Search Site
  • 0
    My Cart

    Click Here to Find How Many Items You Have Added:)

    image loader

    Adding item(s) to cart......

Home >> Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR

nAChR

nAChRs (nicotinic acetylcholine receptors) are neuron receptor proteins that signal for muscular contraction upon a chemical stimulus. They are cholinergic receptors that form ligand-gated ion channels in the plasma membranes of certain neurons and on the presynaptic and postsynaptic sides of theneuromuscular junction. Nicotinic acetylcholine receptors are the best-studied of the ionotropic receptors. Like the other type of acetylcholine receptor-the muscarinic acetylcholine receptor (mAChR)-the nAChR is triggered by the binding of the neurotransmitter acetylcholine (ACh). Just as muscarinic receptors are named such because they are also activated by muscarine, nicotinic receptors can be opened not only by acetylcholine but also by nicotine —hence the name "nicotinic".

Targets for  nAChR

Products for  nAChR

  1. Cat.No. Product Name Information
  2. GC63269 α-Conotoxin PIA TFA α-Conotoxin PIA TFA Chemical Structure
  3. GC63723 α-Conotoxin PnIA TFA α-Conotoxin PnIA TFA Chemical Structure
  4. GC70179 α7 Nicotinic receptor agonist-1

    Alpha-7 Nicotinic receptor agonist-1 (Preparation 5) is an alpha-7 nAChR agonist. It can be used for research on psychiatric disorders such as schizophrenia, mania or bipolar disorder, and anxiety disorders, as well as intellectual disabilities such as Alzheimer's disease, learning deficits, cognitive impairments, attention deficits, memory loss, Lewy body dementia and attention deficit hyperactivity disorder.

     α7 Nicotinic receptor agonist-1 Chemical Structure
  5. GC72246 αC-Conotoxin PrXA αC-Conotoxin PrXA is a paralytic peptide neurotoxin and a competitive nAChR antagonist, with IC50s of 1.8 nM (α1β1εδ, adult) and 3.0 nM (α1β1γδ, fetal), respectively. αC-Conotoxin PrXA Chemical Structure
  6. GC72625 (±)-Coniine hydrochloride (±)-Coniine hydrochloride (2-Propylpiperidine hydrochloride) is a potent nAChR agonist with an EC50 value of 0.3 mM. (±)-Coniine hydrochloride Chemical Structure
  7. GC14410 (±)-Epibatidine

    CMI 545

     nicotinic agonist (±)-Epibatidine Chemical Structure
  8. GC34959 (+)-Sparteine

    Pachycarpin, Pachycarpine

     (+)-Sparteine is a natural alkaloid acting as a ganglionic blocking agent. (+)-Sparteine Chemical Structure
  9. GC31084 (-)-(S)-B-973B (-)-(S)-B-973B Chemical Structure
  10. GC14157 (-)-Lobeline hydrochloride

    (-)-α-Lobeline, VUF 10751

     nicotinic receptor partial agonist (-)-Lobeline hydrochloride Chemical Structure
  11. GC63511 (Rac)-CP-601927 hydrochloride (Rac)-CP-601927 hydrochloride is the racemate of CP-601927. (Rac)-CP-601927 hydrochloride Chemical Structure
  12. GC64735 (S)-(-)-Levamisole (S)-(-)-Levamisole (Levamisole), an anthelmintic agent with immunomodulatory properties. (S)-(-)-Levamisole Chemical Structure
  13. GC60423 (S)-UFR2709 hydrochloride (S)-UFR2709 (hydrochloride) is a competitive nAChR antagonist?and displays higher affinity for α4β2 nAChRs than for α7 nAChRs. (S)-UFR2709 hydrochloride Chemical Structure
  14. GC69979 (S)-VQW-765

    (S)-AQW-051

    (S)-VQW-765 ((S)-AQW-051) is a partial agonist of the α7 nicotinic acetylcholine receptor (nAChR) with oral activity, selectivity and efficacy. It has potential applications in cognitive impairments associated with neurological diseases such as Alzheimer's disease or schizophrenia.

     (S)-VQW-765 Chemical Structure
  15. GC11757 3-Bromocytisine

    3-Br-cytisine

     α4β4, α4β2 and α7 nACh receptor agonist 3-Bromocytisine Chemical Structure
  16. GC18631 4BP-TQS An agonist of α7 subunit-containing nAChRs 4BP-TQS Chemical Structure
  17. GC60026 5-AAM-2-CP 5-AAM-2-CP is a major metabolite of Acetamiprid. 5-AAM-2-CP Chemical Structure
  18. GC60027 5-AMAM-2-CP 5-AMAM-2-CP is a major metabolite of Acetamiprid. 5-AMAM-2-CP Chemical Structure
  19. GC50088 A 85380 dihydrochloride High affinity and selective α4β2 nAChR agonist A 85380 dihydrochloride Chemical Structure
  20. GC15014 A-867744 A positive allosteric modulator of α7 nAChRs A-867744 Chemical Structure
  21. GC60549 ABT-418 hydrochloride ABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride Chemical Structure
  22. GC68602 Acetylcholine-d13 bromide

    ACh-d13 (bromide)

    Acetylcholine-d13 (bromide) is the deuterated form of Acetylcholine bromide.

     Acetylcholine-d13 bromide Chemical Structure
  23. GC13542 Adiphenine HCl

    NSC 129224, Spasmolytin, Trasentin

     Adiphenine HCl is a non-competitive inhibitor of nicotinic acetylcholine receptor (nAChR), with an IC50s of 1.9, 1.8, 3.7, and 6.3 μM for α1, α3β4, α4β2, and α4β4, respectively. Adiphenine HCl Chemical Structure
  24. GC30866 Anabasine ((S)-Anabasine) Anabasine ((S)-Anabasine) ((S)-Anabasine ((S)-Anabasine)) is an alkaloid that found as a minor component in tobacco (Nicotiana). Anabasine ((S)-Anabasine) Chemical Structure
  25. GC39254 Anatabine dicitrate Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier. Anatabine dicitrate Chemical Structure
  26. GC17695 Aniracetam

    Memodrin, Ro 13-5057, Sarpul

     Nootropic drug for senile dementia Aniracetam Chemical Structure
  27. GC45387 Aspergillimide

    Asperparaline A, VM 55598

     Aspergillimide ((rel)-Aspergillimide), an anthelmintic metabolite, is isolated from okara that has been fermented with Aspergillus japonicas JV-23. Aspergillimide Chemical Structure
  28. GC15667 Atracurium Besylate

    BW 33A, Tracrium, Wellcome 33A74

     Neuromuscular blocking agent Atracurium Besylate Chemical Structure
  29. GC14339 Benzethonium Chloride Potent inhibitor of nAChRs Benzethonium Chloride Chemical Structure
  30. GC35538 BNC375 BNC375 is a potent, selective, and orally available type I positive allosteric modulator of α7 nAChRs with an EC50 of 1.9 μM. BNC375 Chemical Structure
  31. GC73391 bPiDI bPiDI is a novel selective α6β2 nicotinic receptor antagonist. bPiDI inhibits nicotine-evoked striatal dopamine (DA) release through an interaction with α6β2-containing nAChRs. bPiDI Chemical Structure
  32. GC70230 Br-PBTC Br-PBTC is a potent, 2/4 subtype-selective positive allosteric modulator of nAChRs (nicotinic acetylcholine receptors) with α2β2，α2β4，α4β2，α4β4，(α4β2)2α4 and (α4β2)2β2 EC50 ranges from 0.1~0.6 μM. Br-PBTC Chemical Structure
  33. GC64064 Bradanicline

    TC-5619

     Bradanicline is a highly selective α7 nicotinic acetylcholine receptor (nAChR) agonist (humanα7 nAChR: EC50=17 nM; Ki= 1.4 nM). Bradanicline Chemical Structure
  34. GC16937 Carbamoylcholine chloride

    Carbachol

    Cholinergic receptor agonist

     Carbamoylcholine chloride Chemical Structure
  35. GC50126 CC4 High affinity and subtype-selective α6β2 and α4β2 nAChR partial agonist CC4 Chemical Structure
  36. GC12119 CCMI

    AVL-3288; UCI-4083

     Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors (nAChR) CCMI Chemical Structure
  37. GC16911 CGS 9343B

    KW-5617, Zaldaride Maleate

     CGS 9343B (CGS-9343B) is a potent, orally active and selective inhibitor of calmodulin. CGS 9343B Chemical Structure
  38. GC43261 Cholesteryl Myristate

    Cholesterol Myristate, Cholesteryl Tetradecanoate, Myristic Acid cholesteryl ester, NSC 226867

     Cholesteryl Myristate is a natural steroid present in traditional Chinese medicine. Cholesteryl Myristate binds to several ion channels such as the nicotinic acetylcholine receptor, GABAA receptor, and the inward-rectifier potassium ion channel. Cholesteryl Myristate Chemical Structure
  39. GC12226 Cisatracurium Besylate Neuromuscular-blocking drug Cisatracurium Besylate Chemical Structure
  40. GC50306 CMPI hydrochloride Potent positive allosteric modulator of α4β2 nAChRs; also inhibitor of (α4)2(β2)3, muscle-type and Torpedo nAChRs CMPI hydrochloride Chemical Structure
  41. GC63868 COG 133 TFA COG 133 TFA is a fragment of Apolipoprotein E (APOE) peptide. COG 133 TFA Chemical Structure
  42. GC63582 CP-601927 CP-601927 is a selective α4β2 nicotinic acetylcholine receptor (nAChR) partial agonist (Ki=1.2 nM; EC50=2.6 μM). CP-601927 Chemical Structure
  43. GC63583 CP-601932

    (1S,5R)-CP-601927

     CP-601932 ((1S,5R)-CP-601927) is a high-affinity partial agonist at α3β4 nAChR (Ki=21?nM; EC50=~ 3?μM). CP-601932 Chemical Structure
  44. GC31209 Cyclodrine hydrochloride Cyclodrine hydrochloride is a cholinergic (muscarinic, nicotinic) (mAChR and nAChR) receptor antagonist. Cyclodrine hydrochloride Chemical Structure
  45. GN10126 Cytisine

    Baptitoxine, Cytiton, Laburnin, Sophorine, Tsitafat

     Cytisine Chemical Structure
  46. GC16255 Decamethonium Bromide Nicotinic AChR partial agonist Decamethonium Bromide Chemical Structure
  47. GC12593 Desformylflustrabromine hydrochloride

    Deformylflustrabromine hydrochloride; dFBr hydrochloride

     Positive allosteric modulator of nicotinic α4β2 receptors Desformylflustrabromine hydrochloride Chemical Structure
  48. GC35858 Dianicline Dianicline is a α4β2 nicotinic acetylcholine receptor partial agonist, a class of drugs that includes varenicline and cytisine for smoking cessation. Dianicline Chemical Structure
  49. GC70918 Dicloromezotiaz Dicloromezotiaz is a potent insecticide acting on nicotinic acetylcholine receptors (nAChRs). Dicloromezotiaz Chemical Structure
  50. GC32185 Dinotefuran (MTI-446)

    1-Methyl-2-nitro-3-((tetrahydrofuran-3-yl)methyl)guanidine, MTI-446, Nidinotefuran

     Dinotefuran (MTI-446) is an insecticide of the neonicotinoid class, its mechanism of action involves disruption of the insect's nervous system by inhibiting nicotinic acetylcholine receptors. Dinotefuran (MTI-446) Chemical Structure
  51. GC70809 Epiboxidine hydrochloride Epiboxidine hydrochloride is a potent and selective neural nAChR agonist with Kis of 0.46 nM and 1.2 nM for rat and human α4β2 nAChRs, respectively. Epiboxidine hydrochloride Chemical Structure
  52. GC15941 EVP-6124

    EVP 6124;EVP6124

     A partial agonist of α7 subunit-containing nAChRs EVP-6124 Chemical Structure
  53. GC11091 EVP-6124 hydrochloride A partial agonist of α7 subunit-containing nAChRs EVP-6124 hydrochloride Chemical Structure
  54. GC39748 Facinicline hydrochloride

    RG3487 hydrochloride

     Facinicline hydrochloride (RG3487 hydrochloride) is an orally active nicotinic α7 receptor partial agonist, with a Ki of 6 nM for α7 human nAChR. Facinicline hydrochloride Chemical Structure
  55. GC60165 Ferulamide Ferulamide is a Ferulic acid derivative isolated from Portulaca oleracea L. Ferulamide Chemical Structure
  56. GC72117 FITC-α-Bungarotoxin FITC-α-Bungarotoxin is the FITC labelled α-Bungarotoxin . FITC-α-Bungarotoxin Chemical Structure
  57. GC66073 Flupyradifurone Flupyradifurone is a systemic nAChR agonist that interferes with signal transduction in the central nervous system of sucking pests. Flupyradifurone can be used as a butenolide insecticide. Flupyradifurone Chemical Structure
  58. GC64394 Flupyrimin Flupyrimin (FLP) is a novel insecticide with a trifluoroacetyl pharmacophore and an antagonist of insect nicotinic acetylcholine receptors (nAChRs). Flupyrimin Chemical Structure
  59. GC10913 GTS 21 dihydrochloride

    DMXB-A

     nAChRs agonist, novel GTS 21 dihydrochloride Chemical Structure
  60. GA22579 H-Ile-Trp-OH

    H-Ile-Trp-OH; IW-2143

     H-Ile-Trp-OH (H-Ile-Trp-OH) is an orally active α7 nAChR negative alteration modulator (NAM) with no apparent side effects. H-Ile-Trp-OH Chemical Structure
  61. GC15178 Hexamethonium Bromide Selective antagonist of neuronal-type nicotinic AChR Hexamethonium Bromide Chemical Structure
  62. GC43877 Hydroxy Bupropion

    BUPOH, OH-bupropion

     Buproprion is an inhibitor of the reuptake of dopamine and norepinephrine and is also an antagonist of neuronal acetylcholine nicotinic receptors. Hydroxy Bupropion Chemical Structure
  63. GC63928 Iptakalim hydrochloride Iptakalim hydrochloride, a lipophilic para-amino compound, is a novel ATP-sensitive potassium channel (KATP) opener, as well as an α4β2-containing nicotinic acetylcholine receptor (nAChR) antagonist. Iptakalim hydrochloride Chemical Structure
  64. GC63548 Ispronicline Ispronicline (TC-1734), an orally active, brain-selective α4β2 nicotine acetylcholine receptor (nAChR) partial agonist, has shown memory-enhancing properties in rodents and a good tolerability profile. Ispronicline Chemical Structure
  65. GC10329 Mecamylamine hydrochloride

    Inversine

     nicotinic acetylcholine receptor antagonist Mecamylamine hydrochloride Chemical Structure
  66. GC10443 Meclofenoxate hydrochloride

    Dimethylaminoethyl 4-chlorophenoxyacetate, Methocynal

     Drug for senile dementia and AD treatment Meclofenoxate hydrochloride Chemical Structure
  67. GC13678 Methyllycaconitine citrate

    MLA

     Methyllycaconitine citrate (MLA), a norditerpenoid alkaloid isolated from the seeds of Delphinium brownie. Methyllycaconitine citrate Chemical Structure
  68. GC44209 Mivacurium (chloride) Mivacurium (chloride) is a benzylisoquinoline derivative and is a short-acting non-depolarizing neuromuscular blocking agent and skeletal muscle relaxant. Mivacurium (chloride) Chemical Structure
  69. GC34079 Monepantel (AAD1566)

    AAD1566

     Monepantel (AAD1566) is organic anthelmintic, and acts as a positive allosteric modulator of a nematode-specific clade of nicotinic acetylcholine receptor (nAChR) subunits. Monepantel (AAD1566) Chemical Structure
  70. GC74716 N-Biotinyl p-aminophenyl arsenic acid N-Biotinyl p-aminophenyl arsenic acid is a bifunctional reagent that can bind to both streptavidin and dithiols. N-Biotinyl p-aminophenyl arsenic acid Chemical Structure
  71. GC63094 nAChR agonist 1 nAChR agonist 1 is a potent,?brain-permeable, and?orally?efficacious positive?allosteric?modulator?of α7?nicotinic?acetylcholine?receptor (α7 nAChR). nAChR agonist 1 Chemical Structure
  72. GC73333 nAChR-IN-1 nAChR-IN-1 is a tetrametlpiperidine heptanoate, a selective nicotinic acetylcholine receptor (nAChR) inhibitor that inhibits nAChRs lacking α5, α6, or β3 subunits. nAChR-IN-1 Chemical Structure
  73. GC33741 Nelonicline (ABT-126)

    ABT-126

     Nelonicline (ABT-126) (ABT-126) is an orally active and selective α7 nicotinic receptor agonist with high affinity to α7 nAChRs in human brain (Ki=12.3 nM). Nelonicline (ABT-126) Chemical Structure
  74. GC13064 NS 1738

    NSC 213859

    positive allosteric modulator of α7 nicotinic acetylcholine receptor

     NS 1738 Chemical Structure
  75. GC50355 NS 6740

    High affinity α7 nAChR partial agonist; anti-inflammatory

     NS 6740 Chemical Structure
  76. GC45987 NS 9283 NS 9283 is a positive allosteric modulator of the α4β2 subunit nicotinic acetylcholine receptor (nAChR). NS 9283 Chemical Structure
  77. GN10311 N－Methylcytisine

    Caulophylline, N-Me-cy

     N－Methylcytisine Chemical Structure
  78. GC11773 Pancuronium dibromide AChR antagonist Pancuronium dibromide Chemical Structure
  79. GC38938 Pipecuronium bromide Pipecuronium bromide is a potent long-acting nondepolarizing steroidal neuromuscular blocking agent (NMBA), and a bisquaternary ammonium compound. Pipecuronium bromide Chemical Structure
  80. GC12952 PNU 282987 PNU 282987 is a selective α7 nicotinic acetylcholine receptor (α7nAChR) agonist associated with an anti-inflammatory pathway as well as an antagonist of the 5-HT3 receptor, the EC50 of PNU 282987 for α7nAChR is 154nM (Ki α7nAChR=27nM, rat brain homogenates) while IC50 for 5-HT3 receptor is 4541nM (Ki 5-HT3R=1662nM, GR-65630). PNU 282987 Chemical Structure
  81. GC11643 PNU-120596

    NSC 216666

     PNU-120596 is a positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptor (α7nAChR) with an EC50 value of 216nM. PNU-120596 Chemical Structure
  82. GC36942 PNU-282987 S enantiomer free base PNU-282987 S enantiomer free base is the S-enantiomer of PNU-282987 free base. PNU-282987 S enantiomer free base Chemical Structure
  83. GC36952 Pozanicline

    ABT-089

     Pozanicline (ABT-089) selectively activate neuronal nicotinic acetylcholine receptor (nAChR) subtypes, is a novel cholinergic agent that is a partial agonist at α4β2* nAChRs (Ki=16 nM) and shows high selectivity for α6β2* and α4α5β2 nAChR subtypes, the binding affinity (Ki, rat) for Pozanicline to [3H] cytisine sites is 16.7 nM. Pozanicline Chemical Structure
  84. GC38940 Pozanicline dihydrochloride

    ABT-089 dihydrochloride

     Pozanicline dihydrochloride (ABT-089 dihydrochloride) is an orally bioavailable nicotinic acetylcholine receptor (nAChR) agonist with a Ki of 16.7 nM for binding to [3H]cytisine sites. Pozanicline dihydrochloride Chemical Structure
  85. GC37543 Rivanicline Rivanicline (RJR-2403; (E)-Metanicotine) is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM); > 1,000 fold selectivity than α7 receptors(Ki= 36000 nM). Rivanicline Chemical Structure
  86. GC37544 Rivanicline hemioxalate

    RJR-2403 hemioxalate; (E)-Metanicotine hemioxalate

     Rivanicline hemioxalate (RJR-2403 hemioxalate; (E)-Metanicotine hemioxalate) is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM); > 1,000 fold selectivity than α7 receptors(Ki= 3.6 μM). Rivanicline hemioxalate Chemical Structure
  87. GC12102 RJR-2403 oxalate RJR-2403 oxalate Chemical Structure
  88. GC31313 S16961 (S169611)

    S169611

     S16961 (S169611) is a nicotinic receptor agonist. S16961 (S169611) Chemical Structure
  89. GC12959 SIB 1553A hydrochloride SIB 1553A hydrochloride is an orally bioavailable nicotinic acetylcholine receptors (nAChRs) agonist, with selectivity for β4 subunit-containing nAChRs. SIB 1553A hydrochloride Chemical Structure
  90. GC37662 Sofiniclin

    ABT 894

     Sofiniclin (ABT 894), an agonist of nicotinic acetylcholine receptor (nAChR), is used as a potential non-stimulant research for attention-deficit/hyperactivity disorder (ADHD). Sofiniclin Chemical Structure
  91. GC50202 SSR 180711 hydrochloride Selective α7 nAChR partial agonist SSR 180711 hydrochloride Chemical Structure
  92. GC70459 Sulfoxaflor Sulfoxaflor is a sulfoximine insecticide and is an agonist of nAChR1 and nAChR2 subtypes. Sulfoxaflor Chemical Structure
  93. GC61317 Tebanicline dihydrochloride

    Ebanicline dihydrochloride; ABT-594 dihydrochloride

     Tebanicline dihydrochloride (Ebanicline dihydrochloride) is a nAChR modulator with potent, orally effective analgesic activity. Tebanicline dihydrochloride Chemical Structure
  94. GC19351 Tebanicline hydrochloride

    Ebanicline, Tebanicline

     Tebanicline hydrochloride (ABT594 hydrochloride) is a nAChR modulator with potent, orally effective analgesic activity. Tebanicline hydrochloride Chemical Structure
  95. GC70059 Tribendimidine

    Tribendimidine is a broad-spectrum anthelmintic drug with oral activity, which has particularly high activity against A. lumbricoides and N. americanus. Tribendimidine is also an L-type nicotine acetylcholine receptor (nAChR) agonist.

     Tribendimidine Chemical Structure
  96. GC12762 Varenicline α4β2 nAChRs antagonist Varenicline Chemical Structure
  97. GC16143 Varenicline Hydrochloride α4β2 nicotinic receptor agonist Varenicline Hydrochloride Chemical Structure
  98. GC10948 Varenicline Tartrate

    CP 526,55518

     Subtype-selective agonist of α4β2 nicotinic receptors,orally active Varenicline Tartrate Chemical Structure
  99. GC11210 Vecuronium Bromide

    NC 45

     Nonpolarizing neuromuscular relaxant Vecuronium Bromide Chemical Structure
  100. GC70130 VQW-765

    AQW-051

    VQW-765 (AQW-051) is a selective, orally active alpha-7 nicotinic acetylcholine receptor (α7-nAChR) agonist with a pKD value of 7.56 for recombinant human α7-nAChR. VQW-765 exhibits anxiolytic effects in vivo and can be used for research on anxiety disorders and acute anxiety.

     VQW-765 Chemical Structure
  101. GC30807 ZSET1446 (ST-101)

    ST-101

     ZSET1446 (ST-101) is a novel cognitive enhancer that significantly improves learning deficits in various types of Alzheimer disease (AD) models. ZSET1446 (ST-101) Chemical Structure

100 Item(s)

per page

Set Descending Direction