(±)-Thalidomide-d4 (Synonyms: N-Phthaloylglutamimide-d4) |
| Catalog No.GC46008 |
An internal standard for the quantification of (±)-thalidomide
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1219177-18-0
Sample solution is provided at 25 µL, 10mM.
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(±)-Thalidomide-d4 is intended for use as an internal standard for the quantification of (±)-thalidomide by GC- or LC-MS. (±)-Thalidomide is an immunomodulatory and antiproliferative compound that interacts directly with the protein CRBN (IC50 = 8.5 nM), a ubiquitously-expressed E3 ligase, and CRBN-DDB1 complexes.1,2
|1. Ito, T., Ando, H., Suzuki, T., et al. Identification of a primary target of thalidomide teratogenicity. Science 327(5971), 1345-1350 (2010).|2. Lopez-Girona, A., Mendy, D., Miller, K., et al. Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide. Leukemia 26(11), 2326-2335 (2012).
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