Na+/K+ ATPase
Na+/K+ ATPase (Sodium potassium pump) is a transmembrane protein complex found in all higher eukaryotes acting as a key energy-consuming pump maintaining ionic and osmotic balance in cells. Na+/K+ ATPase is an emerging cancer target that merits further investigation.
The constant activity of the Na+/K+-ATPase (NKA, or Na+ pump) is essential for re-establishing and maintaining this gradient. In cardiac and vascular smooth muscle the principal isoforms of the NKA are α1 and α2 and their physiological role is controlled both by their unique and independent signalling pathways, and their discrete subcellular distribution.
Targets for Na+/K+ ATPase
Products for Na+/K+ ATPase
- Cat.No. Product Name Information
- GC32130 (+)-SJ733 (SJ000557733) (+)-SJ733 (SJ000557733) is an anti-malaria agent which can also inhibit Na+-ATPase PfATP4.
- GC30927 Acevaltrate Acevaltrate inhibits the Na+/K+-ATPase activity in the rat kidney and brain hemispheres with IC50s of 22.8 μM and 42.3 μM, respectively.
- GC18203 Annonacin Annonacin is a potent and lipophilic acetogenin from A.
- GN10365 Bufalin
- GC17086 Chlorpropamide Oral antihyperglycemic agent
- GC41514 Citreoviridin Citreoviridin is a mycotoxin isolated from several Penicillium species that has been shown to inhibit the mitochondrial ATP synthetase system.
- GC38903 Deslanoside A cardiac glycoside
- GC34013 Digitoxin A cardiac glycoside with diverse biological activities
- GC13108 Digoxin Na+/K+ ATPase pump inhibitor
- GN10156 Ginsenoside Rb1
- GC64887 Gitoxin Gitoxin, a Na+/K+-ATPase inhibitor, usually appears as a result of metabolic degradation of Digitoxin, is just the hydroxyl (ZOH) group close to the C-17β position, which changes the pharmacokinetics and pharmacodynamics of these substances considerably.
- GC11448 Istaroxime
- GC17786 Istaroxime hydrochloride
- GC18189 Marinobufagenin Marinobufagenin is a strong inhibitor of Na+/K+ ATPase that has been identified in mammalian plasma.
- GC61628 Neriifolin Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na+, K+-ATPase.
- GN10144 Oleandrin
- GC30110 Oleic acid (9-cis-Octadecenoic acid) Oleic acid (9-cis-Octadecenoic acid) (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid.
-
GC10579
Ouabain Octahydrate
selective Na+/K+-ATPase inhibitor
- GN10029 Phloridzin
- GC15071 Prilocaine local anesthetic of the amino amide type
- GC13162 Prilocaine hydrochloride Local anesthetic of the amino amide type
- GC12413 Rostafuroxin (PST 2238) Rostafuroxin (PST 2238) (PST 2238), a digitoxigenin derivative, is an orally active and potent Na+,K+-ATPase (ATP1A1) antognist.
- GC19522 Sodium oleate Sodium oleate (Oleic acid sodium) is an abundant monounsaturated fatty acid sodium.
- GC63832 Strophanthidin Strophanthidin is a naturally available cardiac glycoside.
- GC30535 Transdermal Peptide (TD 1 (peptide)) Transdermal Peptide (TD 1 (peptide)), consisting of 11 amino acids, is the first transdermal enhancing peptide discovered by phage display.
- GC61345 Transdermal Peptide Disulfide TFA Transdermal Peptide Disulfide TFA (TD 1 Disulfide(peptide) TFA) is a 11-amino acid peptide, binds to Na+/K+-ATPase beta-subunit (ATP1B1), and mainly interacts with the C-terminus of ATP1B1.
- GC38869 Transdermal Peptide TFA