20-hydroxy Leukotriene B4 (Synonyms: 20hydroxy LTB4) |
| Catalog No.GC41421 |
20-hydroxy LTB4 is a metabolite of LTB4 in human neutrophils.
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Cas No.: 79516-82-8
Sample solution is provided at 25 µL, 10mM.
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20-hydroxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. 20-hydroxy LTB4 is not only much less active (~5%) compared to LTB4 in causing degranulation of PMNL, but actually inhibits LTB4-induced degranulation of human neutrophils (Ki = 13.3 nM). However, 20-hydroxy LTB4 is as active as LTB4 in contracting parenchymal strips from guinea pig lung. 20-hydroxy LTB4 retains considerable ligand binding affinity at the BLT2 receptor, but does not appear to function as an agonist.
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