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Home >> Signaling Pathways >> Immunology/Inflammation >> PGE synthase

PGE synthase

Prostagladin E synthase catalzyes the oxidoreduction of PGHS (prostaglandin endoperoxde h2) into PGE2(prostaglandin E2). It is implicated in physiological conditions such as fever, pain and arthritis etc.

Products for  PGE synthase

  1. Cat.No. Product Name Information
  2. GC15058 Benzydamine HCl Benzydamine HCl is a locally-acting nonsteroidal anti-inflammatory drug with local anaesthetic and analgesic properties; selectively binds to prostaglandin synthetase and has notable in vitro antibacterial activity. Benzydamine HCl Chemical Structure
  3. GC17707 Bismuth Subsalicylate Prostaglandin G/H Synthase 1/2 inhibitor Bismuth Subsalicylate Chemical Structure
  4. GC40352 Cafestol Cafestol is a natural diterpene which is abundant in unfiltered coffee. Cafestol Chemical Structure
  5. GC18904 CAY10678

    mPGES-1 Inhibitor III

     Microsomal prostaglandin E synthase-1 (mPGES-1) converts the COX product PGH2 into the biologically active PGE2. CAY10678 Chemical Structure
  6. GC38431 Dehydroevodiamine Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, has an antiarrhythmic effect in guinea-pig ventricular myocytes. Dehydroevodiamine Chemical Structure
  7. GC38678 Ethyl Caffeate Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl Caffeate Chemical Structure
  8. GC16880 Flurbiprofen

    Ansaid

     Cyclooxygenase inhibitors Flurbiprofen Chemical Structure
  9. GC14633 HPGDS inhibitor 1

    H-PGDS Inhibitor I

     HPGDS inhibitor HPGDS inhibitor 1 Chemical Structure
  10. GC36254 HPGDS inhibitor 2 HPGDS inhibitor 2 is a highly potent and selective hematopoietic prostaglandin D synthase (H-PGDS) inhibitor with an IC50 of 9.9 nM. HPGDS inhibitor 2 Chemical Structure
  11. GC10564 HQL 79 human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor HQL 79 Chemical Structure
  12. GC36463 Limaprost

    17α,20dimethylΔ2PGE1, 17α,20dimethylΔ2Prostaglandin E1

     A stable, potent analog of PGE1 Limaprost Chemical Structure
  13. GC16607 Mesalamine

    5-ASA

     5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB. Mesalamine Chemical Structure
  14. GC11743 MF63 A potent, selective, and orally active mPGES-1 inhibitor MF63 Chemical Structure
  15. GC36649 mPGES1-IN-3 mPGES1-IN-3 (Compound 17d) is a potent and selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor, which exhibits excellent mPGES-1 enzyme (IC50: 8 nM), cell (A549 IC50: 16.24 nM) and human whole blood potency (IC50: 249.9 nM). mPGES1-IN-3 Chemical Structure
  16. GC18700 PF-4693627 PF-4693627 is an orally bioavailable inhibitor of microsomal prostaglandin E (PGE) synthase-1 (mPGES-1; IC50 = 3 nM). PF-4693627 Chemical Structure
  17. GC32038 PGS-IN-1 (KME-4)

    KME-4

     PGS-IN-1 (KME-4) is a potent inhibitor of prostaglandin synthetase (PGS) with an IC50 of 0.28 μM; also inhibits 5-lipoxygenase with an IC50 of 1.05 μM. PGS-IN-1 (KME-4) Chemical Structure
  18. GC11670 Pranoprofen

    Pyranoprofen, Y 8004

     non-steroidal COX inhibitor Pranoprofen Chemical Structure
  19. GC12330 SAR191801 SAR191801 is a hPGDS inhibitor ,with IC50 of 12 nM in the Fluorescence Polarization Assay or the EIA assay. SAR191801 Chemical Structure
  20. GN10280 Sinensetin

    Pedalitin Permethyl ether

     Sinensetin Chemical Structure
  21. GC14438 Suprofen

    NSC 303611, R 25061, (±)-Suprofen, TN 762

     dual COX-1/COX-2 inhibitor Suprofen Chemical Structure
  22. GC50101 TFC 007 Potent hematopoietic prostaglandin D synthase (H-PGDS) inhibitor TFC 007 Chemical Structure
  23. GC70119 Vipoglanstat

    BI 1029539; GS-248; OX-MPI

    Vipoglanstat (BI 1029539), also known as formylamide, is an effective, selective, non-peptide small molecule inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1) with oral activity. Vipoglanstat also has anti-inflammatory activity.

     Vipoglanstat Chemical Structure
  24. GC63394 Zaloglanstat

    ISC-27864; GRC-27864

     Zaloglanstat (ISC-27864) is the inhibitor of the microsomal prostaglandin E synthase-1 (mPGES-1), and can be used to study asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases, etc. Zaloglanstat Chemical Structure
  25. GC31687 Zomepirac sodium salt (McN-2783-21-98) Zomepirac sodium salt (McN-2783-21-98) (McN-2783-21-98) is a potent prostaglandin biosynthesis inhibitor. Zomepirac sodium salt (McN-2783-21-98) Chemical Structure

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