Membrane Transporter/Ion Channel

WO662 (compound I-1a) is a KCNT1 inhibitor with an IC 50 ≤ 250 nM.

ShK toxin TFA (Stichodactyla helianthus neurotoxin TFA) is a neurotoxin.

E0199 is a novel potent dual-target K V 7/Na V modulator that activates the K V 7 channel (K V 7.2/7.3 ( EC 50 = 12.78 nM), K V 7.2 ( EC 50 = 0.50 μM), and K V 7.5 ( EC 50 = 27.14 nM) channels) while simultaneously blocks the Na V 1.7 ( IC 50 = 0.52 μM), Na V 1.8 ( IC 50 = 0.24 μM), and Na V 1.9 ( IC 50 = 0.16 μM) channels.

Zastaprazan (JP-1366) citrate is a Proton pump inhibitor and potent potassium-competitive acid blocker.

MK-5661 is an orally potent Na V 1.8 voltage-gated sodium channel inhibitor with an EC 50 of 4.3 nM.

Cotransin TFA is a cyclic ester peptide and a Sec61 translocator binder with signal sequence-selective activity to inhibit co-translational protein translocation.

Nav1.7-IN-19 is a potent, selective and orally active Nav1.7 inhibitor with an IC 50 of 0.49 μM.

FJ9 is a NHERF1/PDZ inhibitor with human NHERF1 PDZ1 IC 50 1540 μM, NHERF1 PDZ2 IC 50 160 μM, and Frizzled-7-Dishevelled PDZ complex K i 10 μM.

HK2-IN-4 is a selective hexokinase 2 ( HK2 ) inhibitor with an IC 50 value of 0.79 μM and a K d value of 0.41 μM.

ATX-012 is an ionizable cationic lipid for the assembly of mRNA -delivering lipid nanoparticles (LNPs).

Alofropodect is an orally active, blood-brain barrier permeable phosphodiesterase 10A ( PDE10A ) inhibitor with IC 50 values of 1 nM (Reference 1) and 35 nM (Reference 2).

8-Br-ADPR disodium (8-Bromoadenosine-5'-O-diphosphoribose) is a TRPM2 inhibitor and ADPR signaling pathway antagonist.

4''-Oxoavermectin B1a is a potentiator targeting GABA (γ-aminobutyric acid) and glutamate-gated chloride channels with insecticidal and acaricidal activities.

(S)-IDOR-1117-2520 is the S-isomer of IDOR-1117-2520.

ω-Hexatoxin-Hv1a (ω-ACTX-Hv1; ω-Atracotoxin-HV1) TFA is an orally active insecticidal neurotoxin containing an inhibitor cystine knot motif and a selective calcium channel inhibitor.

Suzetrigine N-oxide (the third compound in P57) is a derivative of Suzetrigine.

JNJ 303 -d 3 is the deuterium labeled JNJ 303.

Pregnenolone -d 6 (3β-Hydroxy-5-pregnen-20-one-d 6 ) is the deuterium labeled Pregnenolone [1] . Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones.

Arecoline-d 5 hydrobromide is the deuterium labeled Arecoline hydrobromide.

(S)-TROX-1 is the S-enantiomer of TROX-1.

Acoltremon -d 3 (WS-12-d 3 ) is the deuterium labeled Acoltremon.

Spironolactone -d 6 -1 is the deuterium labeled Spironolactone.

Anandamide - 15 N (AEA- 15 N) is the 15 N-labeled Anandamide.

Papaveroline is a Fyn tyrosine kinase inhibitor, Na +,K + -ATPase inhibitor with an IC 50 of 0.20 mM, Mg 2+ -ATPase inhibitor, K + -activated pNPPase inhibitor with an IC 50 of 1.51 mM, and apoptosis inducer [1] [2] [3] . Papaveroline binds to the active site of Fyn tyrosine kinase and forms stable interactions with pocket amino acid residues [1] . Papaveroline induces cell apoptosis, produces pycnotic and fragmented cell nuclei, and does not reduce intracellular ATP levels [3] . Papaveroline is a dopamine-derived neurotoxin candidate associated with the pathogenesis of Parkinson's disease [3] . Papaveroline can be used in the research of Alzheimer's disease and Parkinson's disease [3] .