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SZ1676

Catalog No.GC31228

SZ1676 is a derivative of SZ1677, which is a neuromuscular blocking agent.

Products are for research use only. Not for human use. We do not sell to patients.

SZ1676 Chemical Structure

Cas No.: 159325-23-2

Size Price Stock Qty
1mg
$276.00
In stock
5mg
$552.00
In stock
10mg
$937.00
In stock
20mg
$1,655.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Protocol

Animal experiment:

Dogs[2] Beagle dogs of about 10 kg body weight, anesthetized with isofurane are intubated and mechanically ventilated with O2, One fore-leg is fixed above the elbow and the wrist and the ulnar nerve is stimulated at the elbow, percutaneously,with supramaximal electrical impulses of 0.2 ms duration at 0.1 or 0.4 Hz.The force of flxion of the paw (P) is quantitated and contiuously recorded, At first the ED50, ED90 and ED95 of the 2 muscle relaxants (MR) are determined.Thirty min after maximal spontaneous recovery of P,the calculated 2×ED90 is injected and the time course ol the NM and circulatory effects are determined.

References:

[1]. Błazewicz A, et al. Application of high-performance liquid chromatography with amperometric and coulometric detection to the analysis of SZ1677, a new neuromuscular blocking agent, and its two derivatives. J Chromatogr A. 2008 Sep 12;1204(1):114-8.
[2]. Francis F. Foldes, et al. Comparison of the Neuromuscular Effects of SZ1676, SZ1677 and Vecuronium in Beagle Dogs. Muscle Relaxants pp 379-379.

Background

SZ1676 is a derivative of SZ1677, which is a neuromuscular blocking agent.

SZ1676 is the 3-acetoxy derivative[1]. The neuromuscular (NM) effects of SZ1676 and SZ1677 are compared in beagle dogs. SZ1677 (ED90=19.2±2.6 μg/kg) is 1.86 times more potent than SZ1676 (ED90=35.8±2.5 μg/kg)[2].

[1]. B?azewicz A, et al. Application of high-performance liquid chromatography with amperometric and coulometric detection to the analysis of SZ1677, a new neuromuscular blocking agent, and its two derivatives. J Chromatogr A. 2008 Sep 12;1204(1):114-8. [2]. Francis F. Foldes, et al. Comparison of the Neuromuscular Effects of SZ1676, SZ1677 and Vecuronium in Beagle Dogs. Muscle Relaxants pp 379-379.

Chemical Properties

Cas No. 159325-23-2 SDF
Canonical SMILES C[C@@]12[C@](C[C@H]([N+]3(CCCC3)CC=C)[C@@H]2OC(C)=O)([H])[C@@]4([H])[C@]([C@@]5([C@@](C[C@H](OC(C)=O)[C@@H](N6CCC7(OCCO7)CC6)C5)([H])CC4)C)([H])CC1.[Br-]
Formula C37H59BrN2O6 M.Wt 707.78
Solubility Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.4129 mL 7.0643 mL 14.1287 mL
5 mM 0.2826 mL 1.4129 mL 2.8257 mL
10 mM 0.1413 mL 0.7064 mL 1.4129 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Reviews

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Average Rating: 5 ★★★★★ (Based on Reviews and 5 reference(s) in Google Scholar.)

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