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SR 57227 hydrochloride

Catalog No.GC15630

A 5-HT3 receptor agonist

Products are for research use only. Not for human use. We do not sell to patients.

SR 57227 hydrochloride Chemical Structure

Cas No.: 77145-61-0

Size Price Stock Qty
10mg
$126.00
Ship Within 7 Days
50mg
$405.00
Ship Within 7 Days

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

SR 57227 hydrochloride is a potent, orally active and selective 5-HT3 receptor agonist, with ability to cross the blood brain barrier.

Chemical Properties

Cas No. 77145-61-0 SDF
Chemical Name 1-(6-chloropyridin-2-yl)piperidin-4-amine hydrochloride
Canonical SMILES ClC1=CC=CC(N2CCC(CC2)N)=N1.Cl
Formula C10H14ClN3.HCl M.Wt 248.15
Solubility Soluble to 50 mM in Water and to 100 mM in DMSO Storage Store at RT
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 4.0298 mL 20.1491 mL 40.2982 mL
5 mM 0.806 mL 4.0298 mL 8.0596 mL
10 mM 0.403 mL 2.0149 mL 4.0298 mL
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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Reviews

Review for SR 57227 hydrochloride

Average Rating: 5 ★★★★★ (Based on Reviews and 21 reference(s) in Google Scholar.)

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