nAChR
nAChRs (nicotinic acetylcholine receptors) are neuron receptor proteins that signal for muscular contraction upon a chemical stimulus. They are cholinergic receptors that form ligand-gated ion channels in the plasma membranes of certain neurons and on the presynaptic and postsynaptic sides of theneuromuscular junction. Nicotinic acetylcholine receptors are the best-studied of the ionotropic receptors. Like the other type of acetylcholine receptor-the muscarinic acetylcholine receptor (mAChR)-the nAChR is triggered by the binding of the neurotransmitter acetylcholine (ACh). Just as muscarinic receptors are named such because they are also activated by muscarine, nicotinic receptors can be opened not only by acetylcholine but also by nicotine —hence the name "nicotinic".
Targets for nAChR
Products for nAChR
- Cat.No. Product Name Information
- GC63269 α-Conotoxin PIA TFA
- GC63723 α-Conotoxin PnIA TFA
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GC70179
α7 Nicotinic receptor agonist-1
Alpha-7 Nicotinic receptor agonist-1 (Preparation 5) is an alpha-7 nAChR agonist. It can be used for research on psychiatric disorders such as schizophrenia, mania or bipolar disorder, and anxiety disorders, as well as intellectual disabilities such as Alzheimer's disease, learning deficits, cognitive impairments, attention deficits, memory loss, Lewy body dementia and attention deficit hyperactivity disorder.
- GC14410 (±)-Epibatidine nicotinic agonist
- GC34959 (+)-Sparteine (+)-Sparteine is a natural alkaloid acting as a ganglionic blocking agent.
- GC31084 (-)-(S)-B-973B
- GC14157 (-)-Lobeline hydrochloride nicotinic receptor partial agonist
- GC63511 (Rac)-CP-601927 hydrochloride (Rac)-CP-601927 hydrochloride is the racemate of CP-601927.
- GC64735 (S)-(-)-Levamisole (S)-(-)-Levamisole (Levamisole), an anthelmintic agent with immunomodulatory properties.
- GC60423 (S)-UFR2709 hydrochloride (S)-UFR2709 (hydrochloride) is a competitive nAChR antagonist?and displays higher affinity for α4β2 nAChRs than for α7 nAChRs.
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GC69979
(S)-VQW-765
(S)-VQW-765 ((S)-AQW-051) is a partial agonist of the α7 nicotinic acetylcholine receptor (nAChR) with oral activity, selectivity and efficacy. It has potential applications in cognitive impairments associated with neurological diseases such as Alzheimer's disease or schizophrenia.
- GC11757 3-Bromocytisine α4β4, α4β2 and α7 nACh receptor agonist
- GC18631 4BP-TQS An agonist of α7 subunit-containing nAChRs
- GC60026 5-AAM-2-CP 5-AAM-2-CP is a major metabolite of Acetamiprid.
- GC60027 5-AMAM-2-CP 5-AMAM-2-CP is a major metabolite of Acetamiprid.
- GC50088 A 85380 dihydrochloride High affinity and selective α4β2 nAChR agonist
- GC15014 A-867744 A positive allosteric modulator of α7 nAChRs
- GC60549 ABT-418 hydrochloride ABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities.
- GC13542 Adiphenine HCl Adiphenine HCl is a non-competitive inhibitor of nicotinic acetylcholine receptor (nAChR), with an IC50s of 1.9, 1.8, 3.7, and 6.3 μM for α1, α3β4, α4β2, and α4β4, respectively.
- GC30866 Anabasine ((S)-Anabasine) Anabasine ((S)-Anabasine) ((S)-Anabasine ((S)-Anabasine)) is an alkaloid that found as a minor component in tobacco (Nicotiana).
- GC39254 Anatabine dicitrate Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier.
- GC17695 Aniracetam Nootropic drug for senile dementia
- GC45387 Aspergillimide Aspergillimide ((rel)-Aspergillimide), an anthelmintic metabolite, is isolated from okara that has been fermented with Aspergillus japonicas JV-23.
- GC15667 Atracurium Besylate Neuromuscular blocking agent
- GC14339 Benzethonium Chloride Potent inhibitor of nAChRs
- GC35538 BNC375 BNC375 is a potent, selective, and orally available type I positive allosteric modulator of α7 nAChRs with an EC50 of 1.9 μM.
- GC64064 Bradanicline Bradanicline is a highly selective α7 nicotinic acetylcholine receptor (nAChR) agonist (humanα7 nAChR: EC50=17 nM; Ki= 1.4 nM).
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GC16937
Carbamoylcholine chloride
Cholinergic receptor agonist
- GC50126 CC4 High affinity and subtype-selective α6β2 and α4β2 nAChR partial agonist
- GC12119 CCMI Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors (nAChR)
- GC16911 CGS 9343B CGS 9343B (CGS-9343B) is a potent, orally active and selective inhibitor of calmodulin.
- GC43261 Cholesteryl Myristate Cholesteryl Myristate is a natural steroid present in traditional Chinese medicine. Cholesteryl Myristate binds to several ion channels such as the nicotinic acetylcholine receptor, GABAA receptor, and the inward-rectifier potassium ion channel.
- GC12226 Cisatracurium Besylate Neuromuscular-blocking drug
- GC50306 CMPI hydrochloride Potent positive allosteric modulator of α4β2 nAChRs; also inhibitor of (α4)2(β2)3, muscle-type and Torpedo nAChRs
- GC63868 COG 133 TFA COG 133 TFA is a fragment of Apolipoprotein E (APOE) peptide.
- GC63582 CP-601927 CP-601927 is a selective α4β2 nicotinic acetylcholine receptor (nAChR) partial agonist (Ki=1.2 nM; EC50=2.6 μM).
- GC63583 CP-601932 CP-601932 ((1S,5R)-CP-601927) is a high-affinity partial agonist at α3β4 nAChR (Ki=21?nM; EC50=~ 3?μM).
- GC31209 Cyclodrine hydrochloride Cyclodrine hydrochloride is a cholinergic (muscarinic, nicotinic) (mAChR and nAChR) receptor antagonist.
- GN10126 Cytisine
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GC60797
D-Tubocurarine chloride pentahydrate
D-Tubocurarine chloride pentahydrate is the chloride salt form of Tubocurarine, a nicotinic acetylcholine receptors (AChR) antagonist, and can be used as a skeletal muscle relaxant during surgery or mechanical ventilation.
- GC16255 Decamethonium Bromide Nicotinic AChR partial agonist
- GC12593 Desformylflustrabromine hydrochloride Positive allosteric modulator of nicotinic α4β2 receptors
- GC35858 Dianicline Dianicline is a α4β2 nicotinic acetylcholine receptor partial agonist, a class of drugs that includes varenicline and cytisine for smoking cessation.
- GC32185 Dinotefuran (MTI-446) Dinotefuran (MTI-446) is an insecticide of the neonicotinoid class, its mechanism of action involves disruption of the insect's nervous system by inhibiting nicotinic acetylcholine receptors.
- GC15941 EVP-6124 A partial agonist of α7 subunit-containing nAChRs
- GC11091 EVP-6124 hydrochloride A partial agonist of α7 subunit-containing nAChRs
- GC39748 Facinicline hydrochloride Facinicline hydrochloride (RG3487 hydrochloride) is an orally active nicotinic α7 receptor partial agonist, with a Ki of 6 nM for α7 human nAChR.
- GC60165 Ferulamide Ferulamide is a Ferulic acid derivative isolated from Portulaca oleracea L.
- GC66073 Flupyradifurone Flupyradifurone is a systemic nAChR agonist that interferes with signal transduction in the central nervous system of sucking pests. Flupyradifurone can be used as a butenolide insecticide.
- GC64394 Flupyrimin Flupyrimin acts as an antagonist at the insect nicotinic acetylcholine receptor (nAChR).
- GC10913 GTS 21 dihydrochloride nAChRs agonist, novel
- GA22579 H-Ile-Trp-OH H-Ile-Trp-OH (H-Ile-Trp-OH) is an orally active α7 nAChR negative alteration modulator (NAM) with no apparent side effects.
- GC15178 Hexamethonium Bromide Selective antagonist of neuronal-type nicotinic AChR
- GC43877 Hydroxy Bupropion Buproprion is an inhibitor of the reuptake of dopamine and norepinephrine and is also an antagonist of neuronal acetylcholine nicotinic receptors.
- GC63928 Iptakalim hydrochloride Iptakalim hydrochloride, a lipophilic para-amino compound, is a novel ATP-sensitive potassium channel (KATP) opener, as well as an α4β2-containing nicotinic acetylcholine receptor (nAChR) antagonist.
- GC63548 Ispronicline Ispronicline (TC-1734), an orally active, brain-selective α4β2 nicotine acetylcholine receptor (nAChR) partial agonist, has shown memory-enhancing properties in rodents and a good tolerability profile.
- GC10329 Mecamylamine hydrochloride nicotinic acetylcholine receptor antagonist
- GC10443 Meclofenoxate hydrochloride Drug for senile dementia and AD treatment
- GC13678 Methyllycaconitine citrate Methyllycaconitine citrate (MLA), a norditerpenoid alkaloid isolated from the seeds of Delphinium brownie.
- GC44209 Mivacurium (chloride) Mivacurium (chloride) is a benzylisoquinoline derivative and is a short-acting non-depolarizing neuromuscular blocking agent and skeletal muscle relaxant.
- GC34079 Monepantel (AAD1566) Monepantel (AAD1566) is organic anthelmintic, and acts as a positive allosteric modulator of a nematode-specific clade of nicotinic acetylcholine receptor (nAChR) subunits.
- GC63094 nAChR agonist 1 nAChR agonist 1 is a potent,?brain-permeable, and?orally?efficacious positive?allosteric?modulator?of α7?nicotinic?acetylcholine?receptor (α7 nAChR).
- GC33741 Nelonicline (ABT-126) Nelonicline (ABT-126) (ABT-126) is an orally active and selective α7 nicotinic receptor agonist with high affinity to α7 nAChRs in human brain (Ki=12.3 nM).
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GC13064
NS 1738
positive allosteric modulator of α7 nicotinic acetylcholine receptor
- GC50355 NS 6740 High affinity α7 nAChR partial agonist; anti-inflammatory
- GC45987 NS 9283 A positive allosteric modulator of α4β2 subunit-containing nAChRs
- GN10311 N-Methylcytisine
- GC11773 Pancuronium dibromide AChR antagonist
- GC38938 Pipecuronium bromide Pipecuronium bromide is a potent long-acting nondepolarizing steroidal neuromuscular blocking agent (NMBA), and a bisquaternary ammonium compound.
- GC12952 PNU 282987 α7 nAChR agonist
- GC11643 PNU-120596 α7 nAChR modulator,positive allosteric
- GC36942 PNU-282987 S enantiomer free base PNU-282987 S enantiomer free base is the S-enantiomer of PNU-282987 free base.
- GC36952 Pozanicline Pozanicline (ABT-089) selectively activate neuronal nicotinic acetylcholine receptor (nAChR) subtypes, is a novel cholinergic agent that is a partial agonist at α4β2* nAChRs (Ki=16 nM) and shows high selectivity for α6β2* and α4α5β2 nAChR subtypes, the binding affinity (Ki, rat) for Pozanicline to [3H] cytisine sites is 16.7 nM.
- GC38940 Pozanicline dihydrochloride Pozanicline dihydrochloride (ABT-089 dihydrochloride) is an orally bioavailable nicotinic acetylcholine receptor (nAChR) agonist with a Ki of 16.7 nM for binding to [3H]cytisine sites.
- GC37543 Rivanicline Rivanicline (RJR-2403; (E)-Metanicotine) is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM); > 1,000 fold selectivity than α7 receptors(Ki= 36000 nM).
- GC37544 Rivanicline hemioxalate Rivanicline hemioxalate (RJR-2403 hemioxalate; (E)-Metanicotine hemioxalate) is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM); > 1,000 fold selectivity than α7 receptors(Ki= 3.6 μM).
- GC12102 RJR-2403 oxalate
- GC31313 S16961 (S169611) S16961 (S169611) is a nicotinic receptor agonist.
- GC12959 SIB 1553A hydrochloride SIB 1553A hydrochloride is an orally bioavailable nicotinic acetylcholine receptors (nAChRs) agonist, with selectivity for β4 subunit-containing nAChRs.
- GC37662 Sofiniclin Sofiniclin (ABT 894), an agonist of nicotinic acetylcholine receptor (nAChR), is used as a potential non-stimulant research for attention-deficit/hyperactivity disorder (ADHD).
- GC50202 SSR 180711 hydrochloride Selective α7 nAChR partial agonist
- GC61317 Tebanicline dihydrochloride Tebanicline dihydrochloride (Ebanicline dihydrochloride) is a nAChR modulator with potent, orally effective analgesic activity.
- GC19351 Tebanicline hydrochloride Tebanicline hydrochloride (ABT594 hydrochloride) is a nAChR modulator with potent, orally effective analgesic activity.
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GC70059
Tribendimidine
Tribendimidine is a broad-spectrum anthelmintic drug with oral activity, which has particularly high activity against A. lumbricoides and N. americanus. Tribendimidine is also an L-type nicotine acetylcholine receptor (nAChR) agonist.
- GC12762 Varenicline α4β2 nAChRs antagonist
- GC16143 Varenicline Hydrochloride α4β2 nicotinic receptor agonist
- GC10948 Varenicline Tartrate Subtype-selective agonist of α4β2 nicotinic receptors,orally active
- GC11210 Vecuronium Bromide Nonpolarizing neuromuscular relaxant
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GC70130
VQW-765
VQW-765 (AQW-051) is a selective, orally active alpha-7 nicotinic acetylcholine receptor (α7-nAChR) agonist with a pKD value of 7.56 for recombinant human α7-nAChR. VQW-765 exhibits anxiolytic effects in vivo and can be used for research on anxiety disorders and acute anxiety.
- GC30807 ZSET1446 (ST-101) ZSET1446 (ST-101) is a novel cognitive enhancer that significantly improves learning deficits in various types of Alzheimer disease (AD) models.