Chloride Channel
Chloride channels represent a relatively under-explored target class for drug discovery as elucidation of their identity and physiological roles has lagged behind that of many other drug targets. Chloride channels are involved in a wide range of biological functions, including epithelial fluid secretion, cell-volume regulation, neuroexcitation, smooth-muscle contraction and acidification of intracellular organelles. Mutations in several chloride channels cause human diseases, including cystic fibrosis, macular degeneration, myotonia, kidney stones, renal salt wasting and hyperekplexia. Chloride-channel modulators have potential applications in the treatment of some of these disorders, as well as in secretory diarrhoeas, polycystic kidney disease, osteoporosis and hypertension.
Chloride channel accessory proteins, also known as calcium-activated chloride channel regulators (CLCA proteins), are a family of transmembrane proteins that have been suggested to have a role in chloride conductance in epithelial cells.
Targets for Chloride Channel
Products for Chloride Channel
- Cat.No. Product Name Information
- GC19021 Adjudin Adjudin is an extensively studied male contraceptive with a superior mitochondria-inhibitory effect.
- GC46086 Ani 9 An inhibitor of ANO1
- GC14768 CaCCinh-A01 calcium-activated chloride channel (CaCC) inhibitor
- GC33024 Chlorotoxin Chlorotoxin is a 36 amino-acid peptide from the venom of the Israeli scorpion Leiurus quinquestriatus with anticancer activity. Chlorotoxin is a chloride channel blocker.
- GC38498 Chlorotoxin (TFA)
- GC14073 DCPIB volume-sensitive anion channel (VSAC) and and ICl,swell blocker
-
GC18142
Eact
TMEM16A (ANO1) calcium-activated chloride channel (CaCC) activator
- GC34574 Endovion Endovion (NS3728) is a pharmacological anion channel inhibitor (like chloride channel) and the specific VRAC/VSOAC blocker.
- GC60834 Fenamic acid Fenamic acid (N-Phenylanthranilic acid, NPAA) is an orally active chloride channel blocker.
-
GC13466
Flufenamic acid
TRPC activator
- GC30555 H100 H100 is a Cl- transport inhibitor, with partial effects against both the NaK2Cl cotransporter and the Band 3 anion exchanger, but no effect against KCl cotransporter, in human erythrocytes.
- GC15308 IAA-94 IAA-94 (R(+)-Methylindazone) is a potent indanyloxyacetic acid blocker of epithelial chloride channels.
- GC63514 Irisolidone Irisolidone is a major isoflavone found in Pueraria lobata flowers.
- GC16890 Lubiprostone activator of ClC-2 chloride channels
- GC11069 Meticrane Peripheral-type benzodiazepine receptor (PBR) inhibitor
- GC18358 MONNA MONNA is a selective inhibitor of anoctamin-1 (ANO1; IC50 = 0.08 uM in Xenopus oocytes), a calcium-activated chloride channel (CaCC).
- GC16564 Niflumic acid Ca2+-activated Cl- channel blocker
-
GC14268
NPPB
inhibitor of chloride channel
- GC31133 NS1652 NS1652 is a reversible anion conductance inhibitor, blocks chloride channel, with an IC50 of 1.6 μM in human and mouse red blood cells.
- GC61186 Picrotoxinin Picrotoxinin, a potent convulsant, is a chloride channel blocker.
- GN10216 Shikonin
- GC65406 T16A(inh)-C01 T16A(inh)-C01 is an inhibitor of TMEM16A (ANO1).
- GC17930 T16Ainh - A01 Inhibit transient TMEM16A-mediated chloride currents