ARCA (Synonyms: Anti Reverse Cap Analog, 3´-O-Me-m7G(5')ppp(5')G) |
| Catalog No.GC16608 |
Anti-Reverse Cap Analog (ARCA) is a modified cap analog in which the 3' OH group (closer to m7G) is replaced with –OCH3.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Anti-Reverse Cap Analog (ARCA) is a modified cap analog in which the 3' OH group (closer to m7G) is replaced with –OCH3. Because of this substitution, the RNA polymerase can only initiate transcription with the remaining hydroxyl group and forcing ARCA incorporation in the forward orientation. Thus, ARCA ensures incorporation in the forward orientation only. As a result, 100% of the transcripts synthesized with ARCA at the 5' end are translatable leading to a strong stimulatory effect on translation.
References:
[1].Janowski M, et al. The legacy of mRNA engineering: A lineup of pioneers for the Nobel Prize. Mol. Ther. Nucleic Acids. 2022 Sep 13; 29: 272-284.
Average Rating: 5 (Based on Reviews and 31 reference(s) in Google Scholar.)
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