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Home >> Signaling Pathways >> Membrane Transporter/Ion Channel >> Na+/K+ ATPase

Na+/K+ ATPase

Na+/K+ ATPase (Sodium potassium pump) is a transmembrane protein complex found in all higher eukaryotes acting as a key energy-consuming pump maintaining ionic and osmotic balance in cells. Na+/K+ ATPase is an emerging cancer target that merits further investigation.

The constant activity of the Na+/K+-ATPase (NKA, or Na+ pump) is essential for re-establishing and maintaining this gradient. In cardiac and vascular smooth muscle the principal isoforms of the NKA are α1 and α2 and their physiological role is controlled both by their unique and independent signalling pathways, and their discrete subcellular distribution.

Targets for  Na+/K+ ATPase

Products for  Na+/K+ ATPase

  1. Cat.No. Product Name Information
  2. GC32130 (+)-SJ733 (SJ000557733)

    SJ000557733

     (+)-SJ733 (SJ000557733) is an anti-malaria agent which can also inhibit Na+-ATPase PfATP4. (+)-SJ733 (SJ000557733) Chemical Structure
  3. GC30927 Acevaltrate Acevaltrate inhibits the Na+/K+-ATPase activity in the rat kidney and brain hemispheres with IC50s of 22.8 μM and 42.3 μM, respectively. Acevaltrate Chemical Structure
  4. GC18203 Annonacin Annonacin is a potent and lipophilic acetogenin from A. Annonacin Chemical Structure
  5. GN10365 Bufalin

    NSC 89595

     Bufalin Chemical Structure
  6. GC17086 Chlorpropamide

    NSC 44634, NSC 626720

     Oral antihyperglycemic agent Chlorpropamide Chemical Structure
  7. GC41514 Citreoviridin Citreoviridin is a mycotoxin isolated from several Penicillium species that has been shown to inhibit the mitochondrial ATP synthetase system. Citreoviridin Chemical Structure
  8. GC38903 Deslanoside

    Desacetyllanatoside C

     A cardiac glycoside Deslanoside Chemical Structure
  9. GC34013 Digitoxin

    Digitoxoside, Lanatoxin, NSC 7529

     A cardiac glycoside with diverse biological activities Digitoxin Chemical Structure
  10. GC13108 Digoxin

    NSC 95100

     Digoxin is a potent Na+/K+-ATPase inhibitor clinically used to treat arrhythmias and heart failure. Digoxin Chemical Structure
  11. GN10156 Ginsenoside Rb1

    Gypenoside III, NSC 310103

     Ginsenoside Rb1 Chemical Structure
  12. GC64887 Gitoxin Gitoxin, a Na+/K+-ATPase inhibitor, usually appears as a result of metabolic degradation of Digitoxin, is just the hydroxyl (ZOH) group close to the C-17β position, which changes the pharmacokinetics and pharmacodynamics of these substances considerably. Gitoxin Chemical Structure
  13. GC11448 Istaroxime

    PST-2744;PST 2744;PST2744

     Istaroxime Chemical Structure
  14. GC17786 Istaroxime hydrochloride Istaroxime hydrochloride Chemical Structure
  15. GC18189 Marinobufagenin

    Marinobufagin, MBG, NSC 234205

     Marinobufagenin is a strong inhibitor of Na+/K+ ATPase that has been identified in mammalian plasma. Marinobufagenin Chemical Structure
  16. GC61628 Neriifolin Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na+, K+-ATPase. Neriifolin Chemical Structure
  17. GN10144 Oleandrin

    Folinerin, Neriolin

     Oleandrin Chemical Structure
  18. GC30110 Oleic acid (9-cis-Octadecenoic acid)

    9Z-Octadecenoic Acid, C18:1(9Z), cis-9-Octadecenoic acid

     Oleic acid (9-cis-Octadecenoic acid) is a monounsaturated Omega-9 fatty acid found in plants and animals. Oleic acid (9-cis-Octadecenoic acid) Chemical Structure
  19. GC10579 Ouabain Octahydrate

    selective Na+/K+-ATPase inhibitor

     Ouabain Octahydrate Chemical Structure
  20. GN10029 Phloridzin

    Floridzin, NSC 2833

     Phloridzin Chemical Structure
  21. GC15071 Prilocaine local anesthetic of the amino amide type Prilocaine Chemical Structure
  22. GC13162 Prilocaine hydrochloride Local anesthetic of the amino amide type Prilocaine hydrochloride Chemical Structure
  23. GC12413 Rostafuroxin (PST 2238)

    PST 2238

     Rostafuroxin (PST 2238) (PST 2238), a digitoxigenin derivative, is an orally active and potent Na+,K+-ATPase (ATP1A1) antognist. Rostafuroxin (PST 2238) Chemical Structure
  24. GC19522 Sodium oleate

    cis-9-Octadecenoic acid sodium salt, Oleic acid sodium salt

    Sodium oleate (Oleic acid sodium) is an abundant monounsaturated fatty acid sodium. Sodium oleate Chemical Structure
  25. GC63832 Strophanthidin Strophanthidin is a naturally available cardiac glycoside. Strophanthidin Chemical Structure
  26. GC30535 Transdermal Peptide (TD 1 (peptide))

    Transdermal Peptide (TD 1 (peptide)), consisting of 11 amino acids, is the first transdermal enhancing peptide discovered by phage display.

     Transdermal Peptide (TD 1 (peptide)) Chemical Structure
  27. GC61345 Transdermal Peptide Disulfide TFA

    TD 1 Disulfide(peptide) TFA

     Transdermal Peptide Disulfide TFA (TD 1 Disulfide(peptide) TFA) is a 11-amino acid peptide, binds to Na+/K+-ATPase beta-subunit (ATP1B1), and mainly interacts with the C-terminus of ATP1B1. Transdermal Peptide Disulfide TFA Chemical Structure
  28. GC38869 Transdermal Peptide TFA Transdermal Peptide TFA Chemical Structure

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