34. GC79519 SKF-96365 SKF-96365 is a TRPC channel antagonist and store-operated calcium entry ( SOCE ) inhibitor. SKF-96365 Chemical Structure
  35. GC37694 STO-609 STO-609 is a selective and cell-permeable inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK), with Ki values of 80 and 15ng/mL for recombinant CaM-KKα and CaM-KKβ, respectively. STO-609 Chemical Structure
  36. GC33732 Syntide 2 A protein kinase substrate Syntide 2 Chemical Structure
  37. GC37710 Syntide 2 (TFA) Syntide 2 (TFA) Chemical Structure
  38. GC71047 TIM-063 TIM-063 is a selective and cell-permeable CaMKK inhibitor, ATP competitive inhibitor, can directly target the catalytic domain of CaMKK, with the Ki values of 0.35 μM and 0.2 μM for CaMKKα and CaMKKβ, respectively, the IC50 values are 0.63 μM and 0.96 μM, respectively. TIM-063 Chemical Structure
  39. GC62146 XST-14 XST-14 is a potent, competitive and highly selective ULK1 inhibitor with an IC50 of 26.6 nM. XST-14 induces autophagy inhibition by reducing the phosphorylation of the ULK1 downstream substrate. XST-14 induces apoptosis in hepatocellular carcinoma (HCC) cells and has antitumor effects. XST-14 Chemical Structure

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