Endothelin Receptor
Endothelin receptors are members of rhodopsin-like g-protein coupled receptor (GPCRA) with 4 types (ETA, ETB1, ETB2 and ETC), which mediate various physiological processes including vasoconstriction, vasodilation, and neurotransmission etc.
Products for Endothelin Receptor
- Cat.No. Product Name Information
- GC50247 A 127722 Highly potent, selective ETA antagonist; orally bioavailable
- GC60544 A-192621 A-192621 is a potent, nonpeptide, orally active and selective endothelin B (ETB) receptor antagonist with an IC50 of 4.5 nM and a Ki of 8.8 nM.
- GC13236 ACT-132577 ACT-132577 (ACT-132577) is the major and pharmacologically active metabolite of Macitentan.
- GC17184 Ambrisentan ETA-receptor antagonist
- GC32548 Aminaftone (Aminaftone) Aminaftone (Aminaftone), a derivative of 4-aminobenzoic acid, downregulates endothelin-1 (ET-1) production in vitro by interfering with the transcription of the pre-pro-ET-1 gene.
- GC68320 Aprocitentan D4
- GC35424 Atrasentan Atrasentan (ABT-627) is an endothelin receptor antagonist with IC50 of 0.0551 nM for ETA.
- GC11783 Atrasentan hydrochloride
- GC11314 Atrial natriuretic factor (1-28) (rat) Atrial natriuretic factor (1-28) (rat) is a major circulating form of ANP in rats, potently inhibits Angiotensin II (Ang II)-stimulated endothelin-1 secretion in a concentration-dependent manner.
- GC34023 Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Atrial Natriuretic Peptide (ANP) (1-28), human, porcine (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine) is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch.
- GC34025 Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine acetate) is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch.
- GC35426 Atrial Natriuretic Peptide (ANP) (1-28), rat TFA Atrial Natriuretic Peptide (ANP) (1-28), rat (TFA) is a major circulating form of ANP in rats, potently inhibits Angiotensin II (Ang II)-stimulated endothelin-1 secretion in a concentration-dependent manner.
- GC11405 Avosentan
- GC16269 Bosentan Endothelin receptor antagonist
- GC11465 Bosentan Hydrate endothelin receptor antagonist
- GC15887 BQ-123 Selective ETA receptor antagonist
- GC60094 BQ-3020 TFA BQ-3020 (TFA) is a selective agonist of ETB receptor, inhibits [125I]ET-1 binding to ETB receptor with an IC50 of 0.2 nM in cerebellum, and causes vasoconstriction.
- GC35546 BQ-788 BQ-788 is a potent, selective ETB receptor antagonist with IC50 of 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells, poorly inhibiting the binding to ETA receptors in human neuroblastoma cell line SK-N-MC cells with IC50 of 1300 nM.
- GC15916 BQ-788 sodium salt ET B-receptor antagonist,potent and selective
- GC68435 Clazosentan
- GC35811 Darusentan Darusentan (Lu-135252) is a selective endothelin receptor A (ET-A) receptor antagonist, which binds with a Ki of 1.4 nM to the ET-A receptor and a Ki of 184 nM to ET-B receptor, respectively with a 100-fold selectivity for ETA rather than ETB receptors.
- GC64457 Endothelin 1 (swine, human) (TFA) Endothelin 1 (swine, human) (TFA) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor.
- GC30485 Endothelin 1 swine, human Endothelin 1 swine, human is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor.
- GC13924 Endothelin 3 (human, rat) Endothelin 3 (human, rat) is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.
- GC30577 Endothelin Mordulator 1 Endothelin Mordulator 1 is a endothelin receptor modulator, used for the research of endothelin-mediated disorders.
- GC30937 IRL-1620 IRL-1620 is a potent and selective endothelin receptor type B (ETB) agonist with a Ki of 16 pM.
- GC38641 IRL-1620 TFA IRL-1620 (TFA) is a potent and selective endothelin receptor type B (ETB) agonist with a Ki of 16 pM.
- GC15246 IRL-2500 endothelin receptor antagonist
- GC18501 Kendomycin Kendomycin is a macrolide from Streptomyces which displays potent cytotoxicity against several carcinoma cell lines (GI50 < 100 nM).
- GC17785 Macitentan Endothelin (ET)(A) and ET(B) receptor antagonist
- GC36525 Macitentan n-butyl analogue Macitentan n-butyl analogue is a n-butyl analogue of Macitentan.
- GC45723 Macitentan-d4 An internal standard for the quantification of macitentan
- GC60266 Nebentan free base Nebentan free base (YM598 free base) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan.
- GC61118 Nebentan potassium Nebentan potassium (YM598) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan.
- GC34031 PD-159020 PD-159020 is a non-selective ETA/ETB antagonist, with IC50s of 30 and 50 nM for hETA and hETB, respectively.
- GC32528 Ro 46-2005 Ro 46-2005 is a novel synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA receptor) with IC50 of 220 nM.
- GC63837 Ro 46-8443 Ro 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist.
- GC13175 Sarafotoxin S6a Endothelin receptor agonist
- GC14678 Sarafotoxin S6b non-selective endothelin receptor agonist
- GC17769 Sitaxentan sodium Sitaxentan sodium (IPI 1040 sodium; TBC11251 sodium) is an orally active, highly selective antagonist of endothelin A receptors.
- GC37644 Sitaxsentan Sitaxsentan (IPI 1040; TBC-11251) is a selective endothelin A (ETA) receptor antagonist.
- GC32479 Sparsentan (RE-021) Sparsentan (RE-021) (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Kis of 0.8 and 9.3 nM, respectively.
- GC12231 Sulfisoxazole selective ETA endothelin receptor antagonist
- GC30942 Tezosentan (RO 610612) Tezosentan (RO 610612) (RO 610612) is an endothelin (ET) receptor antagonist, with pA2s of 9.5, 7.7 for ETA and ETB receptors, respectively.
- GC32556 ZD-1611 ZD-1611 is a potent, orally active, selective ETA receptor antagonist, used for the research of ischemic stroke.
- GC16862 Zibotentan (ZD4054) Zibotentan (ZD4054) (ZD4054) is a potent, selective and orally active endothelin A (ETA) receptor antagonist with a Ki of 13 nM.